Now showing items 1-19 of 19

    • Adquirir habilidades no manejo de crises de hipertermia maligna: comparacao de simulacao de alta-fidelidade versus estudo de caso em computador 

      Mejía Díaz, Vilma; González, Carlos; Delfino, Alejandro; Altermatt, Fernando; Corvetto, Marcia (Sociedade Brasileira de Anestesiologia, 2018)
      Introduction: The primary purpose of this study was to compare the effect of high fidelity simulation versus a computer-based case solving self-study, in skills acquisition about malignant hyperthermia on first year ...
    • Anion permeation in human CIC-4 channels 

      Hebeisen, Simon; Heidtmann, Hannelore; Cosmelli, Diego; González, Carlos; Poser, Barbara; Latorre, Ramón; Álvarez Araya, Osvaldo; Fahlke, Christoph (BIOPHYSICAL SOCIETY, 2003-04)
      CIC-4 and CIC-5 are mammalian CIC isoforms with unique ion conduction and gating properties. Macroscopic current recordings in heterologous expression systems revealed very small currents at negative potentials, whereas a ...
    • Apoptosis en tumor venéreo transmisible del canino en fase de crecimiento progresivo y durante regresión inducida por vincristina 

      González, Carlos; Cepeda, Raquel; Flores Pavez, Estefanía; Cattaneo Univaso, Federico; Reyes, Susana (Universidad de Chile, 2003)
      Apoptosis or programmed cell death is a mechanism of cell elimination when they are unnecessary or genetically damaged. It is controlled by a variety of genes, many of which present mutation or dysfunstion associated to ...
    • Ca2+-activated K+ channel inhibition by reactive oxygen species 

      Soto, Marco A.; González, Carlos; Lissi Gervaso, Eduardo A.; Vergara Montecinos, Cecilia; Latorre, Ramón (AMER PHYSIOLOGICAL SOC, 2002-03)
      We studied the effect of H2O2 on the gating behavior of large-conductance Ca2+-sensitive voltage-dependent K+ (K-V,K-Ca) channels. We recorded potassium currents from single skeletal muscle channels incorporated into ...
    • Counting channels: a tutorial guide on ion channel fluctuation analysis 

      Álvarez Araya, Osvaldo; González, Carlos; Latorre, Ramón (American Physiological Society, 2002)
      Ion channels open and close in a stochastic fashion, following the laws of probability. However, distinct from tossing a coin or a die, the probability of finding the channel closed or open is not a fixed number but can ...
    • Effects of iconic gestures on the working memory of students with mild intellectual disability Efectos de los gestos icónicos en la memoria de trabajo de estudiantes con discapacidad intelectual leve 

      Muñoz Quezada, María Teresa; Lucero, Boris; González, Carlos (2010)
      The paper reviews how gestures influence the working memory of students with mild intellectual disability. Our general hypothesis is that retention of verbal information in working memory will vary as a function of the use ...
    • Increased production of soluble TLR2 by lamina propria mononuclear cells from ulcerative colitis patients 

      Candia, Enzo; Díaz Jiménez, David; Langjahr, Patricia; Núñez, Lucía E.; De la Fuente, Marjorie; Farfán, Nancy; López Kostner, Francisco; Abedrapo, Mario; Alvarez Lobos, Manuel; Pinedo, George; Beltrán, Caroll J.; González, Carlos; González Burgos, María Julieta; Quera Pino, Rodrigo (2012)
      Toll-like receptor 2 (TLR2) is a type I pattern recognition receptor that has been shown to participate in intestinal homeostasis. Its increased expression in the lamina propria has been associated with the pathogenesis ...
    • Inflammation, synovial angiogenesis and chondroid apoptosis in the evolution of type II collagen-induced arthritis 

      González, Carlos; Abello, Paula; Cepeda, Raquel; Salazar, Lorena; Aravena, Octavio; Pesce Reyes, Bárbara; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (2007)
      Using the murine model of type II collagen-induced arthritis (CIA), we studied its evolution over time by histopathological, immunohistochemical and clinical evaluations. The first clinical symptoms appeared 28 days ...
    • Modulation of the Shaker K+ channel gating kinetics by the S3-S4 linker 

      González, Carlos; Rosenman, Eduardo; Bezanilla, Francisco; Álvarez Araya, Osvaldo; Latorre, Ramón (ROCKEFELLER UNIV PRESS, 2000-02)
      In Shaker K+ channels depolarization displaces outwardly the positively charged residues of the S4 segment. The amount of this displacement is unknown, but large movements of the S4 segment should be con strained by the ...
    • Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1 

      Latorre, Ramón; Olcese, Riccardo; Basso, Claudia; González, Carlos; Muñoz, Fabián; Cosmelli, Diego; Álvarez Araya, Osvaldo (ROCKEFELLER UNIV PRESS, 2003-10)
      Animal and plant voltage-gated ion channels share a common architecture. They are made up of four subunits and the positive charges on helical S4 segments of the protein in animal K+ channels are the main voltage-sensing ...
    • Ovine placenta at high altitudes: Comparison of animals with different times of adaptation to hypoxic environment 

      Parraguez Gamboa, Víctor; Atlagich, Miljenko; Díaz, Rodrigo; Cepeda, Raquel; González, Carlos; Reyes Solovera, Mónica de los; Bruzzone Valdés, María Eugenia; Behn Thiele, Claus; Raggi Saini, Luis (ELSEVIER, 2006-09)
      Fetal growth and newborn weight from ovine gestations at high altitudes (HA) are greater in ewes that live at HA for several generations than in those native to low altitudes (LA) exposed to HA only during pregnancy. Because ...
    • Periodic perturbations in Shaker K+ channel gating kinetics by deletions in the S3-S4 linker 

      González, Carlos; Rosenman, Eduardo; Bezanilla, Francisco; Álvarez Araya, Osvaldo; Latorre, Ramón (NATL ACAD SCIENCES, 2001-08-14)
      Upon depolarization positive charges contained in the transmembrane segment S4 of voltage-dependent channels are displaced from the cytoplasmic to the external milieu, This charge movement leads to channel opening. In ...
    • Properties of the voltage-gated proton channel gating currents 

      Carmona, Emerson M.; Baez Nieto, David; Pupo, Amaury; Castillo, Karen; Álvarez Araya, Osvaldo; Neely, Alan; Latorre, Ramón; González, Carlos (Cell Press, 2018)
    • Temperature and voltage coupling to channel opening in transient receptor potential melastatin 8 (TRPM8) 

      Raddatz, Natalia; Castillo, Juan P.; González, Carlos; Álvarez Araya, Osvaldo; Latorre, Ramón (American Society for Biochemistry and Molecular Biology Inc., 2014)
      © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Expressed in somatosensory neurons of the dorsal root and trigeminal ganglion, the transient receptor potential melastatin 8 (TRPM8) channel is a ...
    • Temperature and Voltage Coupling to TRPM8 Channel Opening 

      Castillo, Juan; González, Carlos; Álvarez Araya, Osvaldo; Latorre, Ramón (Cell Press, 2015)
    • Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy 

      Cavieres, Viviana A.; González, Alexis; Muñoz, Vanessa C.; Yefi, Claudia P.; Bustamante, Hianara A.; Barraza, Rafael R.; Tapia Rojas, Cheril; Otth, Carola; Barrera, María José; González, Carlos; Mardones, Gonzalo A.; Inestrosa, Nibaldo C.; Burgos, Patricia V. (Public Library Science, 2015)
      Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-beta (A beta) peptide. We have previously shown that the compound tetrahydrohyperforin (IDN5706) prevents accumulation ...
    • The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels 

      García, Isaac E.; Villanelo, Felipe; Contreras, Gustavo F.; Pupo, Amaury; Pinto, Bernardo I.; Contreras, Jorge E.; Pérez-Acle, Tomás; Alvarez, Osvaldo; Latorre, Ramón; Martínez, Agustín D.; González, Carlos (Rockefeller University Press, 2018)
      © 2018 García et al. Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular ...
    • Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity 

      Hager Ribeiro, Carolina; López Bartolucci, Carolina; Ramírez Toloza, Galia; Valck Calderón, Carolina Eliana; Molina, María Carmen; Aguilar, Lorena; Rodríguez, Margarita; Maldonado, Ismael; Martínez, Ramón; González, Carlos; Troncoso Cotal, Rodrigo Andrés; Lavandero González, Sergio; Gingras, Alexandre R.; Schwaeble, Wilhelm; Ferreira, Arturo (PERGAMON-ELSEVIER SCIENCE LTD, 2009-03)
      Trypanosoma cruzi (T cruzi) is the causative agent of Chagas' disease, an endemic and chronic illness that affects 18 million people in Latin America. The mechanisms underlying its pathogenesis are controversial. There is ...
    • Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity 

      Ribeiro, Carolina Hager; López, Nandy C.; Ramírez, Galia A.; Valck, Carolina E.; Molina, María Carmen; Aguilar, Lorena; Rodríguez, Margarita; Maldonado, Ismael; Martínez, Ramón; González, Carlos; Troncoso, Rodrigo; Lavandero González, Sergio; Gingras, Alexandre R.; Schwaeble, Wilhelm (2009)
      Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas' disease, an endemic and chronic illness that affects 18 million people in Latin America. The mechanisms underlying its pathogenesis are controversial. There ...