Browsing by Author "XX631156"
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A ciliary K+ conductance sensitive to charibdotoxin underlies inhibitory responses in toad olfactory receptor neurons
(1995)In olfactory neurons from Caudiverbera caudiverbera, a mixture of putrid odorants trigger an inhibitory, K+-selective current and a hyperpolarizing receptor potential. The current-voltage relation resembles that of a ... -
A CLCA regulatory protein present in the chemosensory cilia of olfactory sensory neurons induces a Ca2+ -activated Cl- current when transfected into HEK293
(BIOMED Central Ltd., 2017)Background: CLCA is a family of metalloproteases that regulate Ca2+-activated Cl- fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed ... -
Altered voltage dependent calcium currents in a neuronal cell line derived from the cerebral cortex of a trisomy 16 fetal mouse, an animal model of down syndrome
(2012)Human Down syndrome (DS) is determined by the trisomy of autosome 21 and is expressed by multiple abnormalities, being mental retardation the most striking feature. The condition results in altered electrical membrane ... -
Amplitude modulation patterns of local field potentials reveal asynchronous neuronal populations
(2007)Neural oscillations, which appear in several areas of the nervous system and cover a wide frequency range, are a prominent issue in current neuroscience. Extracellularly recorded oscillations are generally thought to be a ... -
Apoptosis induced by prolonged exposure to odorants in cultured cells from rat olfactory epithelium
(ELSEVIER, 2006-08-04)Multicellular organisms undergo programmed cell death (PCD) as a mechanism for tissue remodeling during development and tissue renewal throughout adult life. Overdose of some neuronal receptor agonists like glutamate can ... -
Ca2+-Activated Cl2 Channels of the ClCa Family Express in the Cilia of a Subset of Rat Olfactory Sensory Neurons
(PLoS ONE, 2013)The Ca2+-activated Cl2 channel is considered a key constituent of odor transduction. Odorant binding to a specific receptor in the cilia of olfactory sensory neurons (OSNs) triggers a cAMP cascade that mediates the opening ... -
Ca2+-dependent K+ channels from rat olfactory cilia characterized in planar lipid bilayers
(ELSEVIER SCIENCE BV, 2005-03-14)Olfactory cilia contain cyclic nucleotide-gated and Ca2+-dependent Cl- conductances that underlie excitatory chemotransduction, and a Ca2+-dependent K+ (K-Ca) conductance, apparently involved in inhibitory transduction. ... -
Calcium mediates the activation of the inhibitory current induced by odorants in toad olfactory receptor neurons
(1997)In toad olfactory neurons, a putrid odorant mixture inducing inhibitory responses increases Ca2+-activated K+ conductance, developing a hyperpolarizing receptor potential. Removal of extracellular Ca2+ or exposure to ... -
Calcium mediates the NO-induced potassium current in toad and rat olfactory receptor neurons
(2000)Nitric oxide (NO) activates a K+ current in dissociated amphibian olfactory receptor neurons. Using the patch-clamp technique in its whole-cell mode and stimulation with puffs of the NO-donor sodium nitroprusside, we further ... -
Cellular & molecular Ca2+ microdomains in olfactory cilia support low signaling amplification of odor transduction
(2010)Signal transduction depends critically on the spatial localization of protein constituents. A key question in odor transduction is whether chemotransduction proteins organize into discrete molecular complexes throughout ... -
Cilium-attached and excised patch-clamp recordings of odourant-activated Ca-dependent K channels from chemosensory cilia of olfactory receptor neurons
(2004)It has previously been proposed that a Ca2+-dependent K + conductance is implicated in the inhibitory odourant response in rat and toad olfactory receptor neurons. Previous whole-cell and single-channel measurements on ... -
Coordinated gating of TRP-dependent channels in rhabdomeral membranes from Drosophila retinas
(Society for Neuroscience, 2000)Using a newly developed dissociation procedure, we isolated the specialized rhabdomeral membranes from Drosophila retinal photoreceptors. From these membranes, we have recorded spontaneous active currents in excised patch, ... -
Current issues in invertebrate phototransduction: Second messengers and ion conductances
(Humana Press, 1997)Investigation of phototransduction in invertebrate photoreceptors has revealed many physiological and biochemical features of fundamental biological importance. Nonetheless, no complete picture of phototransduction has yet ... -
Cyclic AMP cascade mediates the inhibitory odor response of isolated toad olfactory receptor neurons
(AMER PHYSIOLOGICAL, 2005-09)Odor stimulation may excite or inhibit olfactory receptor neurons (ORNs). It is well established that the excitatory response involves a cyclic AMP (cAMP) transduction mechanism that activates a nonselective cationic cyclic ... -
Diacylglycerol Activates the Light-Dependent Channel TRP in the Photosensitive Microvilli of Drosophila melanogaster Photoreceptors
(Society for Neuroscience, 2014)Drosophila light-dependent channels, TRP and TRPL, reside in the light-sensitive microvilli of the photoreceptor’s rhabdomere. Phospholipase C mediates TRP/TRPL opening, but the gating process remains unknown. Controversial ... -
Electrical resonance in the h frequency range in olfactory amygdala neurons
(PLOS One, 2014)The cortical amygdala receives direct olfactory inputs and is thought to participate in processing and learning of biologically relevant olfactory cues. As for other brain structures implicated in learning, the principal ... -
Energy requirements of odor transduction in the chemosensory cilia of olfactory sensory neurons rely on oxidative phosphorylation and glycolytic processing of extracellular glucose
(Soc Neuroscience, 2017-06-07)The mechanisms that power the physiological events occurring in cilia, flagella, and microvilli are of fundamental importance for the functions of these important and ubicuous organelles. The olfactory epithelium is mostly ... -
Estudio de la activación de los canales TRP de fotorreceptores de Drosophila por lípidos derivados del Diacilglicerol
(Universidad de ChileCyberDocs, 2010)Los sistemas biológicos de transducción de señales comparten mecanismos celulares conservados en diversos organismos. El estudio de los sistemas visuales de insectos, como el de la mosca Drosophila melanogaster, ha permitido ... -
Excitation, inhibition, and suppression by odors in isolated toad and rat olfactory receptor neurons
(2000)Vertebrate olfactory receptor neurons (ORNs) exhibit odor-induced increases in action potential firing rate due to an excitatory cAMP-dependent current. Fish and amphibian ORNs also give inhibitory odor responses, manifested ...
