Browsing by Author "a3f9664a-76d2-4898-b1c3-3a383e1483cf"

Now showing items 1-6 of 6

    • BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α 
      Lisbona, Fernanda; Rojas Rivera, Diego; Thielen, Peter; Zamorano, Sebastian; Todd, Derrick; Martinon, Fabio; Glavic Maurer, Álvaro; Kress, Christina; Lin, Jonathan H.; Walter, Peter; Reed, John C.; Glimcher, Laurie H.; Hetz Flores, Claudio (2009)
      Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal transduction pathway known as the unfolded protein response (UPR). Bax inhibitor-1 (BI-1) is an evolutionarily conserved ...
    • Diminishing apoptosis by deletion of bax or overexpression of Bcl-2 does not protect against infectious ... 
      Steele, Andrew D.; King, Oliver D.; Jackson, Walker S.; Hetz Flores, Claudio; Borkowski, Andrew W.; Thielen, Peter; Wollmann, Robert; Lindquist, Susan (2007)
      B-cell lymphoma protein 2 (Bcl-2) and Bcl-2-associated X protein (Bax), key antiapoptotic and proapoptotic proteins, respectively, have important roles in acute and chronic models of neurologic disease. Several studies ...
    • Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal ... 
      García Huerta, Paula; Troncoso Escudero, Paulina; Wu, Di; Thiruvalluvan, Arun; Cisternas, Marisol; Henríquez, Daniel R.; Plate, Lars; Chana-Cuevas, Pedro; Saquel, Cristian; Thielen, Peter; Longo, Kenneth A.; Geddes, Brad J.; Lederkremer, Gerardo Z.; Sharma, Neeraj; Shenkman, Marina; Naphade, Swati; Sardi, S. Pablo; Spichiger, Carlos; Richter, Hans G.; Court, Felipe A.; Tshilenge, Kizito Tshitoko; Ellerby, Lisa M.; Wiseman, R. Luke; Gonzalez Billault, Christian; Bergink, Steven; Vidal, René L.; Hetz Flores, Claudio (Springer, 2020)
      Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription ...
    • IRE1 signaling exacerbates Alzheimer's disease pathogenesis 
      Durán Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Alvaro O.; Medinas Bilches, Danilo; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G.; Hoozemans, Jeroen J. M.; Hetz Flores, Claudio (Springer, 2017)
      Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded ...
    • Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis 
      Hetz Flores, Claudio; Lee, Ann Hwee; González Romero, Dennisse; Thielen, Peter; Castilla, Joaquín; Soto, Claudio; Glimcher, Laurie H. (2008)
      The unfolded protein response (UPR) is a conserved adaptive reaction that increases cell survival under endoplasmic reticulum (ER) stress conditions. X-box-binding protein-1 (XBP-1) is a key transcriptional regulator of ...
    • XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy 
      Hetz Flores, Claudio; Thielen, Peter; Matus, Soledad; Nassif, Melissa; Court, Felipe; Kiffin, Roberta; Martinez, Gabriela; Cuervo, Ana María; Brown, Robert H.; Glimcher, Laurie H. (2009)
      Mutations in superoxide dismutase-1 (SOD1) cause familial amyotrophic lateral sclerosis (fALS). Recent evidence implicates adaptive responses to endoplasmic reticulum (ER) stress in the disease process via a pathway known ...