Browsing by Author "90ef748c-967c-4818-8718-3072b465d73b"

Now showing items 1-6 of 6

    • Amide-Linked C4″-saccharide modification of krn7000 provides potent stimulation of human invariant NKT cells ... 
      Saavedra Ávila, Noemí Alejandra; Keshipeddy, Santosh; Guberman-Pfeffer, Matthew J.; Pérez Gallegos, Ayax; Saini, Neeraj; Schafer, Carolina; Carreño, Leandro J.; Gascón, José A.; Porcelli, Steven A.; Howell, Amy R. (American Chemical Society, 2020)
      Activation of invariant natural killer T (iNKT) cells by α-galactosylceramides (α-GalCers) stimulates strong immune responses and potent anti-tumor immunity. Numerous modifications of the glycolipid structure have been ...
    • Dual modifications of alpha-galactosylceramide synergize to promote activation of human invariant natural ... 
      Chennamadhavuni, Divya; Saavedra-Avila, Noemi Alejandra; Carreño Marquez, Leandro J.; Guberman-Pfeffer, Matthew J.; Arora, Pooja; Yongqing, Tan; Koay, Hui-Fern); Godfrey, Dale I.; Keshipeddy, Santosh; Richardson, Stewart K.; Sundararaj, Srinivasan; Lo, Jae Ho; Wen, Xiangshu; Gascón, José A.; Yuan, Weiming; Rossjohn, Jamie; Le Nours, Jéroˆme; Porcelli, Steven A.; Howell, Amy R. (Cell press, 2018-05-17)
      Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications for augmenting immune responses against cancer and infections. Previous studies using mouse ...
    • Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to ... 
      Prados-Rosales, Rafael; Carreño, Leandro J.; Batista-Gonzalez, Ana; Baena, Andres; Venkataswamy, Manjunatha M.; Xu, Jiayong; Yu, Xiaobo; Wallstrom, Garrick; Mitchell Magee, D.; LaBaer, Joshua; Achkar, Jacqueline M.; Jacobs, William R.; Chan, John; Porcelli, Steven A.; (American Society for Microbiology, 2014)
      © 2014 Prados-Rosales et al.Pathogenic and nonpathogenic species of bacteria and fungi release membrane vesicles (MV), containing proteins, polysaccharides, and lipids, into the extracellular milieu. Previously, we ...
    • Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47 
      Saini, Neeraj; Baena, Andrés; Ng, Tony W.; Venkataswamy, Manjunatha; Kennedy, Steven C.; Kunnath Velayudhan, Shajo; Carreño Marquez, Leandro; Xu, Jiayong; Chan, John; Larsen, Michelle; Jacobs, William; Porcelli, Steven A. (Nature Publishing Group, 2016)
      Suppression of major histocompatibility complex (MHC) class II antigen presentation is believed to be among the major mechanisms used by Mycobacterium tuberculosis to escape protective host immune responses. Through a ...
    • Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents 
      Carreño Marquez, Leandro; Saavedra Ávila, Noemí; Porcelli, Steven A. (Nature Publishing Group, 2016)
      Certain types of glycolipids have been found to have remarkable immunomodulatory properties as a result of their ability to activate specific T lymphocyte populations with an extremely wide range of immune effector properties. ...
    • The Type of Growth Medium Affects the Presence of a Mycobacterial Capsule and Is Associated With Differences ... 
      Prados Rosales, Rafael; Carreño Márquez, Leandro Javier; Weinrick, Brian; Batista González, Ana; Glatman Freedman, Aarona; Jiayong, Xu; Chan, John; William R., Jacobs Jr.; Porcelli, Steven A.; Casadevall, Arturo (2016)
      Background. Bacillus Calmette-Guerin (BCG) vaccine is widely used for the prevention of tuberculosis, despite limited efficacy. Most immunological studies of BCG or Mycobacterium tuberculosis strains grow bacteria in the ...