Browsing by Author "87ac554b-bb98-44e1-80a5-fc761af0ee64"

Now showing items 1-4 of 4

    • ADP-dependent 6-phosphofructokinase from pyrococcus horikoshii OT3. Structure determination and biochemical ... 
      Currie, Mark A.; Merino, Felipe; Skarina, Tatiana; Wong, Andrew H.Y.; Singer, Alexander; Brown, Greg; Savchenko, Alexei; Caniuguir, Andrés; Guixé Leguía, Victoria Cristina; Yakunin, Alexander F.; Jia, Zongchao (2009)
      Some hyperthermophilic archaea use a modified glycolytic pathway that employs an ADP-dependent glucokinase (ADP-GK) and an ADP-dependent phosphofructokinase (ADP-PFK) or, in the case of Methanococcus jannaschii, a bifunctional ...
    • Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity ... 
      Castro Fernández, Víctor; Herrera Morande, Alejandra; Zamorano Sarria, Ricardo; Merino, Felipe; González Órdenes, Felipe; Padilla Salinas, Felipe; Pereira, Humberto M.; Brandao Neto, José; Garratt, Richard C.; Guixé Leguía, Victoria Cristina (American Society for Biochemistry and Molecular Biology, 2017)
      One central goal in molecular evolution is to pinpoint the mechanisms and evolutionary forces that cause an enzyme to change its substrate specificity; however, these processes remain largely unexplored. Using the glycolytic ...
    • Specificity evolution of the ADP-dependent sugar kinase family - in silico studies of the glucokinase/pho ... 
      Merino, Felipe; Guixé Leguía, Victoria Cristina (2008)
      In several archaea of the Euryarchaeota, the glycolytic flux proceeds through a modified version of the Embden-Meyerhof pathway, where the phosphofructokinase and glucokinase enzymes use ADP as the phosphoryl donor. These ...
    • Valoración de Salfacorp S.A. 
      Merino, Felipe; Ramírez Fuentes, Marco A. (2018-05)
      Este trabajo tiene como objetivo la valoración de la empresa Salfacorp S.A. al 30 de Septiembre de 2017, utilizando el método del Flujo de Caja Libre Descontado y valorización por múltiplos. Salfacorp es una de las ...