Now showing items 1-7 of 7

    • Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death 

      Parra, Valentina; Moraga, Francisco; Kuzmicic, Jovan; López Crisosto, Camila; Troncoso, Rodrigo; Torrealba, Natalia; Criollo Céspedes, Alfredo; Díaz Elizondo, Jessica; Rothermel, Beverly A.; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2013)
      Ceramides are important intermediates in the biosynthesis and degradation of sphingolipids that regulatenumerous cellular processes, including cell cycle progression, cell growth, differentiation and death. In ...
    • Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury 

      Zepeda Iriarte, Ramiro; Kuzmicic, Jovan; Parra Ortiz, Valentina; Troncoso Cotal, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Sánchez, Gina; Lavandero González, Sergio (Lippincott Williams and Wilkins, 2014)
      Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
    • Impaired cardiac autophagy in patients developing postoperative atrial fibrillation 

      García Nannig, Lorena; Verdejo, Hugo; Kuzmicic, Jovan; Zalaquett Sepúlveda, Ricardo; Gonzalez, Sergio; Lavandero González, Sergio; Corbalán, Ramón (Mosby Inc., 2012)
      Objectives: Postoperative atrial fibrillation (POAF) is a common complication after on-pump heart surgery. Several histologic abnormalities, such as interstitial fibrosis and vacuolization, have been described in atrial ...
    • Mitochondrial dynamics: A potential new therapeutic target for heart failure Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca 

      Kuzmicic, Jovan; Del Campo, Andrea; López Crisosto, Camila; Morales, Pablo E.; Pennanen, Christian; Bravo Sagua, Roberto; Hechenleitner, Jonathan; Zepeda, Ramiro; Castro, Pablo F.; Verdejo, Hugo; Parra, Valentina; Chiong Lay, Mario; Lavandero González, Sergio (2011)
      Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. ...
    • Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway 

      Pennanen, Christian; Parra, Valentina; López Crisosto, Camila; Morales, Pablo E.; del Campo, Andrea; Gutierrez, Tomás; Rivera Mejías, Pablo; Kuzmicic, Jovan; Chiong Lay, Mario; Zorzano, Antonio; Rothermel, Beverly A.; Lavandero González, Sergio (Company of Biologists Ltd, 2014)
      Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism. Mitochondria are crucial organelles for the production of ATP, and their morphology and function are regulated by the dynamic processes ...
    • The complex interplay between mitochondrial dynamics and cardiac metabolism 

      Parra Ortíz, María Valentina; Verdejo, Hugo; Campo Sfeir, Andrea Estefanía del; Pennanen Saavedra, Christian; Kuzmicic, Jovan; Iglewski, Myriam; Hill, Joseph A.; Rothermel, B. A.; Lavandero González, Sergio (SPRINGER/PLENUM PUBLISHERS, 2011-02)
      Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of ...
    • Vasodilator and hypotensive effects of pure compounds and hydroalcoholic extract of Xenophyllum poposum (Phil) V.A Funk (Compositae) on rats 

      Cifuentes, Fredi; Palacios, Javier; Kuzmicic, Jovan; Carvajal, Lorena; Muñoz, Fernanda; Quispe, Cristina; Nwokocha, Chukwuemeka R.; Morales, Glauco; Norambuena Soto, Ignacio; Chiong Lay, Mario; Paredes, Adrián (Elsevier GmbH, 2018)
      © 2018 Background: Xenophyllum poposum is an endemic species of the Andes Cordillera, popularly known as Popusa. Popusa is widely used by mountain communities as a folk medicine to treat altitude sickness and hypertension. ...