Browsing by Author "b02f5a82-f242-4645-b487-394e5c963bd4"

Now showing items 1-17 of 17

    • Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death 
      Sánchez, Gina; Berrios, Daniela; Olmedo, Ivonne; Pezoa, Javier; Riquelme, Jaime A.; Montecinos, Luis; Pedrozo Cibils, Zully; Donoso Laurent, Paulina (Public Library Science, 2016)
      Inhibitors of the ubiquitin-proteasome system improve hemodynamic parameters and decrease the infarct size after ischemia reperfusion. The molecular basis of this protection is not fully understood since most available ...
    • Aging impairs hippocampal- dependent recognition memory and LTP and prevents the associated RyR up-regulation 
      Arias Cavieres, Alejandra; Adasme, Tatiana; Sánchez, Gina; Muñoz, Pablo; Hidalgo Tapia, María Cecilia (Frontiers Research Foundation, 2017)
      © 2017 Arias-Cavieres, Adasme, Sánchez, Muñoz and Hidalgo.Recognition memory comprises recollection judgment and familiarity, two different processes that engage the hippocampus and the perirhinal cortex, respectively. ...
    • Autonomic imbalance in cardiac surgery: A potential determinant of the failure in remote ischemic preconditioning 
      Gajardo, Abraham I.J.; Karachon, Lukas; Bustamante, Pablo; Repullo, Pablo; Llancaqueo, Marcelo; Sánchez, Gina; Rodrigo Salinas, Ramón (Churchill Livingstone, 2018)
      © 2018 Elsevier Ltd Remote ischemic preconditioning (RIPC) is a cardioprotective strategy against myocardial damage by ischemia-reperfusion. Many in-vivo and ex-vivo animal researches have demonstrated that RIPC decreases ...
    • Ca2+/calmodulin kinase II increases ryanodine binding and Ca2+-induced sarcoplasmic reticulum Ca2+ release ... 
      Ferrero, Paola; Said, Matilde; Sánchez, Gina; Vittone, Leticia; Valverde, Carlos; Donoso Laurent, Paulina; Mattiazzi, Alicia; Mundiña-Weilenmann, Cecilia (2007)
      We aimed to define the relative contribution of both PKA and Ca2+/calmodulin-dependent protein kinase II (CaMKII) cascades to the phosphorylation of RyR2 and the activity of the channel during β-adrenergic receptor (βAR) ...
    • Calcium release mediated by redox-sensitive RyR2 channels has a central role in hippocampal structural ... 
      More, Jamileth Y.; Bruna, Barbara A.; Lobos, Pedro; Galaz, Jose L.; Figueroa, Paula L.; Namias, Silvia; Sánchez, Gina; Barrientos Briones, Genaro; Valdes Guerrero, Jose; Paula Lima, Andrea; Hidalgo Tapia, María Cecilia; Adasme, Tatiana (Mary Ann Liebert Inc publishers, 2018)
      Aims: Previous studies indicate that hippocampal synaptic plasticity and spatial memory processes entail calcium release from intracellular stores mediated by ryanodine receptor (RyR) channels. In particular, RyR-mediated ...
    • Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury 
      Zepeda Iriarte, Ramiro; Kuzmicic, Jovan; Parra Ortiz, Valentina; Troncoso Cotal, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Sánchez, Gina; Lavandero González, Sergio (Lippincott Williams and Wilkins, 2014)
      Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
    • Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: Possible role in ... 
      Sánchez, Gina; Escobar, Matías; Pedrozo Cibils, Zully; Macho Fisher, Pilar; Domenech Lira, Raúl; Härtel, Steffen; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (2008)
      Aim: Our objective was to investigate in cardiac muscle the contribution of NADPH oxidase to (a) ryanodine receptor-2 (RyR2) S-glutathionylation and (b) the preconditioning effects of exercise and tachycardia on infarct ...
    • Exercise induces early and late myocardial preconditioning in dogs 
      Domenech Lira, Raúl; Macho Fisher, Pilar; Schwarze, Hermann; Sánchez, Gina (2002)
      Objective: We tested the hypothesis that exercise induces myocardial preconditioning in dogs. Methods: We instrumented dogs with a snare on the anterior descending coronary artery and catheters in the root of the aorta, ...
    • High fat diet induced obesity produces spontaneous ventricular arrhythmias and increases the activity of ... 
      Sánchez, Gina; Araneda, Felipe; Peña, Juan Pedro; Finkelstein, José Pablo; Riquelme, Jaime A.; Montecinos, Luis; Barrientos Briones, Genaro; Llanos Vidal, Paola; Pedrozo Cibils, Zully; Said, Matilde; Bull Simpfendorfer, Ricardo; Donoso Laurent, Paulina (MDPI, 2018)
      Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, ...
    • Insulin/NFκB protects against ischemia-induced necrotic cardiomyocyte death 
      Díaz, Ariel; Humeres, Claudio; González, Verónica; Gómez, María Teresa; Montt, Natalia; Sánchez, Gina; Chiong Lay, Mario; García Nannig, Lorena (Academic Press Inc., 2015)
      In the heart, insulin controls key functions such as metabolism, muscle contraction and cell death. However, all studies have been focused on insulin action during reperfusion. Here we explore the cardioprotective action ...
    • Kinetic studies of calcium-induced calcium release in cardiac sarcoplasmic reticulum vesicles 
      Sánchez, Gina; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (Biophysical Society, 2003)
      Fast Ca2+ release kinetics were measured in cardiac sarcoplasmic reticulum vesicles actively loaded with Ca2+. Release was induced in solutions containing 1.2 mM free ATP and variable free [Ca2+] and [Mg2+]. Release rate ...
    • Preconditioning tachycardia decreases the activity of the mitochondrial permeability transition pore in the ... 
      Sánchez, Gina; Fernández, Carolina; Montecinos, Luis; Domenech Lira, Raúl; Donoso Laurent, Paulina (2011)
      Cardioprotection by preconditioning is a central issue of current research on heart function. Several reports indicate that preventing the assembly and opening of the mitochondrial permeability transition pore (mPTP) ...
    • Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1–9) through an AT2R and ... 
      Mendoza Torres, Evelyn; Riquelme, Jaime A.; Vielma, Alejandra; Sagredo, Andrea Ramirez; Gabrielli, Luigi; Bravo Sagua, Roberto; Jalil Milad, Jorge; Rothermel, Beverly A.; Sánchez, Gina; Ocaranza, María Paz; Lavandero González, Sergio (Academic Press, 2018)
      © 2018 Elsevier Ltd Angiotensin-(19), a peptide of the non-classical renin angiotensin system, has been shown to prevent and revert hypertension and cardiac hypertrophy. We hypothetized that systemic delivery of angiotensin-(1–9) ...
    • Redox regulation of calcium release in skeletal and cardiac muscle 
      Hidalgo Tapia, María Cecilia; Aracena, Paula; Sánchez, Gina; Donoso Laurent, Paulina (Society of Biology of Chile, 2002)
      In skeletal and cardiac muscle cells, specific isoforms of the Ryanodine receptor channels mediate Ca2+ release from the sarcoplasmic reticulum. These channels are highly susceptible to redox modifications, which regulate ...
    • Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused ... 
      Becerra, Romina; Román, Bárbara; Di Carlo, Mariano; Mariangelo, Juan Ignacio; Salas, Margarita; Sánchez, Gina; Donoso Laurent, Paulina; Schinella, Guillermo; Vittone, Leticia; Wehrens, Xander; Mundiña Weilenmann, Cecilia; Said, Matilde (American Physiological Society, 2016)
      Previous results from our laboratory showed that phosphorylation of ryanodine receptor 2 (RyR2) by Ca2+ calmodulin-dependent kinase II (CaMKII) was a critical but not the unique event responsible for the production of ...
    • Study of the behavioral effects of bilateral nucleus accumbens lesions on amphetamin and apomorphine in adult cats 
      Motles, Elías; Infante, Claudio; Sánchez, Gina; Gonzalez, Magali (1998)
      The aim of the present work was to study the effects of three different types of bilateral lesions performed on the nucleus accumbens, upon the behaviors elicited in adult cats by parenteral administration of amphetamine ...
    • Tachycardia preconditions infarct size in dogs: Role of adenosine and protein kinase C 
      Domenech Lira, Raúl; Macho Fisher, Pilar; Vélez, Diego; Sánchez, Gina; Liu, Xueliang; Dhalla, Naranjan (Lippincott Williams and Wilkins, 1998)
      Background - Myocardial ischemic preconditioning is a well-known phenomenon, however there is scant information in regard to nonischemic preconditioning. Methods and Results - We studied in anesthetized dogs the preconditioning ...