Now showing items 1-2 of 2

    • Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly 

      Gutiérrez, Eunices; Benites, Julio; Valderrama, Jaime; Buc Calderón, Pedro; Verrax, Julien; Nova Martínez, Esteban; Villanelo Lizana, Felipe; Maturana Middleton, Daniel; Escobar, Cristian; Lagos Mónaco, Rosalba; Monasterio Opazo, Octavio (Elsevier, 2015)
      Dihydroxynaphthyl aryl ketones 1e5 have been evaluated for their abilities to inhibit microtubule assembly and the binding to tubulin. Compounds 3, 4 and 5 displayed competitive inhibition against colchicine binding, and ...
    • Conformational dynamics of substituted N-acetyl-N-phenylbenzylamines. 1H-DNMR and AM1-MO study 

      Weiss López, Boris; Saitz Barría, Claudio; Pessoa Mahana, Hernán; Valderrama, Jaime; Araya Maturana, Ramiro (2001)
      Activation parameters for the rotation around the methylene-nitrogen single bond found in a series of four 2,2'-disubstituted N-acetyl-N-phenylbenzylamines, dissolved in DMSO-d6, were measured employing the temperature ...