Now showing items 1-20 of 26

    • Association of Parkinson disease to PARK16 in a Chilean sample 

      Ramírez, Alfredo; Ziegler, Andreas; Winkler, Susen; Kottwitz, Jan; Giesen, Roland; Díaz Grez, Fernando; Miranda, Marcelo; Venegas Francke, Pablo; Trujillo Godoy, Osvaldo; Avello, Rodrigo; Behrens Pellegrino, María Isabel; Klein, Christine; Segura Aguilar, Juan; Lohmann, Katja (Elsevier, 2011-01)
    • Batrachotoxin-modified sodium channels from squid optic nerve in planar bilayers: Ion conduction and gating properties 

      Behrens Pellegrino, María Isabel; Oberhauser, Andres; Bezanilla, Francisco; Latorre, Ramón (1989)
      Squid optic nerve sodium channels were characterized in planar bilayers in the presence of batrachotoxin (BTX). The channel exhibits a conductance of 20 pS in symmetrical 200 mM NaCI and behaves as a sodium electrode. The ...
    • Cancer imprints an increased PARP-1 and p53-Dependent resistance to oxidative stress on lymphocytes of patients that later develop Alzheimer's disease 

      Salech, Felipe; Ponce, Daniela P.; San Martín, Carol D.; Rogers Castillo, Nicole; Henríquez, M.; Behrens Pellegrino, María Isabel (Frontiers Media SA, 2018)
      We have proposed that a common biological mechanism deregulated in opposite directions might explain the inverse epidemiological association observed between Alzheimer's disease (AD) and cancer. Accordingly, we showed that ...
    • Cancer linked to Alzheimer disease but not vascular dementia 

      Roe, Catherine M.; Fitzpatrick, A. L.; Xiong, C.; Sieh, W.; Kuller, L.; Miller, J. P.; Williams, M. M.; Kopan, R.; Behrens Pellegrino, María Isabel; Morris, J. C. (2010-01-12)
      Objective: To investigate whether cancer is associated with Alzheimer disease (AD) and vascular dementia (VaD). Methods: Cox proportional hazards models were used to test associations between prevalent dementia and risk ...
    • Cien años de la enfermedad de Alzheimer. La inmunoterapia ¿una esperanza? 

      Behrens Pellegrino, María Isabel; Vergara E., Fernando (2007)
      In 1906 Alois Alzheimer, described the cerebral lesions characteristic of the disorder that received his name: senile plaques and neurofibrillary tangles. Alzheimer’s disease (AD) is now, 100 years after, the most prevalent ...
    • Clinical Spectrum of Kufor-Rakeb Syndrome in the Chilean Kindred with ATP13A2 Mutations 

      Behrens Pellegrino, María Isabel; Brüggemann, Norbert; Chana, Pedro; Venegas Francke, Pablo; Kägi, Marianne; Parrao, Teresa; Orellana, Patricia; Garrido, Cristián; Rojas, Cecilia V.; Hauke, Jan; Hahnen, Eric; González Victoriano, Rafael; Seleme Herrero, Eduardo; Fernández, Verónica; Schmidt, Alexander; Binkofski, Ferdinand; Kömpf, Detlef; Kubisch, Christian; Hagenah, Johann; Klein, Christine; Ramírez, Alfredo (2010)
      Abstract: We report the clinical features of the original Chilean family with Kufor-Rakeb syndrome (KRS) that led to the discovery of the ATP13A2 gene at the PARK9 locus. KRS is a rare juvenile-onset autosomal recessive ...
    • Colchicine alters apamin receptors, electrical activity, and skeletal muscle relaxation 

      Vergara, Cecilia; Ramirez, Beatriz; Behrens Pellegrino, María Isabel (1993)
      A low conductance calcium‐activated K+ channel is thought to regulate the rate of firing of several excitable cells. In skeletal muscle the expression of this channel is under nerve control. Previously, we reported that ...
    • Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex 

      Bull Simpfendorfer, Ricardo; Finkelstein, José Pablo; Humeres, Alexis; Behrens Pellegrino, María Isabel; Hidalgo Tapia, María Cecilia (AMER PHYSIOLOGICAL SOC, 2007-07)
      Despite their relevance for neuronal Ca2+-induced Ca2+ release (CICR), activation by Ca2+ of ryanodine receptor (RyR) channels of brain endoplasmic reticulum at the [ ATP], [Mg2+], and redox conditions present in neurons ...
    • Frizzled-1 receptor regulates adult hippocampal neurogenesis 

      Mardones, Muriel D.; Andaur, Gabriela A.; Varas Godoy, Manuel; Henriquez, Jenny F.; Salech, Felipe; Behrens Pellegrino, María Isabel; Couve Correa, Andrés; Inestrosa, Nibaldo C.; Varela Nallar, Lorena (BioMed Central Ltd., 2016)
      © 2016 Mardones et al. Background: In the adult hippocampus new neurons are continuously generated from neural stem cells (NSCs) present at the subgranular zone of the dentate gyrus. This process is controlled by Wnt ...
    • HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin 

      Mukherjee, Odity; Pastor, Pau; Cairns, Nigel J.; Chakraverty, Sumi; Kauwe, John S. K.; Shears, Shantia; Behrens Pellegrino, María Isabel; Budde, John; Hinrichs, Anthony L.; Norton, Joanne; Levitch, Denise; Taylor-Reinwald, Lisa; Gitcho, Michael; Tu, P.-H.; Grinberg, Lea Tenenholz; Liscic, Rajka M.; Armendariz, Javier; Morris, John C.; Goate, Alison M. (WILEY-LISS, DIV JOHN WILEY & SONS, 2006-09)
      Objective: Familial autosomal dominant frontotemporal dementia with ubiquitin-positive, tau-negative inclusions in the brain linked to 17q21-22 recently has been reported to carry null mutations in the progranulin gene ...
    • Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase 

      Ramírez, Alfredo; Heimbach, André; Gründemann, Jan; Stiller, Barbara; Hampshire, Dan; Cid, L. Pablo; Goebel, Ingrid; Mubaidin, Ammar F.; Wriekat, Abdul-Latif; Roeper, Jochen; Al-Din, Amir; Hillmer, Axel M.; Karsak, Meliha; Liss, Birgit; Woods, C. Geoffrey; Behrens Pellegrino, María Isabel; Kubisch, Christian (NATURE PUBLISHING GROUP, 2006-10)
      Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and disabling disorders(1). Although the complex molecular pathophysiology ...
    • Inverse Association between Cancer and Dementia of the Alzheimer’s Type 

      Behrens Pellegrino, María Isabel; Roe, Catherine M.; Morris, John C. (Nova Science Publishers, Inc., 2008)
      With increasing life expectancy there is also a concomitant increase in the prevalence of agerelated disorders, including neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various cancers. ...
    • Ischemia Enhances Activation by Ca2+ and Redox Modification of Ryanodine Receptor Channels from Rat Brain Cortex 

      Bull Simpfendorfer, Ricardo; Finkelstein, José Pablo; Gálvez, Jorge; Sánchez, Gina; Donoso Laurent, Paulina; Behrens Pellegrino, María Isabel; Hidalgo Tapia, María Cecilia (2008)
      Cerebral ischemia stimulates Ca2+influx and thus increases neuronal intracellular free [Ca2+. Using a rat model of cerebral ischemia without recirculation, we tested whether ischemia enhances the activation by Ca2+ of ...
    • Memoria, fluidez y orientación: prueba de cribado de deterioro cognitivo en 5 minutos 

      Delgado Derio, C.; Guerrero Bonnet, S.; Troncoso Ponce, M.; Araneda Yáñez, A.; Slachevsky Chonchol, Andrea; Behrens Pellegrino, María Isabel (Elsevier, 2013)
      Antecedentes: En los próximos 20 a˜nos se duplicará la cantidad de personas con deteriorocognitivo (DC) apremiando su pronta detección.Objetivos: Validar una prueba de cribado de DC aplicable en < de 5 min.Métodos: Adultos ...
    • Mild cognitive impairment: Follow-up of ten patients Deterioro cognitivo leve: Seguimiento de 10 casos 

      Donoso, Archibaldo; Behrens Pellegrino, María Isabel; Venegas, Pablo (2003)
      36 patients who presented with mild cognitive impairment (MCI) (memory loss and a Minimental test de Folstein (MMT) of 25-30) had previously been followed up for 31 months: 15 developed Alzheimer dementia, 11 got better ...
    • Neural control of the expression of a Ca2+-activated K+ channel involved in the induction of myotonic-like characteristics 

      Ramírez, Beatriz U.; Behrens Pellegrino, María Isabel; Vergara, Cecilia (Kluwer Academic/Plenum Publishers, 1996)
      1. Expression of the apamin-sensitive K+ channel (SK+) in rat skeletal muscle is neurally regulated. The regulatory effect of the nerve over the expression of some muscle ion channels has been attributed to the electrical ...
    • Neuropathologic Heterogeneity in HDDD1: A Familial Frontotemporal Lobar Degeneration With Ubiquitin-positive Inclusions and Progranulin Mutation 

      Behrens Pellegrino, María Isabel; Mukherjee, Odity; Tu, Pang-hsien; Liscic, Rajka M.; Grinberg, Lea Tenenholz; Carter, Deborah; Paulsmeyer, Katherine; Taylor-Reinwald, Lisa; Gitcho, Michael; Norton, Joanne; Chakraverty, Sumi; Goate, Alison M.; Morris, John C.; Cairns, Nigel J. (Lippincott Williams & Wilkins, 2007-03)
      Hereditary dysphasic disinhibition dementia (HDDD) describes a familial disorder characterized by personality changes, and language and memory deficits. The neuropathology includes frontotemporal lobar atrophy, neuronal ...
    • On the role of mining exposure in epigenetic effects in parkinson’s disease 

      Castillo, Sebastián; Muñoz, Patricia; Behrens Pellegrino, María Isabel; Díaz Grez, Fernando; Segura Aguilar, Juan (Springer, 2017)
      To explore the possible influence of heavy metal mining on incidence of Parkinson’s disease (PD), global DNA methylation was assessed in blood samples from a population of PD patients (n = 45) and control subjects (n = ...
    • PARP-1 and p53 regulate the increased susceptibility to oxidative death of lymphocytes from MCI and AD patients 

      Salech Morales, Felipe; Ponce, Daniela P.; San Martín Rovirosa, Carol; Rogers Castillo, Nicole; Chacón, Carlos; Henriquez Luna, Mauricio; Behrens Pellegrino, María Isabel (Frontiers media SA, 2017)
      Mild cognitive impairment (MCI) is a clinically detectable initial stage of cognitive deterioration with a high conversion rate to dementia. There is increasing evidence that some of the cerebral alterations present in ...
    • Possible role of apamin‐sensitive K+ channels in myotonic dystrophy 

      Behrens Pellegrino, María Isabel; Jalil, Patricio; Serani, Alejandro; Vergara, Fernando; Álvarez Araya, Osvaldo (1994)
      Myotonic muscular dystrophy is a genetic disease characterized mainly by muscle atrophy and myotonia, a repetitive electrical activity of muscle. In the present study, the possible role of apamin‐sensitive K+ channels in ...