Browsing by Author "b6f90e58-5c9d-42bb-aaba-2ce062cde548"

Now showing items 1-14 of 14

    • A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor ... 
      Arancibia, Sergio; Espinoza, Cecilia; Salazar, Fabián; Del Campo, Miguel; Tampe, Ricardo; Zhong, Ta Ying; Ioannes, Pablo de; Moltedo, Bruno; Ferreira, Jorge; Lavelle, Ed C.; Manubens, Augusto; Ioannes, Alfredo de; Becker, María Inés (Public Library of Science, 2014)
      Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as immunomodulatory proteins with proven anti-cancer properties. The biodiversity of hemocyanins has promoted interest in identifying new ...
    • Antibacterial effect of kaempferol and (−)-epicatechin on Helicobacter pylori 
      Escandón, Ricardo; Del Campo, Miguel; López Solís, Remigio; Obreque Slier, Elías; Toledo, Héctor (Springer Verlag, 2016)
      Phenolic compounds are generated by the secondary metabolism of plants and have been associated with antibacterial properties. Among bacteria affecting human health, Helicobacter pylori has been associated with gastric ...
    • Concholepas hemocyanin biosynthesis takes place in the hepatopancreas, with hemocytes being involved in its ... 
      Manubens, Augusto; Salazar, Fabián; Haussmann, Denise; Figueroa, Jaime; Del Campo, Miguel; Pinto, Jonathan Martínez; Huaquín, Laura; Venegas, Alejandro; Becker, María Inés (2010)
      Hemocyanins are copper-containing glycoproteins in some molluscs and arthropods, and their bestknown function is O2 transport. We studied the site of their biosynthesis in the gastropod Concholepas concholepas by using ...
    • Determination of the toxic variability of lipophilic biotoxins in marine bivalve and gastropod tissues ... 
      García, Carlos; Oyaneder Terrazas, Javiera; Contreras, Cristobal; Del Campo, Miguel; Torres, Rafael; Contreras Muñoz, Héctor (Taylor & Francis, 2016)
      Contamination of shellfish with lipophilic marine biotoxins (LMB), pectenotoxins (PTXs), yessotoxins (YTXs) and okadaic acid (OA) toxin groups in southern Chile is a constant challenge for the development of miticulture ...
    • Effect of superior ovarian nerve and plexus nerve sympathetic denervation on ovarian-derived infertility ... 
      Del Campo, Miguel; Piquer, Beatriz; Witherington, Jason; Sridhar, Arun; Lara Peñaloza, Hernán (Frontiers Media S.A., 2019)
      Sympathetic innervation of the ovary in rodents occurs via two routes: the superior ovarian nerve (SON), which runs along the ovarian ligament, and the plexus nerve (PN), which is mainly associated with the vasculature. ...
    • Evaluation of Neosaxitoxin as a local anesthetic during piglet castration: A potential alternative for Lidocaine 
      Valenzuela, Carolina; Torres, Cristian; Muñoz, Vanina; Simbaina, Juan Carlos; Sánchez, Andrella; Bustamante, Tamara; Sepúlveda, Joaquín M.; Piron, Robin; Del Campo, Miguel; Lagos, Néstor (Elsevier Ltd, 2019)
      Objetive: To evaluate Neosaxitoxin (NeoSTX) as a local anesthetic drug, for pain control during and after piglet castration. Study design: Prospective, randomized and double-blind study. Animals: 24 commercial hybrids, ...
    • Gonyautoxins: First evidence in pain management in total knee arthroplasty 
      Hinzpeter Cohen, Jaime Rodrigo; Barrientos Mendoza, Cristian Nelson; Zamorano Cadenas, Álvaro Igor; Martínez, Álvaro; Palet Bonell, Miguel Jaime Luis; Wulf Ibáñez, Rodrigo Alfonso; Barahona Vásquez, Maximiliano Andrés; Sepúlveda, Joaquín M.; Guerra, Matías; Bustamante, Tamara; Del Campo, Miguel; Tapia, Eric; Lagos, Néstor (Pergamon-Elsevier Science Ltd., 2016)
      Improvements in pain management techniques in the last decade have had a major impact on the practice of total knee arthroplasty (TKA). Gonyautoxin are phycotoxins, whose molecular mechanism of action is a reversible block ...
    • Hemocyanins as immunostimulants Hemocianinas, una herramienta inmunológica de la biomedicina actual 
      del Campo, Miguel; Arancibia, Sergio; Nova, Esteban; Salazar, Fabián; González, Andrea; Moltedo, Bruno; Ioannes, Pablo de; Ferreira, Jorge; Manubens, Augusto; Becker, María Inés (2011)
      Hemocyanins, the giant oxygen transporter glycoproteins of diverse mollusks, are xenogenic to the mammalian immune system and they display a remarkable immunogenicity. Therefore they are ideal non-specific immunostimulants ...
    • Immunodominant role of CCHA subunit of Concholepas hemocyanin is associated with unique biochemical properties 
      Becker, María Inés; Fuentes, Alejandra; Del Campo, Miguel; Manubens, Augusto; Nova, Esteban; Oliva, Harold; Faunes, Fernando; Valenzuela, María Antonieta; Campos Vallette, Marcelo; Aliaga, Alvaro E.; Ferreira, Jorge; Ioannes, Alfredo de; Ioannes, Pablo de; Moltedo, Br (2009)
      Hemocyanin, the oxygen transporter metallo-glycoprotein from mollusks, shows strong relationship between its notable structural features and intrinsic immunomodulatory effects. Here we investigated the individual contribution ...
    • Immunotherapeutic potential of mollusk hemocyanins in combination with human vaccine adjuvants in murine ... 
      Román, Juan José Mora; Del Campo, Miguel; Villar, Javiera; Paolini, Francesca; Curzio, Gianfranca; Venuti, Aldo; Jara, Lilian; Ferreira, Jorge; Murgas, Paola; Lladser, Alvaro; Manubens, Augusto; Becker, María Inés (Hindawi Limited, 2019)
      Mollusk hemocyanins have been used for decades in immunological and clinical applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the treatment of superficial bladder cancer, as ...
    • Nerve growth factor: a dual activator of noradrenergic and cholinergic systems of the rat ovary 
      Benítez, Agustín; Riquelme, Raúl; Campo, Miguel del; Araya, Camila; Lara, Hernán E. (Frontiers Media, 2021)
      The functioning of the ovary is influenced by the autonomic system (sympathetic and cholinergic intraovarian system) which contributes to the regulation of steroid secretion, follicular development, and ovulation. There ...
    • Okadaic acid toxin at sublethal dose produced cell proliferation in gastric and colon epithelial cell lines 
      Del Campo, Miguel; Toledo, Héctor; Lagos, Néstor (2013)
      The aim of this study was to analyze the effect of Okadaic Acid (OA) on the proliferation of gastric and colon epithelial cells, the main target tissues of the toxin. We hypothesized that OA, at sublethal doses, activates ...
    • Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate ... 
      del Campo, Miguel; Zhong, Ta- Ying; Tampe, Ricardo; García Nannig, Lorena; Lagos, Néstor (Elsevier Ltd, 2017)
      © 2016 Elsevier LtdOne of the proposed mechanisms to explain why Diarrhetic Shellfish Poison (DSP) toxins are tumor promoters is founded on the capacity of these toxins to increase TNF-α secretion. Although macrophages are ...
    • The oxygen-binding properties of hemocyanin from the mollusk Concholepas concholepas 
      González, Andrea; Nova, Esteban; Del Campo, Miguel; Manubens, Augusto; Ioannes, Alfredo de; Ferreira, Jorge; Becker, María Inés (Elsevier B.V., 2017)
      © 2017 Elsevier B.V. Hemocyanins have highly conserved copper-containing active sites that bind oxygen. However, structural differences among the hemocyanins of various mollusks may affect their physicochemical properties. ...