Browsing by Author "ace52f33-55cf-4d09-8fa2-b53af1e7a4fe"

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    • Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures 
      Araujo, Fillipe M. de; Ferreir, Rafael S.; Souza, Cleide S.; Santos, Cleonice Creusa dos; Rodrigues, Tácio L. R. S.; Silva, Juliana Helena C. E.; Gasparotto, Juciano; Gelain, Daniel Pens; El-Bachá, Ramón S.; Costa, María de Fátima D.; Fonseca, José Claudio M.; Segura Aguilar, Juan; Costa, Silvia L.; Silva, Víctor Diógenes A. (Elsevier, 2018-05)
      Recent evidence shows that aminochrome induces glial activation related to neuroinflammation. This dopamine derived molecule induces formation and stabilization of alpha-synuclein oligomers, mitochondria dysfunction, ...
    • Aminochrome induces microglia and astrocyte activation 
      Santos, Cleonice C.; Araújo, Fillipe M.; Ferreira, Rafael S.; Silva, Vanessa B.; Silva, Juliana H.C.; Grangeiro, Maria S.; Soares, Érica N.; Pereira, Érica Patricia L.; Souza, Cleide S.; Costa, Silvia L.; Segura Aguilar, Juan; Silva, Victor Diogenes (Elsevier, 2017)
      Aminochrome has been suggested as a more physiological preclinical model capable of inducing five of the six mechanisms of Parkinson's Disease (PD). Until now, there is no evidence that aminochrome induces glial activation ...