Now showing items 1-2 of 2

    • A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway 

      Zamorano, Sebastián; Rojas Rivera, Diego; Lisbona, Fernanda; Parra, Valentina; Court, Felipe A.; Villegas, Rosario; Cheng, Emily H.; Korsmeyer, Stanley J.; Lavandero González, Sergio; Hetz Flores, Claudio (2012)
      Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
    • Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia 

      Hetz Flores, Claudio; Vitte, Pierre-Alain; Bombrun, Agnes; Rostovtseva, Tatiana K.; Montessuit, Sylvie; Hiver, Agnes; Schwarz, Matthias K.; Church, Dennis J.; Korsmeyer, Stanley J.; Martinou, Jean-Claude (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2005-12)
      Ischemic injuries are associated with several pathological conditions, including stroke and myocardial infarction. Several studies have indicated extensive apoptotic cell death in the infarcted area as well as in the ...