Now showing items 1-17 of 17

    • Biological basis for cerebral dysfunction in schizophrenia in contrast with Alzheimer's disease 

      Kuljiš, Rodrigo O.; Colom, Luis V.; Rojo, Leonel E. (Frontiers Media, 2014)
      Schizophrenia and Alzheimer’s disease are two disorders that, while conceptualized as pathophysiologically and clinically distinct, cause substantial cognitive and behavioral impairment worldwide, and target apparently ...
    • Chitosan-based nanoparticles for Intracellular delivery of ISAV fusion protein cDNA into melanoma cells: a path to develop oncolytic anticancer therapies 

      Robles Planells, Claudia; Sánchez-Guerrero, Giselle; Barrera Ávalos, Carlos; Matiacevich, Silvia; Rojo, Leonel E.; Pavéz, Jorge; Salas Huenuleo, Edison; Kogan, Marcelo J.; Escobar Álvarez, Alejandro; Milla, Luis A.; Fernández, Ricardo; Imarai, Mónica; Spencer, Eugenio; Huidobro Toro, Juan Pablo; Acuña Castillo, Claudio (Hindawi, 2020)
      Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation ...
    • Cognitive impairment and Alzheimer's disease: Links with oxidative stress and cholesterol metabolism 

      Sekler, Maria Alejandra; Jiménez, José M.; Rojo, Leonel; Pastene, Edgard; Fuentes, Patricio; Slachevsky Chonchol, Andrea; Maccioni Baraona, Ricardo (2008)
      Oxidative stress has been implicated in the progression of a number of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease and amyotrophic lateral sclerosis. We carried out an in-depth study ...
    • Cognitive impairment and Alzheimer's disease: Links with oxidative stress and cholesterol metabolism 

      Sekler, Alejandra; Jiménez, José M.; Rojo, Leonel; Pastene, Edgard; Fuentes, Patricio; Slachevsky Chonchol, Andrea; Maccioni Baraona, Ricardo (BioMed Central, 2008)
      Oxidative stress has be en implicated in the progression of a number of neurodegenerative diseases, inc1uding Alzheimer's disease (AD), Parkinson's disease and amyotrophic lateral sclerosis. We carried out a~ in-depth ...
    • Dead tumor cells expressing infectious salmon anemia virus fusogenic protein favor antigen cross-priming in vitro 

      Morales, Jonathan; Barrera Avalos, Carlos; Castro, Carlos; Castillo, Stephanie; Barrientos, Claudio; Robles Planells, Claudia; López, Ximena; Torres, Ernesto; Montoya, Margarita; Cortez San Martin, Marcelo; Riquelme, Denise; Escobar Álvarez, Alejandro; Fernández, Ricardo; Imarai, Mónica; Sauma Mahaluf, Daniela; Rojo, Leonel E.; Leiva Salcedo, Elias; Acuña Castillo, Claudio (Frontiers media SA, 2017)
      Antigen cross-presentation is a crucial step in the assembly of an antitumor immune response leading to activation of naive CD8 T cells. This process has been extensively used in clinical trials, in which dendritic cells ...
    • From Molecules to the Clinic: Linking Schizophrenia and Metabolic Syndrome through Sphingolipids Metabolism 

      Castillo, Rolando I.; Rojo, Leonel E.; Henríquez Henríquez, Marcela; Silva Ibarra, Hernán; Maturana Hurtado, Alejandro; Villar, María J.; Fuentes, Manuel; Gaspar Ramos, Pablo (Frontiers Media, 2016)
      Metabolic syndrome (MS) is a prevalent and severe comorbidity observed in schizophrenia (SZ). The exact nature of this association is controversial and very often accredited to the effects of psychotropic medications and ...
    • Insulin Resistance and Alzheimer's Disease: Molecular Links & Clinical Implications 

      Neumann, Karen F.; Rojo, Leonel; Navarrete, Leonardo P.; Farías, Gonzalo; Reyes, Paula; Maccioni Baraona, Ricardo (BENTHAM SCIENCE PUBL LTD, 2008-10)
      Hyperinsulinemia as well as type II diabetes mellitus are among the risk factors for Alzheimer´s disease (AD). However, the molecular and cellular basis that link insulin resistance disorders and diabetes with AD are far ...
    • Metabolic syndrome and antipsychotics: The role of mitochondrial fission/fusion imbalance 

      Campo, Andrea del; Bustos, Catalina; Mascayano, Carolina; Acuña Castillo, Claudio; Troncoso, Rodrigo; Rojo, Leonel E. (Frontiers Media SA, 2018)
      Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There ...
    • Metabolic syndrome and obesity among users of second generation antipsychotics: A global challenge for modern psychopharmacology 

      Rojo, Leonel E.; Gaspar, Pablo A.; Silva, H.; Risco., L.; Arena, Pamela; Cubillos Robles, Karen; Jara, Belén (Elsevier, 2015)
      Second generation antipsychotics (SGAs), such as clozapine, olanzapine, risperidone and quetiapine, are among the most effective therapies to stabilize symptoms schizophrenia (SZ) spectrum disorders. In fact, clozapine, ...
    • Mifepristone for treatment of metabolic syndrome: beyond cushing’s syndrome 

      Díaz Castro, Francisco; Monsalves Álvarez, Matías; Rojo, Leonel E.; Campo, Andrea del; Troncoso, Rodrigo (Frontiers Media, 2020)
      A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic ...
    • Mild cognitive impairment and Alzheimer patients display different levels of redox-active CSF iron 

      Lavados Montes, Manuel; Guillón Moretti, Marta; Mujica, María Cristina; Rojo, Leonel; Fuentes, Patricio; Maccioni Baraona, Ricardo (IOS PRESS, 2008)
      Oxidative stress constitutes a hallmark of Alzheimer’s disease (AD). Recent studies also point to redox active metals such as iron, copper and zinc in mediating oxidative stress in AD pathogenesis. However, the reactivity ...
    • Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease 

      Rojo, Leonel E.; Fernández, Jorge A.; Maccioni, Andrea A.; Jiménez, José M.; Maccioni Baraona, Ricardo (2008)
      During the past few years, an increasing set of evidence has supported the major role of deregulation of the interaction patterns between glial cells and neurons in the pathway toward neuronal degeneration. Neurons and ...
    • Neuroinflammation: Implications for the pathogenesis and molecular diagnosis of Alzheimer's disease 

      Rojo, Leonel; Fernández Darraz, Jorge; Maccioni, Andrea A.; González Jiménez, José; Maccioni Baraona, Ricardo (ELSEVIER SCIENCE INC, 2007-05-31)
      During the past few years, an increasing set of evidence has supported the major role of deregulation of the interaction patterns between glial cells and neurons in the pathway toward neuronal degeneration. Neurons and ...
    • The Role of Neuroimmunomodulation in Alzheimer's Disease 

      Maccioni Baraona, Ricardo; Rojo, Leonel; Fernández, Jorge A.; Kuljis, Rodrigo O. (BLACKWELL, 2009)
      The idea that alterations in the brain immunomodulation are critical for Alzheimer’s disease (AD) pathogenesis provides the most integrative view on this cognitive disorder, considering that converging research lines ...
    • Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease 

      Rojo, Leonel E.; Sjoberg, Marcela; Hernández, Paula; Zambrano, Cristian; Maccioni Baraona, Ricardo (HINDAWI PUBLISHING CORPORATION, 2006)
      Alzheimer's disease is the principal cause of dementia throughout the world and the fourth cause of death in developed economies. This brain disorder is characterized by the formation of brain protein aggregates, namely, ...
    • Selective interaction of lansoprazole and Astemizole with tau polymers: Potential new clinical use in diagnosis of Alzheimer's disease 

      Rojo, Leonel E.; Alzate Morales, Jans; Saavedra, Iván N.; Davies, Peter; Maccioni Baraona, Ricardo (IOS Press, 2010)
      We describe the interactions of two benzimidazole derivatives, astemizole (AST) and lansoprazole (LNS), with anomalous aggregates of tau protein (neurofibrillary tangles). Interestingly, these compounds, with important ...
    • The damage signals hypothesis of Alzheimer's disease pathogenesis 

      Fernández, Jorge A.; Rojo, Leonel; Kuljis, Rodrigo O.; Maccioni Baraona, Ricardo (IOS Press, 2008)
      Virtually none of the hypotheses on Alzheimer's disease (AD) pathogenesis address the earliest events that trigger the molecular alterations that precede cerebral degeneration and account for the diversity of risk factors ...