Now showing items 1-6 of 6

    • Actividad del citocromo P450 y su alteración en diversas patologías 

      Orellana Bown, Myriam; Guajardo Tobar, Viviana (SOC MEDICA SANTIAGO, 2004-01)
      Cytochrome P450 (CYP) enzymes participate in the metabolism of a variety of naturally occurring and foreign compounds by reactions requiring NADPH and O2. The diversity of reactions catalyzed and its extensive substrate ...
    • Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox 

      Faúndez, Mario; López Muñoz, Rodrigo; Torres, Gloria; Morello Casté, Antonio; Ferreira, Jorge; Kemmerling Weis, Ulrike; Orellana Bown, Myriam; Maya Arango, Juan (AMER SOC MICROBIOLOGY, 2008-05)
      L-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden ...
    • Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients 

      Videla Cabrera, Luis; Rodrigo Salinas, Ramón; Orellana Bown, Myriam; Fernandez, Virginia; Tapia Opazo, Gladys; Quiñones Sepúlveda, Luis; Varela Figueroa, Nelson; Contreras, Jorge; Lazarte, Raúl; Csendes Juhasz, Attila; Rojas Caro, Jorge; Maluenda, Fernando; Burdiles Pinto, Patricio; Díaz Jeraldo, Juan; Smok Sahid, Gladys; Thielemann, Lilian; Poniachik Teller, Jaime (Clinical Science, 2004-03)
      Oxidative stress is implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In the present study, hepatic and plasma oxidative stress-related parameters were measured and correlated with clinical and ...
    • Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women 

      Varela Figueroa, Nelson; Quiñones Sepúlveda, Luis; Orellana Bown, Myriam; Poniachik Teller, Jaime; Csendes Juhasz, Attila; Smok Sahid, Gladys; Rodrigo Salinas, Ramón; Cáceres Lillo, Dante; Videla Cabrera, Luis (SOC BIOLGIA CHILE, 2008)
      CYP2E1 enzyme is related to nonalcoholic steatohepatitis (NASH) due to its ability for reactive oxygen species production, which can be influenced by polymorphisms in the gene. The aim of this study was to investigate ...
    • Trypanosoma cruzi: Activities of lapachol and α- and β-lapachone derivatives against epimastigote and trypomastigote forms 

      Salas, Cristian; Tapia, Ricardo A.; Ciudad, Karina; Armstrong, Verónica; Orellana Bown, Myriam; Kemmerling Weis, Ulrike; Ferrada Parker, Jorge; Maya Arango, Juan; Morello Casté, Antonio (Elsevier Ltd, 2008-01-15)
      Derivatives of natural quinones with biological activities, such as lapachol, α- and β-lapachones, have been synthesized and their trypanocidal activity evaluated in vitro in Trypanosoma cruzi cells. All tested compounds ...
    • Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole 

      López Muñoz, Rodrigo; Faúndez, Mario; Klein, Sebastián; Escanilla, Sebastián; Torres, Gloria; Lee-Liu, Dasfne; Ferrada Parker, Jorge; Kemmerling Weis, Ulrike; Orellana Bown, Myriam; Morello, Antonio; Ferreira, Arturo; Maya Arango, Juan (ELSEVIER, 2010)
      Nifurtimox and benznidazole are the only active drugs against Trypanosoma cruzi; however, they have limited efficacy and severe side effects. During primoinfection, T. cruzi infected macrophages mount an antiparasitic ...