Now showing items 1-19 of 19

    • ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT2a and 5-HT2c receptor agonist 

      Acuña Castillo, Claudio; Scorza, Cecilia; Reyes Parada, Miguel; Cassels Niven, Bruce; Huidobro Toro, Juan Pablo (Elsevier Science Inc., 2000-06-06)
      To assess the pharmacodynamic profile of ALEPH-2, a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties, Xenopus laevis oocytes were microinjected with either of the rat cRNA for the ...
    • Chitosan-based nanoparticles for Intracellular delivery of ISAV fusion protein cDNA into melanoma cells: a path to develop oncolytic anticancer therapies 

      Robles Planells, Claudia; Sánchez-Guerrero, Giselle; Barrera Ávalos, Carlos; Matiacevich, Silvia; Rojo, Leonel E.; Pavéz, Jorge; Salas Huenuleo, Edison; Kogan, Marcelo J.; Escobar Álvarez, Alejandro; Milla, Luis A.; Fernández, Ricardo; Imarai, Mónica; Spencer, Eugenio; Huidobro Toro, Juan Pablo; Acuña Castillo, Claudio (Hindawi, 2020)
      Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation ...
    • Dead tumor cells expressing infectious salmon anemia virus fusogenic protein favor antigen cross-priming in vitro 

      Morales, Jonathan; Barrera Avalos, Carlos; Castro, Carlos; Castillo, Stephanie; Barrientos, Claudio; Robles Planells, Claudia; López, Ximena; Torres, Ernesto; Montoya, Margarita; Cortez San Martin, Marcelo; Riquelme, Denise; Escobar Álvarez, Alejandro; Fernández, Ricardo; Imarai, Mónica; Sauma Mahaluf, Daniela; Rojo, Leonel E.; Leiva Salcedo, Elias; Acuña Castillo, Claudio (Frontiers media SA, 2017)
      Antigen cross-presentation is a crucial step in the assembly of an antitumor immune response leading to activation of naive CD8 T cells. This process has been extensively used in clinical trials, in which dendritic cells ...
    • Defect in ERK2 and p54JNK activation in aging mouse splenocytes 

      Li, Min; Torres, Claudio; Acuña Castillo, Claudio; Walter, Robin Ann; Gardner, Elizabeth M.; Murasko, Donna M.; Sierra, Felipe (2002)
      We have previously reported on a defect in both extracellular signal-regulated protein kinase (ERK) and c-jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) activation in splenocytes obtained from old rats. ...
    • Di erences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT2A and 5-HT2C receptors 

      Acuña Castillo, Claudio; Villalobos, Claudio; Moya, Pablo R.; Sáez, Patricio; Cassels Niven, Bruce; Huidobro Toro, Juan Pablo (Nature Publishing Group, 2002-04-04)
      1 The pharmacological pro®le of a series of (+)-2,5-dimethoxy-4-(X)-phenylisopropylamines (X=I, Br, NO2, CH3, or H) and corresponding phenylethylamines, was determined in Xenopus laevis oocytes injected with cRNA coding ...
    • Diminished Acute Phase Response and Increased Hepatic Inflammation of Aged Rats in Response to Intraperitoneal Injection of Lipopolysaccharide 

      Gómez, Christian; Acuña Castillo, Claudio; Pérez Núñez, Claudio; Leiva Salcedo, Elías; Riquelme, Denise; Ordenes, Gamaliel; Oshima, Kiyoko; Aravena, Mauricio; Pérez, Viviana I.; Nishimura, Sumiyo; Sabaj Diez, Valeria; Walter, Robin Ann; Sierra, Felipe (GERONTOLOGICAL SOC AMER, 2008-12)
      Aging is associated with a deterioration of the acute phase response to inflammatory challenges. However, the nature of these defects remains poorly defined. We analyzed the hepatic inflammatory response after intraperitoneal ...
    • Lipopolysaccharide inhibits the channel activity of the P2X7 receptor 

      Leiva Salcedo, Elías; Coddou, Claudio; Rodríguez, Felipe; Penna, Antonello; López, Ximena; Neira, Tanya; Fernández, Ricardo; Imarai, Mónica; Rios, Miguel; Escobar, Jorge; Montoya, Margarita; Huidobro Toro, Juan; Escobar, Alejandro; Acuña Castillo, Claudio (2011)
      The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) ...
    • Metabolic syndrome and antipsychotics: The role of mitochondrial fission/fusion imbalance 

      Campo, Andrea del; Bustos, Catalina; Mascayano, Carolina; Acuña Castillo, Claudio; Troncoso, Rodrigo; Rojo, Leonel E. (Frontiers Media SA, 2018)
      Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There ...
    • Neisseria gonorrhoeae Induces a Tolerogenic Phenotype in Macrophages to Modulate Host Immunity 

      Escobar Álvarez, Alejandro; Candia, Enzo; Reyes Cerpa, Sebastián; Villegas Valdés, Bélgica; Neira, Tanya; López Nitsche, Mercedes; Maisey, Kevin; Tempio, Fabián; Ríos, Miguel; Acuña Castillo, Claudio; Imarai, Mónica (Hindawi, 2013)
      Neisseria gonorrhoeae is the etiological agent of gonorrhoea, which is a sexually transmitted disease widespread throughout the world. N. gonorrhoeae does not improve immune response in patients with reinfection, suggesting ...
    • Neisseria gonorrhoeae Modulates Immunity by Polarizing Human Macrophages to a M2 Profile 

      Ortiz, María Carolina; Lefimil Puente, Claudia; Rodas, Paula I.; Vernal Astudillo, Rolando; López, Mercedes; Acuña Castillo, Claudio; Imarai, Mónica; Escobar, Alejandro (Public Library Science, 2015)
      Current data suggest that Neisseria gonorrhoeae is able to suppress the protective immune response at different levels, such as B and T lymphocytes and antigen-presenting cells. The present report is focused on gonococcus ...
    • PGC-1α-dependent mitochondrial adaptation is necessary to sustain IL-2-induced activities in human NK cells 

      Miranda, Dante; Jara, Claudia; Ibañez, Jorge; Ahumada, Viviana; Acuña Castillo, Claudio; Martin, Adrian; Córdova, Alexandra; Montoya, Margarita (Hindawi Publishing Corporation, 2016)
      Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in antitumor defense reactions. NK cell effector functions are critically dependent on cytokines and metabolic activity. ...
    • Polymyxin B increases the depletion of T regulatory cell induced by purinergic agonist 

      Cappelli, Claudio; López Cortés, Ximena; Labra, Yohana; Montoya, Margarita; Fernández, Ricardo; Imarai, Mónica; Rojas, Juan Luis; Miranda, Dante; Escobar Alvarez, Alejandro; Acuña Castillo, Claudio (Elsevier, 2012)
      Regulatory T cells (Treg) are important in the development of immune tolerance under normal physiological conditions. However, in pathological situations such as cancer, Treg increases have been correlated with bad ...
    • Serum from aged F344 rats conditions the activation of young macrophages 

      Gómez, Christian; Acuña Castillo, Claudio; Nishimura, Sumiyo; Pérez, Viviana; Escobar, Alejandro; Salazar Onfray, Flavio; Sabaj Diez, Valeria; Torres, Claudio; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2006-03)
      There is considerable controversy about the molecular mechanisms responsible for the variations in innate immunity associated with age. While in vivo, aged animals and humans react to an inflammatory signal with ail excessive ...
    • T-kininogen can either induce or inhibit proliferation in Balb/c 3T3 fibroblasts, depending on the route of administration 

      Aravena, Mauricio; Pérez, C.; Pérez, V.; Acuña Castillo, Claudio; Gómez, Christian; Leiva Salcedo, Elías; Nishimura, Sumiyo; Sabaj, B.; Walter, Robin Ann (ELSEVIER SCI IRELAND LTD, 2005-03)
      T-kininogen (T-KG) is a precursor of T-kinin, the most abundant kinin in rat serum, and also acts as a strong and specific cysteine proteinase inhibitor. Its expression is strongly induced during aging in rats, and expression ...
    • T-kininogen induces endothelial cell proliferation 

      Pérez, Viviana; Leiva Salcedo, Elías; Acuña Castillo, Claudio; Aravena, Mauricio; Gómez, Christian; Sabaj Diez, Valeria; Colombo, Alicia; Nishimura, Sumiyo; Pérez Núñez, Claudio; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2006-03)
      Basal proliferation of endothelial cells increases with age, and this might play a role in the etiology of age-related vascular diseases, as well as angiogenesis. Serum kininogen levels increase during aging in rats and ...
    • T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells 

      Leiva-Salcedo, Elias; Perez, Viviana; Acuña Castillo, Claudio; Walter, Robin Ann; Sierra, Felipe (Society of Biology of Chile, 2002)
      Serum levels of T-kininogen increase dramatically as rats approach the end of their lifespan. Stable expression of the protein in Balb/c 3T3 fibroblasts leads to a dramatic inhibition of cell proliferation, as well as ...
    • T-kininogen, a cystatin-like molecule, inhibits ERK-dependent lymphocyte proliferation 

      Acuña Castillo, Claudio; Aravena, Mauricio; Leiva Salcedo, Elías; Pérez, Viviana; Gómez, Christian; Sabaj Diez, Valeria; Nishimura, Sumiyo; Pérez Núñez, Claudio; Colombo, Alicia; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2005-12)
      Plasma levels of kininogens increase with age in both rats and humans. Kininogens are inhibitors of cysteine proteinases, and filarial cysteine proteinase inhibitors (cystatins) reduce the proliferation of T cells. We ...
    • T-kininogen: A biomarker of aging in fisher 344 rats with possible implications for the immune response 

      Acuña Castillo, Claudio; Leiva-Salcedo, Elias; Gómez, Christian R.; Pérez, Viviana; Li, Min; Torres, Claudio; Walter, Robin Ann; Murasko, Donna M.; Sierra, Felipe (Gerontological Society of America, 2006)
      T-kininogen (T-KG) is a reliable biomarker of aging in male Sprague-Dawley rats. Here we confirm, in a longitudinal study, a similar behavior in Fisher 344 rats of both sexes. In males, the increase in serum levels of T-KG ...
    • Tolerogenic Dendritic Cells Derived from Donors with Natural Rubber Latex Allergy Modulate Allergen-Specific T-Cell Responses and IgE Production 

      Escobar Álvarez, Alejandro; Aguirre, Adam; Guzmán Meléndez, María Antonieta; González González, Rodrigo; Catalán Martina, Diego; Acuña Castillo, Claudio; Larrondo Lillo, Milton; López Nitsche, Mercedes; Pesce Reyes, Bárbara; Rolland, Jennifer; O’Hehir, Robyn; Aguillón Gutiérrez, Juan Carlos (2014)
      Natural rubber latex (NRL; Hevea brasiliensis) allergy is an IgE-mediated reaction to latex proteins. When latex glove exposure is the main sensitizing agent, Hev b 5 is one of the major allergens. Dendritic cells (DC), ...