Browsing by Author "c2620e1b-7742-40e1-ba4f-a65a489540aa"

Now showing items 1-4 of 4

    • Dual IRE1 RNase functions dictate glioblastoma development 
      Lhomond, Stephanie; Avril, Tony; Dejeans, Nicolas; Hetz Flores, Claudio (Wiley, 2018)
      Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...
    • Emerging roles of the endoplasmic reticulum associated unfolded protein response in cancer cell migration ... 
      Limia, Celia Maria; Sauzay, Chloé; Urra, Hery; Hetz Flores, Claudio; Chevet, Eric; Avril, Tony (MDPI AG, 2019)
      Endoplasmic reticulum (ER) proteostasis is often altered in tumor cells due to intrinsic (oncogene expression, aneuploidy) and extrinsic (environmental) challenges. ER stress triggers the activation of an adaptive response ...
    • Endoplasmic reticulum proteostasis in glioblastoma - From molecular mechanisms to therapeutic perspectives 
      Obacz, Joanna; Avril, Tony; Le Reste, Pierre Jean; Urra, Hery; Quillien, Véronique; Hetz Flores, Claudio; Chevet, Eric (American Association for the Advancement of Science, 2017)
      © 2017 The Authors, some rights reserved.Cellular stress induced by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) is a central feature of secretory cells and is observed in many tissues in various ...
    • Endoplasmic Reticulum Stress and the Hallmarks of Cancer 
      Urra, Hery; Dufey, Estefanie; Avril, Tony; Chevet, Eric; Hetz Flores, Claudio (Cell Press, 2016)
      © 2016 Elsevier Inc. Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis, thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an adaptive mechanism ...