Now showing items 1-3 of 3

    • Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-β signaling 

      Santibanez, Juan F.; Letamendia, Ainhoa; Perez-Barriocanal, Fernando; Silvestri, Cristoforo; Saura, Marta; Vary, Calvin P.H.; Lopez-Novoa, Jose M.; Attisano, Liliana; Bernabeu, Carmelo (2007)
      The endothelial nitric oxide synthase (eNOS) is a critical regulator of cardiovascular homeostasis, whose dysregulation leads to different vascular pathologies. Endoglin is a component of the transforming growth factor ...
    • Endoglin regulates cyclooxygenase-2 expression and activity 

      Jerkic, Mirjana; Rivas Elena, Juan V.; Santibáñez, Juan Francisco; Prieto, Marta; Rodríguez Barbero, Alicia; Pérez Barriocanal, Fernando; Pericacho, Miguel; Arévalo, Miguel; Vary, Calvin P.H.; Letarte, Michelle; Bernabeu, Carmelo; López Novoa, José M. (LIPPINCOTT WILLIAMS & WILKINS, 2006-08-04)
      The endoglin heterozygous (Eng(+/-)) mouse, which serves as a model of hereditary hemorrhagic telangiectasia (HHT), was shown to express reduced levels of endothelial NO synthase (eNOS) with impaired activity. Because of ...
    • The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras 

      Santibanez, Juan F.; Pérez-Gómez, Eduardo; Fernandez-L, Africa; Garrido-Martin, Eva M.; Carnero, Amancio; Malumbres, Marcos; Vary, Calvin P.H.; Quintanilla, Miguel; Bernabéu, Carmelo (Oxford University Press, 2010)
      Endoglin is a coreceptor for transforming growth factor-β (TGF-β) that acts as a suppressor of malignancy during mouse skin carcinogenesis. Because in this model system H-Ras activation drives tumor initiation and progression, ...