Now showing items 1-16 of 16

    • Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls 

      Hernández, María Isabel; Martínez Aguayo, Alejandro; Cavada Chacón, Gabriel; Peña Novoa, Verónica; Trejo, León; Ávila, Alejandra; Salazar Cornejo, Teresa; Asenjo, Sylvia; Iñíguez Vila, Germán; Rey, Rodolfo; Mericq, Verónica (De Gruyter, 2013)
      Aim: To compare pubertal development in age-matched healthy girls born with low birth weight (LBW) or appropriate birth weight for gestational age (AGA). Subjects and methods: Girls with breast in Tanner stage II and ...
    • Aldosterone, plasma renin activity, and aldosterone/renin ratio in a normotensive healthy pediatric population 

      Martínez Aguayo, Alejandro; Aglony, Marlene; Campino, Carmen; Garcia, Hernan; Bancalari, Rodrigo; Bolte, Lillian; Avalos, Carolina; Loureiro, Carolina; Carvajal, Cristian A.; Avila, Alejandra; Perez, Viviana; Inostroza, Andrea; Fardella, Carlos E. (2010)
      Primary aldosteronism is an important cause of secondary hypertension and is suspected in adults with an aldosterone/renin ratio ≥25. The normal aldosterone/renin ratio is unknown in children. The aim was to establish serum ...
    • Comparison of leptin levels, body composition and insulin sensitivity and secretion by OGTT in healthy, early pubertal girls born at either appropriate- or small-for-gestational age 

      Martínez Aguayo, Alejandro; Capurro, T.; Peña, V.; Iñíguez Vila, Germán; Hernández, M. I.; Avila, A.; Salazar, T.; Asenjo, S.; Mericq, Verónica (2007)
      Background: Small for gestational age (SGA) has been associated with decreased insulin sensitivity (IS). A possible mechanism is the postnatal development of a metabolically disadvantageous body composition (BC). Aim: To ...
    • Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension 

      Martínez Aguayo, Alejandro; Campino, Carmen; Baudrand, René; Carvajal, Cristian; Garcia, Hernán; Aglony, Marlene; Bancalari, Rodrigo; García Nannig, Lorena; Loureiro, Carolina; Vecchiola, Andrea; Tapia Castillo, Alejandra; Valdivia, Carolina; Sanhueza, Sebastián; Fuentes, Cristóbal; Lagos, Carlos F.; Solari, Sandra; Allende, Fidel; Kalergis, Alexis; Fardella, Carlos E. (Lippincott Williams & Wilkins, 2016)
      Objective: To identify novel biomarkers associated with pediatric primary hypertension. Methods: We recruited 350 participants (4-16 years). Anthropometric parameters and aldosterone, plasma renin activity, cortisol, ...
    • The Expression of RAC1 and Mineralocorticoid Pathway- Dependent Genes are Associated With Different Responses to Salt Intake 

      Tapia Castillo, Alejandra; Carvajal, Cristian; Campino, Carmen; Hill, Caroline; Allende, Fidel; Vecchiola, Andrea; Carrasco, Carmen; Bancalari, Rodrigo; Valdivia, Carolina; Lagos, Carlos; Martínez Aguayo, Alejandro; García, Hernán; Aglony, Marlene; Baudrand, René; Kalergis, Alexis; Michea Acevedo, Luis; Riedel, Claudia; Fardella, Carlos (Oxford University Press, 2015)
      BACKGROUND Rac1 upregulation has been implicated in salt-sensitive hypertension as a modulator of mineralocorticoid receptor (MR) activity. Rac1 could affect the expression of oxidative stress markers, such as ...
    • Frequency of familial hyperaldosteronism type 1 in a hypertensive pediatric population: Clinical and biochemical presentation 

      Aglony, Marlene; Martínez-Aguayo, Alejandro; Carvajal, Cristian A.; Campino, Carmen; García, Hernán; Bancalari, Rodrigo; Bolte, Lillian; Avalos, Carolina; Loureiro, Carolina; Trejo, Pamela; Brinkmann, Karin; Giadrosich, Vinka; Mericq, Verónica; Rocha, Ana; Avila, Aleja (Lippincott Williams and Wilkins, 2011)
      Familial hyperaldosteronism type 1 is an autosomal dominant disorder attributed to a chimeric CYP11B1/CYP11B2 gene (CG). Its prevalence and manifestation in the pediatric population has not been established. We aimed to ...
    • How to optimally manage growth hormone therapy: Survey of chilean pediatric endocrinologists 

      García, Roberto J.; Martínez Aguayo, Alejandro; Mericq, Verónica (2012)
      Early referral is the key to the optimal management of growth failure. Evidence shows that there is no universal consensus for endocrinologists on the handling, tracking and monitoring of growth hormone (GH) treatment. The ...
    • Leuprolide acetate gonadotrophin response patterns during female puberty 

      Martínez Aguayo, Alejandro; Hernández Cárdenas, María Isabel; Capurro Spadaro, María Teresa; Peña Novoa, Verónica; Ávila, Alejandra; Salazar, T.; Asenjo, S.; Iñíguez Vila, Germán; Mericq, Verónica (Blackwell, 2010)
      Objective To assess normative data and the usefulness of spontaneous and LHRH analogue-stimulated serum LH and FSH levels measured by immunoradiometric assays (IRMA) in the evaluation of normal puberty. Design Prospective. ...
    • Leuprolide acetate-stimulated androgen response during female puberty 

      Hernández Cárdenas, María Isabel; Martínez Aguayo, Alejandro; Cavada Chacón, Gabriel; Ávila, Alejandra; Iñíguez Vila, Germán; Mericq, Verónica (Wiley & Sons, 2015)
      BackgroundA physiological increase in androgen levels occurs during adolescence. Measuring androgen concentrations is the best method to distinguish normal evolution processes from hyperandrogenic disorders. HypothesisThe ...
    • Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus 

      Codner Dujovne, Ethel; Rocha, Ana; Deng, Liyong; Martínez Aguayo, Alejandro; Godoy Cortés, Claudia; Mericq, Verónica; Chung, Wendy K. (WILEY-BLACKWELL PUBLISHING, 2009-09)
      Background: Incidental hyperglycemia in children generates concern about the presence of preclinical type I diabetes mellitus (T1DM). Objective: To genetically evaluate two corm-non forms of maturity-onset diabetes of ...
    • Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a chilean pediatric population 

      Tapia Castillo, Alejandra; Carvajal, Cristian A.; Campino, Carmen; Vecchiola, Andrea; Allende, Fidel; Solari, Sandra; García Nannig, Lorena; Lavandero González, Sergio; Valdivia, Carolina; Fuentes, Cristobal; Lagos, Carlos F.; Martínez Aguayo, Alejandro; Baudrand, René; Aglony, Marlene; García, Hernán; Fardella, Carlos E. (Oxford University Press, 2014)
      The GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) ...
    • Prevalence of hypertension in school age children and its association with obesity Prevalencia de hipertensión arterial y su asociación con la obesidad en edad pediátrica 

      Bancalari, Rodrigo; Díaz, Carlos; Martínez Aguayo, Alejandro; Aglony, Marlene; Zamorano, Juanita; Cerda, Verónica; Fernández, Manuel; Garbin, Flabia; Cavada Chacón, Gabriel; Valenzuela, María; García, Hernán (2011)
      Background: Hypertension in children is a frequently overlooked problem that is an important cardiovascular risk factor. Aim: To determine the prevalence of hypertension among school age children. Material and Methods: ...
    • Sodium intake is associated with endothelial damage biomarkers and metabolic dysregulation 

      Campino, Carmen; Baudrand, Rene; Valdivia, Carolina; Carvajal, Cristian; Vecchiola, Andrea; Tapia Castillo, Alejandra; Martínez Aguayo, Alejandro; Garcia, Hernán; García Nannig, Lorena; Allende, Fidel; Solari, Sandra; Fuentes, Cristóbal; Lagos, Carlos; Rojas, Maria; Muñoz, Doris; Fardella, Carlos E. (Oxford University Press, 2018)
      BACKGROUND : Mounting evidence has associated high sodium (HS) intake with hypertension, cardiovascular disease, and stroke. We investigated whether HS intake modulates the parameters of endothelial damage, inflammation, ...
    • Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia 

      Martínez Aguayo, Alejandro; Rocha, A.; Rojas, N.; García, C.; Parra R., Bélgica; Lagos, M.; Valdivia, L.; Poggi, H.; Cattani, Andreína; Alcazar, M. L.; Lacourt, P.; Cassorla Goluboff, Fernando; Codner Dujovne, Ethel; Escobar, E.; Gaete, X.; García, H.; Silva, R.; Giadrosich, V.; Godoy, C.; Ugarte, (Endocrine Society, 2007)
      Context: Infertility observed in adult males with congenital adrenal hyperplasia (CAH) has been associated with testicular adrenal rest tumors (TART) that may originate during childhood. Objective: Our objective was to ...
    • The expression of RAC1 and mineralocorticoid pathway-dependent genes are associated with different responses to salt intake 

      Tapia Castillo, Alejandra; Carvajal, Cristian A.; Campino, Carmen; Hill, Caroline; Allende, Fidel; Vecchiola, Andrea; Carrasco, Carmen; Bancalari, Rodrigo; Valdivia, Carolina; Lagos, Carlos; Martínez Aguayo, Alejandro; Garcia, Hernan; Aglony, Marlene; Baudrand, Rene F (Oxford University Press, 2015)
      © American Journal of Hypertension, Ltd 2014. All rights reserved.Background Rac1 upregulation has been implicated in salt-sensitive hypertension as a modulator of mineralocorticoid receptor (MR) activity. Rac1 could affect ...
    • Tobacco, alcohol, and illicit drug use in adolescents with diabetes mellitus 

      Martínez Aguayo, Alejandro; Araneda, Juan Carlos; Fernandez, Daniela; Gleisner, Andrea; Perez, Virginia; Codner Dujovne, Ethel (2007)
      Background: Substance abuse in adolescents with diabetes mellitus (DM) is associated with the development of acute and chronic complications. Objective: To determine the prevalence of alcohol, tobacco, and illicit drug ...