Browsing by Author "8c080b8e-ba13-4b92-83db-351c3dc4111b"

Now showing items 1-10 of 10

    • Acquisition, maintenance and relapse-like alcohol drinking: Lessons from the uchb rat line 
      Israel Jacard, Yedy; Karahanian, Eduardo; Ezquer, Fernando; Morales, Paola; Ezquer, Marcelo; Rivera Meza, Mario; Herrera-Marschitz Muller, Mario; Quintanilla González, María Elena (Frontiers Media S.A., 2017)
      © 2017 Israel, Karahanian, Ezquer, Morales, Ezquer, Rivera-Meza, Herrera-Marschitz and Quintanilla. This review article addresses the biological factors that influence: (i) the acquisition of alcohol intake; (ii) the ...
    • Cloning and molecular analysis of a cDNA and the Cs-mnpl gene encoding a manganese peroxidase isoenzyme ... 
      Montané Lobos, Sergio Luis Andrés; Larrondo, Luis F.; Salas, Loreto; Karahanian, Eduardo; Vicuña, Rafael (1998)
      A cDNA (MnP13-1) and the Cs-mnp1 gene encoding for an isoenzyme of manganese peroxidase (MnP) from C. subvermispora were isolated separately and sequenced. The cDNA, identified in a library constructed in the vector Lambda ...
    • Ethanol as a Prodrug: Brain Metabolism of Ethanol Mediates its Reinforcing Effects 
      Karahanian, Eduardo; Quintanilla González, María Elena; Tampier de Jong, Lutske; Rivera Meza, Mario; Bustamante, Diego; González Lira, Víctor; Morales, Paola; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (2011)
      Background: While the molecular entity responsible for the rewarding effects of virtually all drugs of abuse is known, that for ethanol remains uncertain. Some lines of evidence suggest that the rewarding effects of alcohol ...
    • Fenofibrate - A lipid-lowering drug - Reduces voluntary alcohol drinking in rats 
      Karahanian, Eduardo; Quintanilla González, María Elena; Fernandez, Katia; Israel Jacard, Yedy (Elsevier Inc., 2014)
      © 2014 Elsevier Inc.The administration of disulfiram raises blood acetaldehyde levels when ethanol is ingested, leading to an aversion to alcohol. This study was aimed at assessing the effect of fenofibrate on voluntary ...
    • Fenofibrate administration reduces alcohol and Saccharin Intake in rats: possible effects at peripheral and ... 
      Rivera Meza, Mario; Muñoz, Daniel; Jerez, Erik; Quintanilla González, María Elena; Salinas Luypaert, Catalina; Fernandez, Katia; Karahanian, Eduardo (Frontiers media SA, 2017)
      We have previously shown that the administration of fenofibrate to high-drinker UChB rats markedly reduces voluntary ethanol intake. Fenofibrate is a peroxisome proliferator-activated receptor alpha (PPAR a) agonist, which ...
    • Fenofibrato -un agonista de PPARα- incrementa los niveles de la alcohol deshidrogenasa hepática: implicaciones ... 
      Muñoz, Daniel; Rivera Meza, Mario; Flores Bastías, Osvaldo; Quintanilla González, María Elena; Karahanian, Eduardo (Socidrogalcohol. Sociedad Científica Española de Estudio sobre el Alcohol, el Alcoholismo y las otras Toxocomanías, 2020)
      Tras consumir etanol, el disulfiram incrementa los niveles de acetaldehído en sangre y genera una reacción aversiva que desalienta el consumo de alcohol. Dados los importantes efectos secundarios del disulfiram, es ...
    • Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational ... 
      Israel Jacard, Yedy; Quintanilla González, María Elena; Ezquer, Fernando; Morales, Paola; Rivera Meza, Mario; Karahanian, Eduardo; Ezquer, Marcelo; Herrera Marschitz, Mario (Nature Publishing Group, 2019)
      Studies reviewed show that lentiviral gene therapy directed either at inhibiting the synthesis of brain acetaldehyde generated from ethanol or at degrading brain acetaldehyde fully prevent ethanol intake by rats bred for ...
    • Gene specific modifications unravel ethanol and acetaldehyde actions 
      Israel Jacard, Yedy; Rivera Meza, Mario; Karahanian, Eduardo; Quintanilla González, María Elena; Tampier de Jong, Lutske; Morales Retamales, Paola; Herrera-Marschitz Muller, Mario (FRONTIERS RESEARCH FOUNDATION, 2013-07-08)
      Ethanol is metabolized into acetaldehyde mainly by the action of alcohol dehydrogenase in the liver, while mainly by the action of catalase in the brain. Aldehyde dehydrogenase-2 metabolizes acetaldehyde into acetate in ...
    • Gene therapy reduces ethanol intake in an animal model of alcohol dependence 
      Ocaranza, Paula; Quintanilla González, María Elena; Tampier de Jong, Lutske; Karahanian, Eduardo; Sapag, Amalia; Israel Jacard, Yedy (2008)
      Background: Some gene polymorphisms strongly protect against the development of alcoholism. A large proportion of East Asians carry a protective inactivating mutation in aldehyde dehydrogenase (ALDH2*2). These subjects ...
    • Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases ... 
      Quintanilla González, María Elena; Rivera Meza, Mario; Berríos Cárcamo, Pablo; Bustamante, Diego; Buscaglia, Marianne; Morales, Paola; Karahanian, Eduardo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Elsevier Inc., 2014)
      © 2014 Elsevier Inc.Salsolinol is formed non-enzymatically when ethanol-derived acetaldehyde binds to dopamine, yielding 2 distinct products, i.e., salsolinol and isosalsolinol. Early animal studies, revealing that salsolinol ...