Now showing items 1-12 of 12

    • Functional interaction between human papillomavirus type 16 E6 and E7 oncoproteins and cigarette smoke components in lung epithelial cells 

      Muñoz, Juan Pablo; González, Carolina; Parra, Bárbara; Corvalán, Alejandro H.; Tornesello, Maria Lina; Eizuru, Yoshito; Aguayo, Francisco (2012)
      The smoking habit is the most important, but not a sufficient cause for lung cancer development. Several studies have reported the human papillomavirus type 16 (HPV16) presence and E6 and E7 transcripts expression in lung ...
    • Helicobacter pylori -induced inflammation and epigenetic changes during gastric carcinogenesis 

      Valenzuela, Manuel A.; Canales, Jimena; Corvalán, Alejandro H.; Quest, Andrew F. G. (WJG Press, 2015)
      © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. The sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". ...
    • Helicobacter pylori and epigenetic mechanisms underlying gastric carcinogenesis 

      Valenzuela, Manuel A.; Canales, Jimena; Corvalán, Alejandro H.; Quest, Andrew F. G. (Baishideng Publishing Group Inc., 2015)
      The sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". This cascade is a dynamic process that includes lesions, such as atrophic gastritis, ...
    • Helicobacter pylori-induced loss of the inhibitor-of-apoptosis protein survivin is linked to gastritis and death of human gastric cells 

      Valenzuela, Manuel; Pérez Pérez, Guillermo; Corvalán, Alejandro H.; Carrasco, Gonzalo; Urra, Hery; Bravo, Denisse; Toledo, Héctor; Quest, Andrew F. G. (2010)
      Helicobacter pylori infects the human stomach and modifies signaling pathways that affect gastric epithelial cell proliferation and viability. Chronic exposure to this pathogen contributes to the onset of gastric atrophy, ...
    • Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer 

      Cerda-Opazo, Paulina; Valenzuela Valderrama, Manuel; Wichmann, Ignacio; Rodríguez, Andrés; Contreras Reyes, Daniel Alberto; Fernández, Elmer A.; Carrasco Aviño, Gonzalo; Corvalán, Alejandro H.; Quest, Andrew F. G. (Impact Journals LLC, 2018)
      © Cerda-Opazo et al. BACKGROUND: The objective of the study was to determine the relationship between Survivin and Reprimo transcript/protein expression levels, and gastric cancer outcome. METHODS: In silico correlations ...
    • Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer 

      Saavedra, Kathleen; Valbuena, José; Olivares, Wilda; Marchant, María José; Rodríguez, Andrés; Torres Estay, Verónica; Carrasco Avino, Gonzalo; Guzmán, Leda; Aguayo González, Francisco; Roa, Juan Carlos; Corvalán, Alejandro H. (Public Library Science, 2015)
      Reprimo (RPRM), a downstream effector of p53-induced cell cycle arrest at G2/M, has been proposed as a putative tumor suppressor gene (TSG) and as a potential biomarker for non-invasive detection of gastric cancer (GC). ...
    • Merkel cell polyomavirus in non-small cell lung carcinomas from Chile 

      Gheit, Tarik; Muñoz, Juan Pablo; Levican, Jorge; González, Carolina; Ampuero Llanos, Sandra; Parra, Bárbara; Gaggero Brillouet, Aldo; Corvalán, Alejandro H.; Uribe Meneses, Manuel Ángel; Tommasino, Massimo; Aguayo, Francisco (2012)
      Lung cancer is a leading pathology strongly associated with the smoking habit. However, a viral etiology for a subset of patients developing lung cancer has been suggested. Polyomaviruses (PyVs) are small double stranded ...
    • MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer 

      Sandoval Borquez, Alejandra; Polakovicova, Iva; Carrasco Véliz, Nicolás; Lobos González, Lorena; Riquelme, Ismael; Carrasco Aviño, Gonzalo; Bizama, Carolina; Norero, Enrique; Owen, Gareth I.; Roa, Juan; Corvalán, Alejandro H. (Biomed Central Ltd., 2017)
      Background: Multiple aberrant microRNA expression has been reported in gastric cancer. Among them, microRNA-335-5p (miR-335), a microRNA regulated by DNA methylation, has been reported to possess both tumor suppressor and ...
    • Noncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers 

      Sandoval Bórquez, Alejandra; Saavedra, Kathleen; Carrasco Avino, Gonzalo; García Bloj, Benjamin; Fry, Jacqueline; Wichmann, Ignacio; Corvalán, Alejandro H. (Hindawi Publishing, 2015)
      Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death, whose patterns vary among geographical regions and ethnicities. It is a multifactorial disease, and its development depends ...
    • Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024 

      Ferreccio, Catterina; Roa, Juan Carlos; Bambs, Claudia; Vives, Alejandra; Corvalán, Alejandro H.; Cortés, Sandra; Foerster, Claudia; Acevedo, Johanna; Huidobro, Andrea; Passi, Alvaro; Toro, Pablo; Covacevich, Yerko; Cruz, Rolando de la; Koshiol, Jill; Olivares, Mauricio; Miquel, Juan Francisco; Cruz, Francisco; Silva, Raúl; Quest, Andrew F. G.; Kogan Bocian, Marcelo; Castro, Pablo F.; Lavandero González, Sergio (BioMed Central, 2016)
      Background: Maule Cohort (MAUCO), a Chilean cohort study, seeks to analyze the natural history of chronic diseases in the agricultural county of Molina (40,000 inhabitants) in the Maule Region, Chile. Molina's population ...
    • Tobacco smoke activates human papillomavirus 16 p97 promoter and cooperates with high-risk E6/E7 for oxidative DNA damage in lung cells 

      Peña, Nelson; Carrillo, Diego; Muñoz, Juan P.; Chnaiderman, Jonás; Urzúa, Ulises; León, Oscar; Tornesello, Maria L.; Corvalán, Alejandro H.; Soto Rifo, Ricardo; Aguayo, Francisco (Public Library of Science, 2015)
      © 2015 Peña et al. We have previously shown a functional interaction between human papillomavirus type 16 (HPV-16) E6 and E7 oncoproteins and cigarette smoke condensate (CSC) in lung cells suggesting cooperation during ...
    • Tobacco smoke activates human papillomavirus 16 p97 promoter and cooperates with high-risk E6/E7 for oxidative DNA damage in lung cells 

      Peña, Nelson; Carrillo, Diego; Muñoz, Juan P.; Chnaiderman, Jonás; Urzúa, Ulises; León, Oscar; Tornesello, Maria L.; Corvalán, Alejandro H.; Soto Rifo, Ricardo; Aguayo, Francisco (Public Library of Science, 2015)
      © 2015 Peña et al. We have previously shown a functional interaction between human papillomavirus type 16 (HPV-16) E6 and E7 oncoproteins and cigarette smoke condensate (CSC) in lung cells suggesting cooperation during ...