Browsing by Author "c46fe2e3-9caf-4b32-a3d8-0a6dae084751"

Now showing items 1-5 of 5

    • Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1 alpha S-Nitrosylation and Transcriptional ... 
      Sanhueza, Carlos; Castillo Bennett, Jimena; Valenzuela Valderrama, Manuel; Contreras, Pamela; Lobos González, Lorena; Campos, América; Wehinger, Sergio; Lladser, Álvaro; Kiessling, Rolf; Leyton Campos, Lisette; Quest, Andrew F. G. (MDPI, 2020)
      Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the ...
    • Helicobacter pylori and gastric cancer: adaptive cellular mechanisms involved in disease progression 
      Díaz, Paula; Valenzuela Valderrama, Manuel; Bravo, Jimena; Quest, Andrew F. G. (Frontiers Media SA, 2018)
      Helicobacter pylori (H. pylori) infection is the major risk factor associated with the development of gastric cancer. The transition from normal mucosa to non-atrophic gastritis, triggered primarily by H. pylori infection, ...
    • Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells 
      Garrido Palma, Maritza; Salvatierra, Renato; Valenzuela Valderrama, Manuel; Vallejos, Christopher; Bruneau, Nicole; Hernández, Andrea; Vega Blanco, María Margarita; Selman Abuchaibe, Alberto; Geoffery Quest, Andrew; Romero Osses, Carmen (MDPI, 2020)
      Epithelial ovarian cancer (EOC) is a lethal gynaecological neoplasm characterized by rapid growth and angiogenesis. Nerve growth factor (NGF) and its high affinity receptor tropomyosin receptor kinase A (TRKA) contribute ...
    • NGF/TRKA Decrease miR-145-5p Levels in Epithelial Ovarian Cancer Cells 
      Garrido Palma, Maritza; Torres, Ignacio; Ávila, Alba; Chnaiderman Figueroa, Jonas; Valenzuela Valderrama, Manuel; Aramburo, José; Oróstica, Lorena; Durán Jara, Eduardo; Lobos González, Lorena; Romero Osses, Carmen (MDPI, 2020)
      Nerve Growth Factor (NGF) and its high-affinity receptor tropomyosin receptor kinase A (TRKA) increase their expression during the progression of epithelial ovarian cancer (EOC), promoting cell proliferation and angiogenesis ...
    • The 5’ untranslated region of the anti-apoptotic protein Survivin contains an inhibitory upstream AUG codon 
      Palavecino, Christian E.; Carrasco Véliz, Nicolás; Quest, Andrew F.G.; Garrido Palma, Maritza P.; Valenzuela Valderrama, Manuel (Elsevier, 2020)
      Survivin (BIRC5) is an anti-apoptotic protein that is important in cancer. Mechanisms responsible for controlling Survivin levels in cells include transcriptional regulation and modulation of protein stability via ...