Browsing by Author "94ea481f-724a-4021-809d-439efe40e586"

Now showing items 1-4 of 4

    • Elevated testosterone induces apoptosis in neuronal cells 
      Estrada, Manuel; Varshney, Anurag; Ehrlich, Barbara E. (2006)
      Testosterone plays a crucial role in neuronal function, but elevated concentrations can have deleterious effects. Here we show that supraphysiological levels of testosterone (micromolar range) initiate the apoptotic cascade. ...
    • GDF-11 prevents cardiomyocyte hypertrophy by maintaining the sarcoplasmic reticulum-mitochondria communication 
      Garrido-Moreno, Valeria; Díaz Vegas, Alexis; López Crisosto, Camila; Troncoso, Mayarling Francisca; Navarro Márquez, Mario F.; García Nannig, Lorena; Estrada, Manuel; Cifuentes, Mariana; Lavandero González, Sergio (Academic Press, 2019)
      Growth differentiation factor 11 (GDF11) is a novel factor with controversial effects on cardiac hypertrophy both in vivo and in vitro. Although recent evidence has corroborated that GDF11 prevents the development of cardiac ...
    • GDF11 Modulates Ca2+-Dependent Smad2/3 signaling to prevent cardiomyocyte hypertrophy 
      Durán, Javier; Troncoso, Mayarling Francisca; Lagos, Daniel; Ramos, Sebastian; Marin, Gabriel; Estrada, Manuel (MDPI, 2018-05)
      Growth differentiation factor 11 (GDF11), a member of the transforming growth factor- family, has been shown to act as a negative regulator in cardiac hypertrophy. Ca2+ signaling modulates cardiomyocyte growth; however, ...
    • Sarcopenia and androgens: A link between pathology and treatment 
      Basualto-Alarcón, Carla; Varela, Diego; Duran, Javier; Maass, Rodrigo; Estrada, Manuel (Frontiers Media S.A., 2014)
      © 2014 Basualto-Alarcón, Varela, Duran, Maass and Estrada.Sarcopenia, the age-related loss of skeletal muscle mass and function, is becoming more prevalent as the lifespan continues to increase in most populations. As ...