Browsing by Author "c6fa5e77-fc74-4548-94af-eeae970eb11f"

Now showing items 1-18 of 18

    • A Novel ER Stress-Independent Function of the UPR in Angiogenesis 
      Urra, Hery; Hetz Flores, Claudio (Cell Press, 2014)
      Tumors rely on the unfolded protein response (UPR) and angiogenesis to survive the metabolic stress of hypoxia. Karali et al. (2014) revealed that VEGF signaling engages UPR sensors in an unconventional manner that is ...
    • BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded ... 
      Rodriguez, Diego A.; Zamorano, Sebastian; Lisbona, Fernanda; Rojas Rivera, Diego; Urra, Hery; Cubillos-Ruiz, Juan R.; Armisen Yáñez, Ricardo; Henriquez, Daniel R.; Cheng, Emily; Letek, Michal; Vaisar, Tomas; Irrazabal, Thergiory; González Billault, Christian; Letai, Antho (2012)
      Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor inositol-requiring enzyme 1α(IRE1α), which functions as an endoribonuclease that splices the ...
    • Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response 
      Díaz, María I.; Díaz, Paula; Castillo Bennett, Jimena; Urra, Hery; Ortiz, Rina; Contreras Orellana, Pamela; Hetz Flores, Claudio; Quest, Andrew F. G. (Springer Nature, 2020)
      Caveolin-1 (CAV1), is a broadly expressed, membrane-associated scaffolding protein that acts both, as a tumor suppressor and a promoter of metastasis, depending on the type of cancer and stage. CAV1 is downregulated in ...
    • Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein ... 
      Groenendyk, Jody; Paskevicius, Tautvydas; Urra, Hery; Viricel, Clement; Wang, Kui; Barakat, Khaled; Hetz Flores, Claudio; Kurgan, Lukasz; Agellon, Luis B.; Michalak, Marek (Nature Publishing Group, 2018)
      © 2018, The Author(s). Cyclosporine, a widely used immunosuppressant in organ transplantation and in treatment of various autoimmune diseases, activates the unfolded protein response (UPR), an ER stress coping response. ...
    • E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells 
      Lobos González, Lorena; Aguilar, Lorena; Díaz Jara, Jorge; Díaz, Natalia; Urra, Hery; Torres Gómez, Vicente; Silva, Verónica; Fitzpatrick, Christopher; Lladser, Álvaro; Hoek, Keith S.; Leyton Campos, Lisette; Quest, Andrew F. G. (2013)
      Theroleofcaveolin-1(CAV1)incancerishighlycontroversial.CAV1suppressesgenesthatfavortumordevelopment, yet also promotes focal adhesion turnover and migration of metastatic cells. How these contrasting observations relate ...
    • Emerging roles of the endoplasmic reticulum associated unfolded protein response in cancer cell migration ... 
      Limia, Celia Maria; Sauzay, Chloé; Urra, Hery; Hetz Flores, Claudio; Chevet, Eric; Avril, Tony (MDPI AG, 2019)
      Endoplasmic reticulum (ER) proteostasis is often altered in tumor cells due to intrinsic (oncogene expression, aneuploidy) and extrinsic (environmental) challenges. ER stress triggers the activation of an adaptive response ...
    • Endoplasmic reticulum proteostasis in glioblastoma - From molecular mechanisms to therapeutic perspectives 
      Obacz, Joanna; Avril, Tony; Le Reste, Pierre Jean; Urra, Hery; Quillien, Véronique; Hetz Flores, Claudio; Chevet, Eric (American Association for the Advancement of Science, 2017)
      © 2017 The Authors, some rights reserved.Cellular stress induced by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) is a central feature of secretory cells and is observed in many tissues in various ...
    • Endoplasmic Reticulum Stress and the Hallmarks of Cancer 
      Urra, Hery; Dufey, Estefanie; Avril, Tony; Chevet, Eric; Hetz Flores, Claudio (Cell Press, 2016)
      © 2016 Elsevier Inc. Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis, thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an adaptive mechanism ...
    • ER proteostasis addiction in cancer biology: Novel concepts 
      Dufey, Estefanie; Urra, Hery; Hetz Flores, Claudio (Academic Press, 2015)
      © 2015 Elsevier Ltd. Endoplasmic reticulum (ER) stress is generated by various physiological and pathological conditions that induce an accumulation of misfolded proteins in its lumen. ER stress activates the unfolded ...
    • Erratum to: IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with ... 
      Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David Leonardo; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, Rene L.; Rodriguez, Diego A.; Rivera, Claudia (Nature Publishing Group, 2018)
      © 2018, The Publisher.In the version of this Article originally published, the competing interests statement was missing. The authors declare no competing interests; this statement has now been added in all online versions ...
    • Helicobacter pylori-induced loss of the inhibitor-of-apoptosis protein survivin is linked to gastritis and ... 
      Valenzuela, Manuel; Pérez Pérez, Guillermo; Corvalán, Alejandro H.; Carrasco, Gonzalo; Urra, Hery; Bravo, Denisse; Toledo, Héctor; Quest, Andrew F. G. (2010)
      Helicobacter pylori infects the human stomach and modifies signaling pathways that affect gastric epithelial cell proliferation and viability. Chronic exposure to this pathogen contributes to the onset of gastric atrophy, ...
    • Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases 
      González Quiroz, Matias; Urra, Hery; Limia, Celia María; Hetz Flores, Claudio (Elsevier, 2018-06)
      Cancer cells are exposed to adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic ...
    • Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic ... 
      Groenendyk, Jody; Peng, Zhenling; Dudek, Elzbieta; Fan, Xiao; Mizianty, Marcin J.; Dufey, Estefanie; Urra, Hery; Sepulveda, Denisse; Rojas-Rivera, Diego; Lim, Yunki; Kim, Do Han; Baretta, Kayla; Srikanth, Sonal; Gwack, Yousang; Ahnn, Joohong; Kaufman, Randal J.; Lee, Sun (American Association for the Advancement of Science, 2014)
      The disruption of the energy or nutrient balance triggers endoplasmic reticulum (ER) stress, a process that mobilizes various strategies, collectively called the unfolded protein response (UPR), which reestablish homeostasis ...
    • IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A 
      Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, René L.; Rodríguez, Diego A.; Rivera, Claudia A.; Court, Felipe A.; Couve Correa, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic Maurer, Álvaro; González Billault, Christian; Hetz Flores, Claudio (Nature, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
    • Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to ... 
      Carreras-Sureda, Amado; Jaña, Fabián; Urra, Hery; Durand, Sylvere; Mortenson, David E.; Sagredo, Alfredo; Bustos, Galdo; Hazari, Younis; Ramos-Fernández, Eva; Sassano, Maria L.; Pihán, Philippe; van Vliet, Alexander R.; González-Quiroz, Matías; Torres, Angie K.; Tapia- (Nature Publishing Group, 2019)
      Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the mitochondrial matrix. Here, we report an unexpected ...
    • Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum ... 
      Carreras-Sureda, Amado; Jaña, Fabián; Urra, Hery; Durand, Sylvere; Mortenson, David E.; Sagredo, Alfredo; Bustos, Galdo; Hazari, Younis; Ramos-Fernández, Eva; Sassano, Maria L.; Pihán, Philippe; van Vliet, Alexander R.; González-Quiroz, Matías; Torres, Angie K.; Tapia- (Nature Publishing Group, 2019)
      An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    • Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from ... 
      Cortés, Juan; Hidalgo, Jorge; Aguilera, Sergio; Castro, Isabel; Brito, Mónica; Urra, Hery; Pérez, Paola; Barrera, María José; Carvajal, Patricia; Urzúa, Ulises; González, Sergio; Molina, Claudio; Bahamondes, Verónica; Hermoso, Marcela; González, María Julieta (Academic Press, 2019)
      Sjögren's syndrome (SS) is an autoimmune exocrinopathy associated with severe secretory alterations by disruption of the glandular architecture integrity, which is fundamental for a correct function and localization of the ...
    • The UPRosome-decoding novel biological outputs of IRE1 alpha function 
      Urra, Hery; Pihan, Philippe; Hetz Flores, Claudio (Company Biologists, 2020)
      Different perturbations alter the function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins in its lumen, a condition termed ER stress. To restore ER proteostasis, a highly conserved ...