Browsing by Author "c61ce674-cf29-4153-92d1-c3bfc6f6a719"

Now showing items 1-13 of 13

    • Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1 alpha S-Nitrosylation and Transcriptional ... 
      Sanhueza, Carlos; Castillo Bennett, Jimena; Valenzuela Valderrama, Manuel; Contreras, Pamela; Lobos González, Lorena; Campos, América; Wehinger, Sergio; Lladser, Álvaro; Kiessling, Rolf; Leyton Campos, Lisette; Quest, Andrew F. G. (MDPI, 2020)
      Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the ...
    • Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast ... 
      Lobos González, Lorena; Bustos, Rocío; Campos, América; Silva, Valeria; Silva, Verónica; Jeldes, Emanuel; Salomón, Carlos; Varas Godoy, Manuel; Cáceres Verschae, Albano; Durán, Eduardo; Vera, Tamara; Ezquer, Fernando; Ezquer, Marcelo; Burzio, Verónica A.; Villegas, Jaime (Nature, 2020)
      During intercellular communication, cells release extracellular vesicles such as exosomes, which contain proteins, ncRNAs and mRNAs that can influence proliferation and/or trigger apoptosis in recipient cells, and have ...
    • Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma ... 
      Ortiz, Rina; Díaz Jara, Jorge; Díaz, Natalia; Lobos González, Lorena; Cárdenas, Areli; Contreras, Pamela; Díaz, María Inés; Otte, Ellen; Cooper- White, Justin; Torres Gómez, Vicente; Leyton Campos, Lisette; Quest, Andrew F. G. (Impact Journals LLC, 2016)
      Caveolin-1 (CAV1) is a scaffolding protein that plays a dual role in cancer. In advanced stages of this disease, CAV1 expression in tumor cells is associated with enhanced metastatic potential, while, at earlier stages, ...
    • Gold nanoparticle based double‑labeling of melanoma extracellular vesicles to determine the specificity of ... 
      Lara, Pablo; Palma Florez, Sujey; Salas Huenuleo, Edison; Polakovicova, Iva; Guerrero, Simón; Lobos González, Lorena; Campos, América; Muñoz, Luis; Jorquera Cordero, Carla; Varas Godoy, Manuel; Cancino, Jorge; Arias, Eloísa; Villegas, Jaime; Cruz, Luis J.; Albericio, Fernando; Araya, Eyleen; Corvalán, Alejandro H.; Quest, Andrew F. G.; Kogan Bocian, Marcelo (BMC, 2020)
      Background Extracellular vesicles (EVs) have shown great potential for targeted therapy, as they have a natural ability to pass through biological barriers and, depending on their origin, can preferentially accumulate at ...
    • Gold nanoparticles as tracking devices to shed light on the role of caveolin-1 in early stages of melanoma ... 
      Guerrero, Simón; Díaz García, Víctor; Contreras-Orellana, Pamela; Muñoz Lara, Pablo; Palma, Sujey; Guzmán, Fanny; Lobos González, Lorena; Cárdenas, Areli; Rojas Silva, Ximena; Muñoz, Luis; Leyton Campos, Lisette; Kogan Bocian, Marcelo; Quest, Andrew F. G. (Future Medicine, 2018-06)
      Aim: To track early events during lung metastasis, we labeled cells expressing (B16F10(CAV1)) or lacking CAV1 (B16F10(mock)) with gold nanoparticles conjugated to the peptide TAT (AuNPs-PEG-TAT). Methods: B16F10 expressing ...
    • Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat 
      Sapag Muñoz de la Peña, Amalia; Irarrázaval Aguilera, Thergiorg; Lobos González, Lorena; Muñoz Brauning, Carlos; Quintanilla González, María Elena; Tampier de Jong, Lutske (Nature Publishing Group, 2016)
      Ribozyme genes were designed to reduce voluntary alcohol drinking in a rat model of alcohol dependence. Acetaldehyde generated from alcohol in the liver is metabolized by the mitochondrial aldehyde dehydrogenase (ALDH2) ...
    • Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration ... 
      De Gregorio, Cristián; Contador, David; Díaz, Diego; Cárcamo, Constanza; Santapau, Daniela; Lobos González, Lorena; Acosta, Cristián; Campero Soffia, Mario; Carpio, Daniel; Gabriele, Caterina; Gaspari, Marco; Aliaga Tobar, Víctor; Maracaja Coutinho, Vinicius; Ezquer, Marcelo; Ezquer, Fernando (BMC, 2020)
      Background Diabetic polyneuropathy (DPN) is the most common and early developing complication of diabetes mellitus, and the key contributor for foot ulcers development, with no specific therapies available. Different studies ...
    • MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer 
      Sandoval Borquez, Alejandra; Polakovicova, Iva; Carrasco Véliz, Nicolás; Lobos González, Lorena; Riquelme, Ismael; Carrasco Aviño, Gonzalo; Bizama, Carolina; Norero, Enrique; Owen, Gareth I.; Roa, Juan; Corvalán, Alejandro H. (Biomed Central Ltd., 2017)
      Background: Multiple aberrant microRNA expression has been reported in gastric cancer. Among them, microRNA-335-5p (miR-335), a microRNA regulated by DNA methylation, has been reported to possess both tumor suppressor and ...
    • NGF/TRKA Decrease miR-145-5p Levels in Epithelial Ovarian Cancer Cells 
      Garrido Palma, Maritza; Torres, Ignacio; Ávila, Alba; Chnaiderman Figueroa, Jonas; Valenzuela Valderrama, Manuel; Aramburo, José; Oróstica, Lorena; Durán Jara, Eduardo; Lobos González, Lorena; Romero Osses, Carmen (MDPI, 2020)
      Nerve Growth Factor (NGF) and its high-affinity receptor tropomyosin receptor kinase A (TRKA) increase their expression during the progression of epithelial ovarian cancer (EOC), promoting cell proliferation and angiogenesis ...
    • Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells 
      Ortiz, Rina; Díaz, Jorge; Díaz Valdivia, Natalia; Martínez Meza, Samuel; Simón, Layla; Contreras Orellana, Pamela; Lobos González, Lorena; Guerrero, Simón; Leyton Campos, Lisette; Quest, Andrew F. G. (Elsevier, 2020)
      In advanced stages of cancer disease, caveolin-1 (CAV1) expression increases and correlates with increased migratory and invasive capacity of the respective tumor cells. Previous findings from our laboratory revealed that ...
    • Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through ... 
      Lobos González, Lorena; Silva, Verónica; Araya, Mariela; Restovic, Franko; Echeñique, Javiera; Oliveira Cruz, Luciana; Fitzpatrick, Christopher; Briones, Macarena; Villegas, Jaime; Villota, Claudio; Vidaurre, Soledad; Borgna, Vincenzo; Socias, Miguel; Valenzuela, Sebastián; López, Constanza; Socias, Teresa; Varas, Manuel; Díaz, Jorge; Burzio, Luis O.; Burzio, Verónica A. (Impact Journals, 2016)
      We reported that knockdown of the antisense noncoding mitochondrial RNAs (ASncmtRNAs) induces apoptotic death of several human tumor cell lines, but not normal cells, suggesting this approach for selective therapy against ...
    • Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor ... 
      Borgna Christie, Vincenzo; Lobos González, Lorena; Guevara, Francisca; Landerer, Eduardo; Bendek, Maximiliano; Ávila, Rodolfo; Silva, Verónica; Villota, Claudio; Araya, Mariela; Rivas, Alexis; López, Constanza; Socias, Teresa; Castillo, Jorge; Alarcón Navarrete, Luis; Burzio, Luis O.; Burzio, Verónica A.; Villegas, Jaime (Ivyspring International Publisher, 2020)
      Knockdown of the antisense noncoding mitochondrial RNAs (ASncmtRNAs) induces apoptotic death of several human tumor cell lines, but not normal cells, supporting a selective therapy against different types of cancer. In ...
    • The non-receptor tyrosine phosphatase type 14 blocks caveolin-1- enhanced cancer cell metastasis 
      Díaz Valdivia, Natalia; Díaz, Jorge; Contreras, Pamela; Campos, América; Rojas Celis, Victoria; Burgos Ravanal, Renato; Lobos González, Lorena; Torres Gómez, Vicente; Pérez, Viviana I.; Frei, Balz; Leyton Campos, Lisette; Quest, Andrew F. G. (Nature, 2020)
      Caveolin-1 (CAV1) enhanced migration, invasion, and metastasis of cancer cells is inhibited by co-expression of the glycoprotein E-cadherin. Although the two proteins form a multiprotein complex that includes beta-catenin, ...