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    • Activation of the NLRP3 inflammasome in dendritic cells induces IL-1Β-dependent adaptive immunity against tumors 

      Ghiringhelli, François; Apetoh, Lionel; Tesniere, Antoine; Aymeric, Laetitia; Ma, Yuting; Ortiz, Carla; Vermaelen, Karim; Panaretakis, Theocharis; Mignot, Grégoire; Ullrich, Evelyn; Perfettini, Jean Luc; Schlemmer, Frédéric; Tasdemir, Ezgi; Uhl, Martin; Génin, Pierre; León C., Paulo C. (Nature Publishing Group, 2009)
      The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs), which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)-producing T lymphocytes. Here we show ...