Browsing by Author "b94d9937-7ad9-4a57-adff-3398d0f60fb4"

Now showing items 1-14 of 14

    • A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization 
      Américo-Da-Silva, Luan; Diaz, Jheimmy; Bustamante, Mario; Mancilla, Georthan; Oyarzún, Ingrid; Verdejo, Hugo E.; Quiroga, Clara (FASEB, 2018)
      © FASEB. Bone integrity depends on a finely tuned balance between bone synthesis by osteoblasts and resorption by osteoclasts. The secretion capacity of mature osteoblasts requires strict control of proteostasis. Endoplasmic ...
    • Angiotensin II-regulated autophagy is required for vascular smooth muscle cell hypertrophy 
      Mondaca Ruff, David; Riquelme, Jaime A.; Quiroga, Clara; Norambuena Soto, Ignacio; Sanhueza Olivares, Fernanda; Villar-Fincheira, Paulina; Hernández-Díaz, Tomás; Cancino Arenas, Nicole; San Martin, Alejandra; García Nannig, Lorena; Lavandero González, Sergio; Chiong Lay, Mario (Frontiers Media S.A., 2019)
      Copyright © 2019 Mondaca-Ruff, Riquelme, Quiroga, Norambuena-Soto, Sanhueza-Olivares, Villar-Fincheira, Hernández-Díaz, Cancino-Arenas, San Martin, García, Lavandero and Chiong.Hypertension is a disease associated to ...
    • Apoptosis, necrosis and autophagy are influenced by metabolic energy sources in cultured rat spermatocytes 
      Bustamante Marín, Ximena; Quiroga, Clara; Lavandero González, Sergio; Reyes, Juan G.; Moreno, Ricardo D. (2012)
      Apoptosis, necrosis and autophagy are mechanistically related processes that control tissue homeostasis and cell survival. In the testis, germ cell death is important for controlling sperm output, but it is unknown whether ...
    • Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy 
      Pedrozo Cibils, Zully; Torrealba, Natalia; Fernández, Carolina; Gatica, Damián; Toro, Barbra; Quiroga, Clara; Rodríguez, Andrea E.; Sánchez, Gina; Gillette, Thomas G.; Hill, Joseph A.; Donoso Laurent, Paulina; Lavandero González, Sergio (the European Society of Cardiology, 2013)
      Aims Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins bearing the sequence KFERQ. These proteins are targeted by chaperones and delivered to lysosomes where ...
    • Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance 
      Troncoso, Rodrigo; Paredes, Felipe; Parra, Valentina; Gatica, Damián; Vásquez Trincado, César Alonso; Quiroga, Clara; Bravo Sagua, Roberto; López Crisosto, Camila; Rodriguez, Andrea E.; Oyarzún, Alejandra P.; Kroemer, Guido; Lavandero González, Sergio (Taylor and Francis Inc., 2014)
      Glucocorticoids, such as dexamethasone, enhance protein breakdown via ubiquitin-proteasome system. However, the role of autophagy in organelle and protein turnover in the glucocorticoid-dependent atrophy program remains ...
    • Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured ... 
      Marambio, Paola; Toro, Barbra; Sanhueza, Carlos; Troncoso, Rodrigo; Parra, Valentina; Verdejo, Hugo; García Nannig, Lorena; Quiroga, Clara; Munafo, Daniela; Díaz Elizondo, Jessica; Bravo Sagua, Roberto; González Burgos, María Julieta; Díaz Araya, Guillermo; Pedrozo Cibils, Zully; Chiong Lay, Mario; Co (2010)
      Aggresomes are dynamic structures formed when the ubiquitin-proteasome system is overwhelmed with aggregation-prone proteins. In this process, small protein aggregates are actively transported towards the microtubule-organizing ...
    • Herp depletion protects from protein aggregation by up-regulating autophagy 
      Quiroga, Clara; Gatica, Damián; Paredes, Felipe; Bravo, Roberto; Troncoso, Rodrigo; Pedrozo Cibils, Zully; Rodríguez, Andrea E.; Toro, Barbra; Chiong Lay, Mario; Vicencio Bustamante, José Manuel; Hetz Flores, Claudio; Lavandero González, Sergio (Elsevier, 2013)
      Herp is an endoplasmic reticulum (ER) stress inducible protein that participates in the ER-associated protein degradation (ERAD) pathway. However, the contribution of Herp to other protein degradation pathways like autophagy ...
    • Hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase ... 
      Eisner, Verónica; Quiroga, Clara; Criollo Céspedes, Alfredo; Eltit Ortega, José Miguel; Chiong Lay, Mario; Parra, Valentina; Hidalgo, Karla; Toro, Barbra; Díaz Araya, Guillermo; Lavandero González, Sergio (2006)
      NFκB is a participant in the process whereby cells adapt to stress. We have evaluated the activation of NFκB pathway by hyperosmotic stress in cultured cardiomyocytes and its role in the activation of caspase and cell ...
    • Hyperosmotic stress-dependent NFκB activation is regulated by reactive oxygen species and IGF-1 in cultured ... 
      Eisner, Verónica; Criollo Céspedes, Alfredo; Quiroga, Clara; Olea Azar, Claudio; Santibañez, Juan Francisco; Troncoso, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Foncea, Rocío; Lavandero González, Sergio (2006)
      We have recently shown that hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. It remains unexplored how NFκB is regulated in cultured rat ...
    • Mitochondria, myocardial remodeling, and cardiovascular disease 
      Verdejo, Hugo; Campo, Andrea del; Troncoso, Rodrigo; Gutiérrez, Tomás; Toro, Barbra; Quiroga, Clara; Pedrozo Cibils, Zully; Muñoz, Juan; García Nannig, Lorena; Castro, Pablo; Lavandero González, Sergio (2012)
      The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
    • Role of heterotrimeric G protein and calcium in cardiomyocyte hypertrophy induced by IGF-1 
      Carrasco Mujica, Loreto; Cea, Paola; Rocco, Paola; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Sotomayor Flores, Cristian Alejandro; Quiroga, Clara; Criollo Céspedes, Alfredo; Ibarra, Cristián; Chiong Lay, Mario; Lavandero González, Sergio (Wiley-Liss, 2014)
      In the heart, insulin‐like growth factor‐1 (IGF‐1) is a peptide with pro‐hypertrophic and anti‐apoptotic actions. The pro‐hypertrophic properties of IGF‐1 have been attributed to the extracellular regulated kinase (ERK) ...
    • Systemic oxidative stress and endothelial dysfunction is associated with an attenuated acute vascular ... 
      Gabrielli, Luigi; Castro, Pablo F.; Godoy, Ivan; Mellado, Rosemarie; Bourge, Robert C.; Alcaíno Gálvez, Hernán Alejandro; Chiong Lay, Mario; Greig, Douglas; Verdejo, Hugo; Navarro, Mario; Lopez, Rafael; Toro, Barbra; Quiroga, Clara; Díaz Araya, Guillermo; Lavandero González, Sergio; Garcia, Lo (2011)
      Background: Systemic endothelial dysfunction and increased oxidative stress have been observed in pulmonary arterial hypertension (PAH). We evaluate whether oxidative stress and endothelial dysfunction are associated with ...
    • The role of uric acid in heart failure Ácido úrico: Una molécula con acciones paradójicas en la insuficiencia ... 
      Alcaíno Gálvez, Hernán Alejandro; Greig, Douglas; Castro, Pablo; Verdejo, Hugo; Mellado, Rosemarie; García Nannig, Lorena; Díaz Araya, Guillermo; Quiroga, Clara; Chiong Lay, Mario; Lavandero González, Sergio (2011)
      Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart ...
    • Tumor necrosis factor-α activates nuclear factor-κB but does not regulate progesterone production in cultured ... 
      González Navarrete, Flor Cecilia; Eisner, Verónica; Morales, Priscilla; Castro, Olga; Pommer Téllez, Ricardo; Quiroga, Clara; Lavandero González, Sergio; Devoto, Luigi (2007)
      Background. The role of tumor necrosis factor-α (TNF-α) in granulosa luteal cell function and steroidogenesis is still controversial. Our aim was to examine the steroidogenic response, together with the simultaneous ...