• Advances in Fetal and Neonatal Physiology 

      Giussani, Dino A.; Niu, Youguo; Herrera Videla, Emilio; Richter, Hans G.; Camm, Emily J.; Thakor, Avnesh S.; Kane, Andrew D.; Hansell, Jeremy A.; Brain, Kirsty L.; Skeffington, Katie L.; Itani, Nozomi; Wooding, F. B. Peter; Cross, Christine M.; Allison, Beth J. (Springer, 2014)
      The quality of the intrauterine environment interacts with our genetic makeup to shape the risk of developing disease in later life. Fetal chronic hypoxia is a common complication of pregnancy. This chapter reviews how ...
    • Assessment of in vivo fetal growth and placental vascular function in a novel intrauterine growth restriction model of progressive uterine artery occlusion in guinea pigs 

      Herrera Videla, Emilio; Alegria, Rene; Farias, Marcelo; Diaz Lopez, Farah; Hernandez, Cherie; Uauy Dagach-Imbarack, Ricardo; Regnault, Timothy; Casanello, Paola; Krause, Bernardo (WILEY-BLACKWEL, 2016)
      Intra-uterine growth restriction (IUGR) is associated with short and long-term metabolic and cardiovascular alterations. Mice and rats have been extensively used to study the effects of IUGR, but there are notable differences ...
    • Caracterización de la función vascular de un modelo de restricción de crecimiento intra-uterino por oclusión progresiva de arterias uterinas en cobayas 

      Alegría Vera, René Augusto (Universidad de Chile, 2015)
      La restricción del crecimiento intrauterino (RCIU) es una causa importante de mortalidad y morbilidad perinatal. Una interacción compleja y dinámica del ambiente materno, la placenta y el feto está involucrado en asegurar ...
    • Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano 

      Herrera Videla, Emilio; Reyes, Roberto V.; Giussani, Dino A.; Sanhueza Reinoso, Emilia; Ebensperger, Germán; Casanello, Paola; Méndez, Natalia; Ebensperger, Renato; Sepúlveda Kattan, Esteban; Pulgar, Víctor M.; Cabello, Gertrudis; Llanos Mansilla, Jorge; Riquelme González, Raquel; Blanco, Carlos E.; Hanson, Mark A.; Parer, Julian T. (European Society of Cardiology, 2008)
      Aims To study the nitric oxide (NO) and carbon monoxide roles in the regulation of the pulmonary circulation in lowland and highland newborn sheep and llamas. Methods and results We used neonatal sheep (Ovis aries) and ...
    • Correlación interobservadores en interpretación de SPECT de perfusión con 99mTc-sestamibi en infarto agudo de miocardio reperfundido 

      Massardo Vega, Lucía; Lavados, H.; Jaimovich F., Rodrigo; Herrera Videla, Emilio; Quevedo, L.; Alfaro, L.; Assef, V.; Coll, C.; Velásquez, C.; Pereira, M. E.; Olea, E.; Quintana, Juan Carlos (Elsevier Science, 2008-03)
      Introducción y objetivos. La interpretación de la tomografía de emisión de fotón único (SPECT) de perfusión miocárdica requiere conocer la reproducibilidad de la técnica. El objetivo fue analizar la correlación ...
    • Epigenetic Programming of Cardiovascular Disease by Perinatal Hypoxia and Fetal Growth Restriction 

      Casanello, Paola; Herrera Videla, Emilio; Krause, Bernardo J. (INTECH, 2017)
      Most of the worldwide deaths in patients with non-communicable diseases are due to cardiovascular and metabolic diseases, which are determined by a mix of environmental, genetic and epigenetic factors, and by their ...
    • Evidence of a role for melatonin in fetal sheep physiology: direct actions of melatonin on fetal cerebral artery, brown adipose tissue and adrenal gland 

      Torres Farfán, Claudia; Valenzuela, Francisco J.; Mondaca, Mauricio; Valenzuela, Guillermo J.; Krause, Bernardo; Herrera Videla, Emilio; Seron Ferre, María Josefa; Riquelme González, Raquel; Llanos Mansilla, Jorge (BLACKWELL PUBLISHING, 2008-08-15)
      Although the fetal pineal gland does not secrete melatonin, the fetus is exposed to melatonin of maternal origin. In the non-human primate fetus, melatonin acts as a trophic hormone for the adrenal gland, stimulating ...
    • Evolving in thin air—Lessons from the llama fetus in the altiplano 

      Riquelme González, Raquel; Herrera Videla, Emilio; Ebensperger, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza Reinoso, Emilia; Pulgar, Víctor M.; Behn Thiele, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Llanos Mansilla, Jorge; Hanson, Mark A. (ELSEVIER, 2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the lowfetal arterial PO2 of all species, but also the likely ...
    • Fetal and postnatal pulmonary circulation in the Alto Andino 

      Ebensperger, G.; Herrera Videla, Emilio; Reyes, R. V.; Pulgar, V. M.; Seron Ferre, María Josefa; Díaz Beneventi, Mauricio; Parer, J. T.; Riquelme González, Raquel; Giussani, Dino A.; Moraga, F. A.; Llanos Mansilla, Jorge (Elsevier, 2011)
      Lowland mammals at high altitude constrict the pulmonary vessels, augmenting vascular resistance and developing pulmonary arterial hypertension. In contrast, highland mammals, like the llama, do not present pulmonary ...
    • Fetal brain hypometabolism during prolonged hypoxaemia in the llama 

      Ebensperger, Germán; Ebensperger, Renato; Herrera Videla, Emilio; Riquelme González, Raquel; Sanhueza Reinoso, Emilia; Lesage, Florian; Llanos Mansilla, Jorge; Marengo, Juan José; Tejo, Rodrigo; Reyes, Roberto (BLACKWELL PUBLISHING, 2005-09-15)
      In this study we looked for additional evidence to support the hypothesis that fetal llama reacts to hypoxaemia with adaptive brain hypometabolism. We determined fetal llama brain temperature, Na+ and K+ channel density ...
    • High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep 

      Herrera Videla, Emilio; Pulgar, Víctor M.; Llanos Mansilla, Jorge; Sanhueza Reinoso, Emilia; Reyes, Roberto V.; Ebensperger, Germán; Parer, Julian T.; Riquelme González, Raquel; Valdéz, Enrique A.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (AMER PHYSIOLOGICAL SOC, 2007-06)
      Perinatal exposure to chronic hypoxia induces sustained pulmonary hypertension and structural and functional changes in both pulmonary and systemic vascular beds. The aim of this study was to analyze consequences of ...
    • Impaired Nitric Oxide Mediated Vasodilation In The Peripheral Circulation In The R6/2 Mouse Model Of Huntington's Disease 

      Kane, Andrew D.; Niu, Youguo; Herrera Videla, Emilio; Morton, A. Jennifer; Giussani, Dino A. (Nature, 2016)
      Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular pathology pre-dates neurological decline, however ...
    • Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant maturation in male fetuses in late gestation 

      McGillick, Erin V.; Orgeig, Sandra; Allison, Beth J.; Brain, Kirsty L.; Niu, Youguo; Itani, Nozomi; Skeffington, Katie L.; Kane, Andrew D.; Herrera Videla, Emilio; Giussani, Dino A.; Morrison, Janna L. (Wiley, 2017)
      Chronic fetal hypoxaemia is a common pregnancy complication that may arise from maternal, placental and/or fetal factors. Respiratory outcome of the infant at birth likely depends on the duration, timing and severity of ...
    • Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs 

      Herrera Videla, Emilio; Macchiavello, Roberto; Montt, Camilo; Ebensperger Darrouy, Germán; Díaz Navarrete, Marcela; Ramírez, Santiago; Parer, Julian T.; Serrón Ferré, María; Reyes, Roberto V.; Llanos Mansilla, Jorge (John Wiley & Sons Ltd,, 2014)
      Chronic hypoxia during gestation and delivery results in oxidative stress and cerebrovascular dysfunction in the neonate. We assessed whether melatonin, a potent antioxidant and potential vasodilator, improves the cerebral ...
    • Melatonin modulates the fetal cardiovascular defense response to acute hypoxia 

      Thakor, Avnesh S.; Allison, Beth J.; Niu, Youguo; Botting, Kimberley J.; Serón Ferré, María; Herrera Videla, Emilio; Giussani, Dino A. (Wiley & Sons, 2015)
      Experimental studies in animal models supporting protective effects on the fetus of melatonin in adverse pregnancy have prompted clinical trials in human pregnancy complicated by fetal growth restriction. However, the ...
    • Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep 

      Torres, Flavio; González Candia, Alejandro; Montt, Camilo; Ebensperger Darrouy, Germán; Chubretovic, Magdalena; Serón Ferré, Maria Josefa; Reyes Catalán, Victor; Llanos Mansilla, Jorge; Herrera Videla, Emilio (Wiley, 2015)
      Pulmonary hypertension of the newborn (PHN) constitutes a critical condition with severe cardiovascular and neurological consequences. One of its main causes is hypoxia during gestation, and thus, it is a public health ...
    • Omega3 Supplementation and Intermittent Hypobaric Hypoxia Induce Cardioprotection Enhancing Antioxidant Mechanisms in Adult Rats 

      Herrera Videla, Emilio; Farías, Jorge; González Candia, Alejandro; Short, Stefania; Carrasco Pozo, Catalina; Castillo Peñaloza, Rodrigo (MDPI, 2015)
      Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing ...
    • Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress 

      Farías, Jorge; Herrera Videla, Emilio; Carrasco Pozo, Catalina; Sotomayor Zárate, Ramón; Cruz, Gonzalo; Morales Retamales, Paola; Castillo Peñaloza, Rodrigo (Pergamon-Elsevier, 2016)
      Hypoxia is the failure of oxygenation at the tissue level,where the reduced oxygen delivered is not enough to satisfy tissue demands. Metabolic depression is the physiological adaptation associated with reduced oxygen ...
    • Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses 

      Krause, Bernardo; Herrera Videla, Emilio; Díaz López, F. A.; Farías, M.; Uauy Dagach-Imbarack, Ricardo; Casanello, P. (Cambridge University Press, 2016)
      In humans, obesity before and during pregnancy is associated with both fetal macrosomia and growth restriction, and long-term cardiovascular risk in the offspring. We aimed to determine whether overweighted pregnant guinea ...
    • Pulmonary hypertension due to lung diseases and/or hypoxia: what do we actually know 

      Kosanovic, Djuro; Herrera Videla, Emilio; Sydykov, Akylbek; Orfanos, Stylianos E.; El Agha, Elie (Hindawi Ltda., 2017)