Browsing by Author "9937ea52-0a8e-413b-a08c-297cd9390d06"

Now showing items 1-9 of 9

    • Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations 
      Mollereau, B.; Rzechorzek, N. M.; Roussel, B. D.; Sedru, M.; Van den Brink, D. M.; Bailly-Maitre, Beatrice; Palladino, F.; Medinas Bilches, Danilo; Domingos, P. M.; Hunot, S.; Chandran, S.; Birman, S.; Baron, T.; Vivien, D.; Duarte, C. D.; Ryoo, H. D.; Steller, H.; Urano, F.; Chevet, E.; Kroemer, G.; Ciechanover, A.; Calabrese, E. J.; Kaufman, R. J.; Hetz Flores, Claudio (Elsevier, 2016)
      In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations ...
    • Creutzfeldt-jakob disease. Report of one case Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob. ... 
      Ramírez, Marcos; Gallardo, Andrés; Vidal, Aarón; Cornejo, Sebastián; Ramírez, Darío; Medinas Bilches, Danilo; Bustamante, Gonzalo; Pasquali, Renzo; Hetz Flores, Claudio (Sociedad Medica de Santiago, 2016)
      © 2016, Sociedad Medica de Santiago. All rights reserved. Creutzfeldt-Jakob disease has a higher incidence in Chile than in other countries. The post mortem pathological characterization of brain tissue is necessary to ...
    • Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob. Caso clínico 
      Ramírez, Marcos; Gallardo, Andrés; Vidal, Aarón; Cornejo, Sebastián; Ramírez, Darío; Medinas Bilches, Danilo; Bustamante Fontecilla, Gonzalo; Pasquali, Renzo; Hetz Flores, Claudio (Soc Médica Santiago, 2016)
      Creutzfeldt-Jakob disease has a higher incidence in Chile than in other countries. The post mortem pathological characterization of brain tissue is necessary to reach a definitive diagnosis. We report a 73 years old man ...
    • Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43(A315T) ALS/FTD mouse model 
      Bargsted, Leslie; Medinas Bilches, Danilo; Martínez Traub, Francisca; Rozas, Pablo; Muñoz, Natalia; Nassif, Melissa; Jerez, Carolina; Catenaccio, Alejandra; Court, Felipe A.; Hetz Flores, Claudio; Matus, Soledad (Nature Publishing Group, 2017)
      Tar DNA binding protein 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tissue of most cases of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ...
    • ER stress links aging to sporadic ALS 
      Medinas Bilches, Danilo; Cabral Miranda, Felipe; Hetz Flores, Claudio (Impact Journals LLC, 2019)
    • Fine-tuning ER stress signal transducers to treat amyotrophic lateral sclerosis 
      Medinas Bilches, Danilo; González, José V.; Falcon, Paulina; Hetz Flores, Claudio (Frontiers Media SA, 2017)
      Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motoneurons and paralysis. The mechanisms underlying neuronal degeneration in ALS are starting to be elucidated, ...
    • IRE1 signaling exacerbates Alzheimer's disease pathogenesis 
      Durán Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Alvaro O.; Medinas Bilches, Danilo; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G.; Hoozemans, Jeroen J. M.; Hetz Flores, Claudio (Springer, 2017)
      Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded ...
    • Proteostasis disturbance in amyotrophic lateral sclerosis 
      Medinas Bilches, Danilo; Valenzuela Paterakis, Vicente; Hetz Flores, Claudio (Oxford University Press, 2017)
      Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motoneurons in the brain and spinal cord leading to paralysis and death. Although the etiology of ALS remains poorly understood, ...
    • The ER proteostasis network in ALS: Determining the differential motoneuron vulnerability 
      Rozas, Pablo; Bargsted, Leslie; Martínez, Francisca; Hetz Flores, Claudio; Medinas Bilches, Danilo (Elsevier Ireland Ltd, 2017)
      © 2016 Elsevier Ireland Ltd Amyotrophic lateral sclerosis (ALS) is a fatal late-onset neurodegenerative disease characterized by the selective loss of motoneurons. The mechanisms underlying neuronal degeneration in ALS are ...