Browsing by Author "a762d1c1-1e6d-4f5f-a126-49301d951c39"

Now showing items 1-3 of 3

    • ER chaperones in neurodegenerative disease: Folding and beyond 
      García Huerta, Paula; Bargsted, Leslie; Rivas, Alexis; Matus, Soledad; Vidal, René L. (Elsevier, 2016)
      Proteins along the secretory pathway are co-translationally translocated into the lumen of the endoplasmic reticulum (ER) as unfolded polypeptide chains. Afterwards, they are usually modified with N-linked glycans, correctly ...
    • Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal ... 
      García Huerta, Paula; Troncoso Escudero, Paulina; Wu, Di; Thiruvalluvan, Arun; Cisternas, Marisol; Henríquez, Daniel R.; Plate, Lars; Chana-Cuevas, Pedro; Saquel, Cristian; Thielen, Peter; Longo, Kenneth A.; Geddes, Brad J.; Lederkremer, Gerardo Z.; Sharma, Neeraj; Shenkman, Marina; Naphade, Swati; Sardi, S. Pablo; Spichiger, Carlos; Richter, Hans G.; Court, Felipe A.; Tshilenge, Kizito Tshitoko; Ellerby, Lisa M.; Wiseman, R. Luke; Gonzalez Billault, Christian; Bergink, Steven; Vidal, René L.; Hetz Flores, Claudio (Springer, 2020)
      Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription ...
    • The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases? 
      García Huerta, Paula; Troncoso Escudero, Paulina; Jerez, Carolina; Hetz Flores, Claudio; Vidal, René L. (Elsevier Science, 2016-10-15)
      One of the salient features of most neurodegenerative diseases is the aggregation of specific proteins in the brain. This proteostasis imbalance is proposed as a key event triggering the neurodegenerative cascade. The ...