Now showing items 1-19 of 19

    • A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway 

      Zamorano, Sebastián; Rojas Rivera, Diego; Lisbona, Fernanda; Parra, Valentina; Court, Felipe A.; Villegas, Rosario; Cheng, Emily H.; Korsmeyer, Stanley J.; Lavandero González, Sergio; Hetz Flores, Claudio (2012)
      Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
    • Autofagia del cardiomiocito: ¿Un nuevo mecanismo de adaptación al estrés o de muerte celular? 

      Aránguiz Urroz, Pablo Daniel; Contreras Ferrat, Ariel Eduardo; Rojas Rivera, Diego; Troncoso Cotal, Rodrigo Hernán; Marambio Morales, Paola Angélica; Toro, Bárbara; Sanhueza Muñoz, Carlos Joaquín; Pennanen Saavedra, Christian; Díaz Elizondo, Jessica; Parra Ortíz, María Valentina; Chiong Lay, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)
      Históricamente, la apoptosis y la necrosis han sido consideradas como las dos formas fundamentales de muerte celular. Sin embargo, evidencias recientes sugieren que la muerte celular programada no está confinada sólo a ...
    • BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1 alpha 

      Lisbona, Fernanda; Rojas Rivera, Diego; Thielen, Peter; Zamorano, Sebastián; Todd, Derrick; Martinon, Fabio; Glavic Maurer, Álvaro; Kress, Christina; Lin, Jonathan H.; Walter, Peter; Reed, John C.; Glimcher, Laurie H.; Hetz Flores, Claudio (CELL PRESS, 2009-03-27)
      Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal transduction pathway known as the unfolded protein response (UPR). Bax inhibitor-1 (BI-1) is an evolutionarily conserved ...
    • BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α 

      Lisbona, Fernanda; Rojas Rivera, Diego; Thielen, Peter; Zamorano, Sebastian; Todd, Derrick; Martinon, Fabio; Glavic Maurer, Álvaro; Kress, Christina; Lin, Jonathan H.; Walter, Peter; Reed, John C.; Glimcher, Laurie H.; Hetz Flores, Claudio (2009)
      Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal transduction pathway known as the unfolded protein response (UPR). Bax inhibitor-1 (BI-1) is an evolutionarily conserved ...
    • BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response 

      Castillo, Karen; Rojas Rivera, Diego; Lisbona, Fernanda; Caballero, Benjamín; Nassif, Melissa; Court, Felipe A.; Schuck, Sebastian; Ibar, Consuelo; Walter, Peter; Sierralta, Jimena; Glavic Maurer, Álvaro; Hetz Flores, Claudio (2011)
      Both autophagy and apoptosis are tightly regulated processes playing a central role in tissue homeostasis. Bax inhibitor 1 (BI-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (ER) ...
    • Bax Inhibitor-1-mediated Ca2+leak is decreased by cytosolic acidosis 

      Kiviluoto, Santeri; Luyten, Tomas; Schneider, Lars; Lisak, Dmitrij; Rojas Rivera, Diego; Welkenhuyzen, Kirsten; Missaen, Ludwig; Smedt, Humbert De; Parys, Jan B.; Hetz Flores, Claudio; Methner, Axel; Bultynck, Geert (Elsevier, 2013)
      tBax Inhibitor-1 (BI-1) is an evolutionarily conserved six-transmembrane domain endoplasmic reticulum(ER)-localized protein that protects against ER stress-induced apoptotic cell death. This function is closelyconnected ...
    • BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α 

      Rodriguez, Diego A.; Zamorano, Sebastian; Lisbona, Fernanda; Rojas Rivera, Diego; Urra, Hery; Cubillos-Ruiz, Juan R.; Armisen Yáñez, Ricardo; Henriquez, Daniel R.; Cheng, Emily; Letek, Michal; Vaisar, Tomas; Irrazabal, Thergiory; González Billault, Christian; Letai, Antho (2012)
      Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor inositol-requiring enzyme 1α(IRE1α), which functions as an endoribonuclease that splices the ...
    • Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease 

      Dufey, Estefanie; Sepúlveda, Denisse; Rojas Rivera, Diego; Hetz Flores, Claudio (American Physiological Society, 2014)
      Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 1. An overview. Am J Physiol Cell Physiol 307: C582–C594, 2014. First published August 20, 2014; doi:10.1152/ajpcell.00258.2014.—Increased ...
    • Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview 

      Dufey, Estefanie; Sepúlveda, Denisse; Rojas Rivera, Diego; Hetz Flores, Claudio (American Physiological Society, 2014)
      © 2014 the American Physiological Society. Increased demand on the protein folding capacity of the endoplasmic reticulum (ER) engages an adaptive reaction known as the unfolded protein response (UPR). The UPR regulates ...
    • ER stress sensing mechanism: Putting off the brake on UPR transducers 

      Rojas Rivera, Diego; Rodríguez, Diego A.; Sepúlveda, Denisse; Hetz Flores, Claudio (Impact Journals LLC, 2018)
    • IGF-1: Un factor de crecimiento con acciones cardiovasculares pleiotrópicas. 

      Contreras Ferrat, Ariel Eduardo; Aránguiz Urroz, Pablo Daniel; Díaz Elizondo, Jessica; Chiong Lay, Mario; Muñoz, Juan Pablo; Parra Ortíz, María Valentina; Ibarra, Cristián; Rojas Rivera, Diego; Troncoso Cotal, Rodrigo; Eisner, Verónica; Salas, Daniela; Rodríguez Villarroel, Andrea Elizabeth; Carrasco Alarcón, Loreto del Pilar; Díaz Araya, Guillermo; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)
      El factor de crecimiento análogo a insulina tipo 1 (IGF-1) es un péptido relacionado estructural y funcionalmente con insulina que posee efectos mitogénicos y citoprotectores. Sus efectos biológicos dependen de la activación ...
    • Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat 

      Rodríguez, Diego A.; Rojas Rivera, Diego; Hetz Flores, Claudio (Elsevier, 2011-04)
      The assembling of distinct signaling protein complexes at the endoplasmic reticulum (ER) membrane controls several stress responses related to calcium homeostasis. autophagy, ER morphogenesis and protein folding. Diverse ...
    • Interactome screening identifies the ER luminal chaperone Hsp47 as a regulator of the unfolded protein response transducer IRE1 alpha 

      Sepúlveda, Denisse; Rojas Rivera, Diego; Rodríguez, Diego; Kohler, Andrés; Urra, Hery; Carreras Sureda, Amado; Hazari, Younis; Sierralta, Jimena; Hetz Flores, Claudio (Cell Press, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling network known as the unfolded protein response (UPR). IRE1a is a major UPR transducer, determining cell fate under ER stress. We ...
    • Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α 

      Sepulveda, Denisse; Rojas Rivera, Diego; Rodríguez, Diego A.; Groenendyk, Jody; Köhler, Andres; Lebeaupin, Cynthia; Ito, Shinya; Urra, Hery; Carreras-Sureda, Amado; Hazari, Younis; Vasseur-Cognet, Mireille; Ali, Maruf M.U.; Chevet, Eric; Campos, Gisela; Godoy, Patricio (Cell Press, 2018)
      © 2018 Elsevier Inc. Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling network known as the unfolded protein response (UPR). IRE1α is a major UPR transducer, determining cell fate ...
    • Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis 

      Groenendyk, Jody; Peng, Zhenling; Dudek, Elzbieta; Fan, Xiao; Mizianty, Marcin J.; Dufey, Estefanie; Urra, Hery; Sepulveda, Denisse; Rojas-Rivera, Diego; Lim, Yunki; Kim, Do Han; Baretta, Kayla; Srikanth, Sonal; Gwack, Yousang; Ahnn, Joohong; Kaufman, Randal J.; Lee, Sun (American Association for the Advancement of Science, 2014)
      The disruption of the energy or nutrient balance triggers endoplasmic reticulum (ER) stress, a process that mobilizes various strategies, collectively called the unfolded protein response (UPR), which reestablish homeostasis ...
    • Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis 

      Nassif, Melissa; Valenzuela, Vicente; Rojas Rivera, Diego; Vidal, René; Matus, Soledad; Castillo, Karen; Fuentealba, Yerko; Kroemer, Guido; Levine, Beth; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)
      Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis ...
    • Reactive oxygen species inhibit hyposmotic stress-dependent volume regulation in cultured rat cardiomyocytes 

      Díaz Elizondo, Jessica; Chiong Lay, Mario; Rojas Rivera, Diego; Olea Azar, Claudio; Kwon, H. Moo; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2006-12-01)
      Cells have developed compensatory mechanisms to restore cell volume, and the ability to resist osmotic swelling or shrinkage parallels their resistance to necrosis or apoptosis. There are several mechanisms by which cells ...
    • TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis 

      Rojas Rivera, Diego; Armisen Yáñez, Ricardo; Colombo, A.; Martínez, G.; Eguiguren, A. L.; Díaz, A.; Kiviluoto, S.; Rodríguez, D.; Patron, M.; Rizzuto, R.; Bultynck, G.; Concha, M. L.; Sierralta, J.; Stutzin Schottlander, Andrés; Hetz Flores, Claudio (2012)
      Transmembrane BAX inhibitor motif-containing (TMBIM)-6, also known as BAX-inhibitor 1 (BI-1), is an anti-apoptotic protein that belongs to a putative family of highly conserved and poorly characterized genes. Here we report ...
    • TMBIM3/GRINA: un gen regulado por la respuesta a proteínas mal plegadas (UPR) que inhibe la apoptosis mediante la modulación de la homeostasis del calcio 

      Rojas Rivera, Diego (Universidad de Chile, 2012)
      La familia de proteínas TMBIM (del inglés TransMembrane Bax-Inhibitor 1 Motive) es altamente conservada y ha sido pobremente caracterizada. Los genes de la familia TMBIM están presente en mamíferos, insectos, plantas y ...