Browsing by Author "9453f80b-3281-406d-a3dd-828cd1a4d642"
Now showing items 1-9 of 9
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Lagos, Néstor; Valdés, Fernando; Orrego, Fernando (1983)The possible existence of endogenous substances other than γ-aminobutyric acid (GABA), that can also bind to rat brain GABA receptors, has been investigated in synaptic membranes derived from whole rat brain, or from ...
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Riveros, Nora; Orrego, Fernando (1982)Conditions were found for stabilizing rat brain cortex kainic acid (KA) receptors. Such receptors had the same Hill number (about 0.6) for KA and for glutamate. The receptors were then used as detectors for endogenous ...
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Lackington, Inés; Orrego, Fernando (1986)Net K fluxes in in vitro suspensions of sliced rat brain cortex were studied by means of a K-sensitive electrode. When incubation was in 3 mM K, a net K efflux occurred. It could be resolved into two first-order rate ...
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Wyneken, Ursula; Riquelme, Gloria; Villanueva, Sergio; Orrego, Fernando (Elsevier Ireland Ltd, 1997)Postsynaptic densities (PSDs) were isolated from rat brain cortex and hippocampus, purified and incorporated into giant (5-80 μm in diameter) liposomes. Gigaohm seals were obtained with a patch-clamp pipette, and a giant ...
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Ferreira, Jorge; Gil, Lionel; Stutzin Schottlander, Andrés; Orrego, Fernando (1985)Guanethidine at 5-25 mM concentrations was found to induce up to 79% inhibition of ADP-stimulated (state III) oxygen consumption in isolated rat heart, brain or liver mitochondria, when the added substrate was glutamate ...
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Berdichevsky, Elisa; Riveros, Nora; Sánchez-Armáss, Sergio; Orrego, Fernando (1983)Kainate (0.62-5 mM) was found to increase the initial rate of influx of 45Ca and of 22Na into the non-inulin space of rat thin brain cortex slices incubated in vitro, and to shorten the equilibration time for both these ...
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Soto, Dagoberto; Pancetti, Floria; Marengo, Juan José; Sandoval, Mauricio; Sandoval, Rodrigo; Orrego, Fernando; Wyneken, Ursula (2004)Protein kinase CK2 (CK2) is highly expressed in rat forebrain where its function is not well understood. Subcellular distribution studies showed that the catalytic subunit of CK2 (CK2α) was enriched in postsynaptic densities ...
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Valdes, Fernando; Orrego, Fernando (1970)THE excitatory action of strychnine on the central nervous system results from its ability to antagonize the effect of synaptic inhibition1. Recently, evidence has accumulated for glycine as an inhibitory transmitter, ...
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Valdés, Fernando; Muñoz, Carlos; Feria-Velasco, Alfredo; Orrego, Fernando (1977)The subcellular distribution of the membrane components, present in rat brain cortex homogenates, that interact with glycine in the presence of sodium ions was studied. The distribution in the primary fractions, as per ...