Now showing items 1-16 of 16

    • Regan, Jennifer C.; Concha, Miguel L.; Roussigne, Myriam; Russell, Claire; Wilson, Stephen W. (2009)
      Neuroanatomical and functional asymmetries are universal features of the vertebrate CNS, but how asymmetry is generated is unknown. Here we show that zebrafish fgf8 mutants do not elaborate forebrain asymmetries, demonstrated ...
    • Reig, Germán; Pulgar, Eduardo; Concha, Miguel L. (Company of Biologists Ltd, 2014)
      Cell migration is a fundamental process that occurs during embryo development. Classic studies using in vitro culture systems have been instrumental in dissecting the principles of cell motility and highlighting how cells ...
    • Borgonovo, Janina; Allende-Castro, Camilo; Laliena, Almudena; Guerrero, Néstor; Silva, Hernán; Concha, Miguel L. (Elsevier Ltd, 2017)
      © 2016 Elsevier Ltd Although Parkinson's Disease (PD) is mostly considered a motor disorder, it can present at early stages as a non-motor pathology. Among the non-motor clinical manifestations, depression shows a high ...
    • Kudoh, Tetsuhiro; Concha, Miguel L.; Houart, Corinne; Dawid, Igor B.; Wilson, Stephen W. (2004)
      Studies in fish and amphibia have shown that graded Bmp signalling activity regulates dorsal-to-ventral (DV) patterning of the gastrula embryo. In the ectoderm, it is thought that high levels of Bmp activity promote epidermal ...
    • Aboitiz, Francisco; Concha, Miguel L.; González Billault, Christian; Mpodozis Marín, Jorge (Frontiers Media SA., 2018-06-29)
    • Concha, Miguel L.; Bianco, Isaac H.; Wilson, Stephen W. (2012)
      Genetic and environmental factors control morphological and functional differences between the two sides of the nervous system. Neural asymmetries are proposed to have important roles in circuit physiology, cognition and ...
    • Villalón, Aldo; Sepulveda, Mauricio; Guerrero, Néstor; Meynard, Margarita M.; Palma, Karina; Concha, Miguel L. (2012)
      The vertebrate habenulae (Hb) is an evolutionary conserved dorsal diencephalic nuclear complex that relays information from limbic and striatal forebrain regions to the ventral midbrain. One key feature of this bilateral ...
    • Concha, Miguel L. (2005)
      Vallortigara & Rogers (V & R) propose a fundamental role of the environment in determining population-level lateralisation and suggest that genes play no primary function in this phenomenon. Here I argue that genes involved ...
    • Reig, German; Concha, Miguel L. (2012)
      SUMMARY: In diploid organisms, autosomal genes are composed of two copies, or alleles, inherited from both parents at fertilization. For the vast majority of autosomal genes, expression occurs from both alleles simultaneously. ...
    • Signore, Iskra A.; Concha, Miguel L. (John Wiley and Sons Inc., 2017)
      © 2016 Wiley Periodicals, Inc. Heterochrony is one proposed mechanism to explain how morphological variation and novelty arise during evolution. To experimentally approach heterochrony in a comprehensive manner, we must ...
    • Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, René L.; Rodríguez, Diego A.; Rivera, Claudia A.; Court, Felipe A.; Couve Correa, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic Maurer, Álvaro; González Billault, Christian; Hetz Flores, Claudio (Nature, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
    • Díaz, Eugenia; Barra Bravo, Daniela Fernanda; Rojas, Ximena; Concha, Miguel L. (2011)
      The habenular complex (HbCpx) is a phylogenetically conserved brain structure located in the epithalamus of vertebrates. Despite its fundamental role in decision-making processes and the proposed link between habenular ...
    • Tada, Masazumi; Concha, Miguel L.; Heisenberg, Carl Philipp (Elsevier Ltd, 2002)
      Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt ...
    • Oteiza, Pablo; Köppen, Mathias; Krieg, Michael; Pulgar, Eduardo; Farias, Cecilia; Melo, Cristina; Preibisch, Stephan; Müller, Daniel; Tada, Masazumi; Hartel, Steffen; Heisenberg, Carl-Philipp; Concha, Miguel L. (Company of Biologists Ltd, 2010)
      Organ formation requires the precise assembly of progenitor cells into a functional multicellular structure. Mechanical forces probably participate in this process but how they influence organ morphogenesis is still unclear. ...
    • Concha, Miguel L. (2004)
      Lateralisation is an attractive and intriguing feature of the vertebrate CNS studied for decades in the different disciplines of the neurosciences. Due to the complexity of the phenomena and intrinsic limitations of the ...
    • Stanic, Karen; Reig, German; Wichmann, Ignacio A.; Opazo, Juan C.; Owen, Gareth I.; Corvalán, Alejandro H.; Concha, Miguel L.; Amigo, Julio D. (Nature Publishing Group, 2019)
      The Reprimo gene family comprises a group of single-exon genes for which their physiological function remains poorly understood. Heretofore, mammalian Reprimo (RPRM) has been described as a putative p53-dependent tumor ...