Browsing by Author "beadd770-5f35-4d45-b6c3-7f3cc57a240b"
Now showing items 1-18 of 18
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Catalan-Figueroa, Johanna; Boisset, Constanza B.; Jara, Miguel O.; Flores, Mario E.; Moreno-Villoslada, Ignacio; Fiedler, Jenny L.; Morales, Javier O. (Elsevier B.V., 2018)© 2018 Elsevier B.V. Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In ...
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Montero, Guillermo; Günther Sapunar, Germán; Valdés Camus, Karina; Arriagada, Francisco; Morales, Javier O. (AOAC Int, 2018)In this work, we developed an HPLC method to simultaneously quantify and hence evaluate the stability, distribution, and antioxidant capacity of six isoflavones: genistein, genistin, daidzein, daidzin, glycitin, and biochanin ...
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Montero-Padilla, Soledad; Velaga, Sitaram; Morales, Javier O. (Springer New York LLC, 2017)© 2016, American Association of Pharmaceutical Scientists. The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution differs from that ...
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Morales, Javier O.; Fathe, Kristin R.; Brunaugh, Ashlee; Ferrati, Silvia; Li, Song; Montenegro-Nicolini, Miguel; Mousavikhamene, Zeynab; McConville, Jason T.; Prausnitz, Mark R.; Smyth, Hugh D.C. (Springer New York LLC, 2017)© 2017, American Association of Pharmaceutical Scientists. Biologic products are large molecules such as proteins, peptides, nucleic acids, etc., which have already produced many new drugs for clinical use in the last ...
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Gamboa, Alexander; Schuessler, Nina; Soto Bustamante, Eduardo; Romero Hasler, Patricio; Meinel, Lorenz; Morales, Javier O. (Elsevier, 2020)New therapeutics such as antisense oligonucleotides, small interfering RNA and peptide-drug conjugates are taking great relevance in the pharmaceutical industry due to their specificity of action and their improved safety ...
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Sepúlveda Rivas, Sabrina; Fritz, Hans F.; Valenzuela, Camila; Santiviago, Carlos A.; Morales, Javier O. (MDPI AG, 2019)The number of biologic drugs has increased in the pharmaceutical industry due to their high therapeutic efficacy and selectivity. As such, safe and biocompatible delivery systems to improve their stability and efficacy are ...
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Vuddanda, Parameswara Rao; Montenegro-Nicolini, Miguel; Morales, Javier O.; Velaga, Sitaram (Elsevier B.V., 2017)© 2016 Elsevier B.V.The effect of different plasticizers (glycerol, vitamin E TPGS and triacetin) and their concentrations on the physico-mechanical properties of pullulan based oral films was studied. A full factorial ...
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Morales, Javier O.; Huang, Siyuan; Williams, Robert O.; McConville, Jason T. (Elsevier, 2014)The goal of this investigation was to develop films containing insulin-coated nanoparticles and evaluate their performance in vitro as potential peptide delivery systems. To incorporate insulin into the films, a new ...
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Morales, Javier (Springer New York LLC, 2017)
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Montenegro-Nicolini, Miguel; Miranda, Víctor; Morales, Javier O. (Springer New York LLC, 2017)© 2016, American Association of Pharmaceutical Scientists. Peptides and proteins represent a promissory group of molecules used by the pharmaceutical industry for drug therapy with great potential for development. However, ...
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Morales, Javier; Valdés, Karina; Morales, Javier; Oyarzún Ampuero, Felipe (Future Medicine Ltd., 2015)Retinoids are lipophilic compounds that are highly used in cosmetics/therapeutics for skin disorders. Conventional formulations are limited by poor water solubility, high chemical/photochemical instability and the irritation ...
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Bejarano, Julian; Navarro Márquez, Mario F.; Morales Zavala, Francisco; Morales, Javier O.; García Carvajal, Ivonne; Araya Fuentes, Eyleen; Flores, Yvo; Verdejo, Hugo E.; Castro, Pablo F.; Lavandero González, Sergio; Kogan Bocian, Marcelo (Ivyspring International Publisher, 2018)© Ivyspring International Publisher. Cardiovascular diseases are the leading cause of death worldwide. Despite preventive efforts, early detection of atherosclerosis, the common pathophysiological mechanism underlying ...
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Morales, Javier O.; McConville, Jason T. (Informa Healthcare, 2014)For years now, the delivery of small molecules through the buccal mucosal route has been described in the literature, but it has only been over the past decade that investigations into macromolecule delivery via the buccal ...
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Montenegro-Nicolini, Miguel; Morales, Javier O. (Springer New York LLC, 2017)© 2016, American Association of Pharmaceutical Scientists.The main route of administration for drug products is the oral route, yet biologics are initially developed as injectables due to their limited stability through ...
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Valdés Camus, Karina; Morales, Javier; Rodríguez, Lennin; Günther Sapunar, Germán (Future Medicine Ltd, 2016-12)Ursolic, oleanolic and betulinic acids are representative pentacyclic triterpenoids found in various plants and fruits. Despite having marked antitumor potentials, the very poor water solubility of these triterpenes hinders ...
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Fritz, Hans; Ortiz, Andrea; Velaga, Sitaram; Morales, Javier (Springer Verlag, 2018)High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics ...
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Cumsille, Sebastian; Morales, Javier O.; Sandoval Altamirano, Catalina; Guenther, Germán; Vega, Andrés; Pizarro, Nancy (Elsevier Science SA, 2018)Lercanidipine (LERCA) is a third generation antihypertensive drug belonging to the 1,4-dihydropyridine's family, which has been reported to induce photoallergic and/or phototoxic effects in patients with long term treatment. ...
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Montenegro-Nicolini, Miguel; Reyes, Patricio E.; Jara, Miguel O.; Vuddanda, Parameswara R.; Neira-Carrillo, Andrónico; Butto, Nicole; Velaga, Sitaram; Morales, Javier O. (Springer New York LLC, 2018)© 2018 American Association of Pharmaceutical Scientists The buccal mucosa appears as a promissory route for biologic drug administration, and pharmaceutical films are flexible dosage forms that can be used in the buccal ...