Browsing by Author "99a2d231-6991-42af-9e42-341fcc2c0532"

Now showing items 1-11 of 11

    • Amyotrophic lateral sclerosis pathogenesis: A journey through the secretory pathway 
      Nassif, Melissa; Matus, Soledad; Castillo, Karen; Hetz Flores, Claudio (2010)
      Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motoneuron degenerative disease characterized by the selective loss of motoneurons in the spinal ventral horn, most brainstem nuclei, and the cerebral ...
    • Autophagy impairment: A crossroad between neurodegeneration and tauopathies 
      Nassif, Melissa; Hetz Flores, Claudio (2012)
      Most neurodegenerative diseases involve the accumulation of misfolded proteins in the nervous system. Impairment of protein degradation pathways such as autophagy is emerging as a consistent and transversal pathological ...
    • BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response 
      Castillo, Karen; Rojas Rivera, Diego; Lisbona, Fernanda; Caballero, Benjamín; Nassif, Melissa; Court, Felipe A.; Schuck, Sebastian; Ibar, Consuelo; Walter, Peter; Sierralta, Jimena; Glavic Maurer, Álvaro; Hetz Flores, Claudio (2011)
      Both autophagy and apoptosis are tightly regulated processes playing a central role in tissue homeostasis. Bax inhibitor 1 (BI-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (ER) ...
    • Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43(A315T) ALS/FTD mouse model 
      Bargsted, Leslie; Medinas Bilches, Danilo; Martínez Traub, Francisca; Rozas, Pablo; Muñoz, Natalia; Nassif, Melissa; Jerez, Carolina; Catenaccio, Alejandra; Court, Felipe A.; Hetz Flores, Claudio; Matus, Soledad (Nature Publishing Group, 2017)
      Tar DNA binding protein 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tissue of most cases of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ...
    • Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein 
      Gómez, Wileidy; Morales, Rodrigo; Maracaja Coutinho, Vinicius; Parra Ortiz, Valentina; Nassif, Melissa (Impact Journals LLC, 2020)
      Alzheimer’s disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the leading genetic risk factor for Early-Onset AD, prematurely presenting the classic pathological features of the brain with AD. ...
    • Outside in: Unraveling the role of neuroinflammation in the progression of Parkinson's disease 
      Troncoso-Escudero, Paulina; Parra, Alejandra; Nassif, Melissa; Vidal, Rene L. (Frontiers Media S.A., 2018)
      Copyright © 2018 Troncoso-Escudero, Parra, Nassif and Vidal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other ...
    • Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis 
      Nassif, Melissa; Valenzuela, Vicente; Rojas Rivera, Diego; Vidal, René; Matus, Soledad; Castillo, Karen; Fuentealba, Yerko; Kroemer, Guido; Levine, Beth; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)
      Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis ...
    • Targeting autophagy in ALS: A complex mission 
      Nassif, Melissa; Hetz Flores, Claudio (Taylor and Francis Inc., 2011)
      Several neurodegenerative diseases share a common neuropathology, primarily featuring the presence of abnormal protein inclusions in the brain containing specific misfolded proteins. Strategies to decrease the load of ...
    • Unraveling the role of motoneuron autophagy in ALS 
      Valenzuela, Vicente; Nassif, Melissa; Hetz Flores, Claudio (Taylor and Francis Inc., 2018)
      © 2018 Informa UK Limited, trading as Taylor & Francis Group. In recent years, the role of autophagy in the pathogenesis of most neurodegenerative diseases has transitioned into a limbo of protective or detrimental effects. ...
    • XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy 
      Hetz Flores, Claudio; Thielen, Peter; Matus, Soledad; Nassif, Melissa; Court, Felipe; Kiffin, Roberta; Martinez, Gabriela; Cuervo, Ana María; Brown, Robert H.; Glimcher, Laurie H. (2009)
      Mutations in superoxide dismutase-1 (SOD1) cause familial amyotrophic lateral sclerosis (fALS). Recent evidence implicates adaptive responses to endoplasmic reticulum (ER) stress in the disease process via a pathway known ...
    • XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy 
      Matus, Soledad; Nassif, Melissa; Glimcher, Laurie H.; Hetz Flores, Claudio (Taylor and Francis Inc., 2009)
      Endoplasmic reticulum (ER) stress has been extensively described in many protein misfolding disorders including amyotrophic lateral sclerosis (ALS). Adaptation to ER stress is mediated by the activation of an integrated ...