Now showing items 1-3 of 3

    • Angiotensin (1-7) decreases myostatin-induced NF-kappa B signaling and skeletal muscle atrophy 

      Aravena, Javier; Abrigo, Johanna; González, Francisco; Aguirre, Francisco; González, Andrea; Simon Pino, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)
      Myostatin is a myokine that regulates muscle function and mass, producing muscle atrophy. Myostatin induces the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. The main pathway that mediates ...
    • Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor 

      Abrigo, Johanna; González, Francisco; Aguirre, Francisco; Tacchi, Franco; González, Andrea; Meza, María Paz; Simón, Felipe; Cabrera, Daniel; Arrese, Marco; Karpen, Saúl; Cabello Verrugio, Claudio (Wiley, 2020)
      Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle-specific E3 ligases, atrogin-1 and MuRF-1, and ...
    • NNZ-2566, a Novel Analog of (1–3) IGF-1, as a Potential Therapeutic Agent for Fragile X Syndrome 

      Deacon, Robert; Glass, Larry; Snape, Mike; Hurley, Michael; Altimiras González, Francisco; Biekofsky, Rodolfo; Cogram, Patricia (Springer, 2015)
      Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. Previous studies have implicated mGlu5 in the pathogenesis of the disease, and many agents that target the underlying pathophysiology of ...