Now showing items 1-5 of 5

    • A simple synthesis of 3,4-dihydrobenzo[f]quinoxalin-6(2H)-one derivatives substituted in the ring B 

      Castro Castillo, Vicente; Suárez Rozas, Cristian; Simpson, Sebastián; Barriga González, Andrés (Springer, 2017)
      We followed a simple, inexpensive, and efficient route to synthesize a series of 3,4-dihydrobenzo[f]quinoxalin-6(2H)-one derivatives substituted in the ring B, with the expectation that this scaffold might exhibit ...
    • Annulation of substituted anthracene-9,10-diones yields promising selectively antiproliferative compounds 

      Castro Castillo, Vicente; Suárez Rozas, Cristian; Castro Loiza, Natalia; Theoduloz, Cristina; Cassels Niven, Bruce (Elsevier, 2013)
      Anthraquinone derivatives are well-known antiproliferative compounds, and some are currently used in cancer chemotherapy. Some families of annulated anthraquinone analogs have also been examined for antiproliferative ...
    • Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs 

      Suárez Rozas, Cristian; Simpson, Sebastián; Fuentes Retamal, Sebastián; Catalán, Mabel; Ferreira, Jorge; Theoduloz, Cristina; Mella, Jaime; Cabezas, David; Cassels Niven, Bruce; Yáñez, Claudia; Castro Castillo, Vicente (Elsevier Ltd, 2019)
      © 2018 1,4-Naphthoquinone derivatives have been widely documented with regard to their biological properties, and particularly their anticancer activities. In the 9,10-anthraquinone family, aza-annulation involving one of ...
    • Synthesis and antiplasmodial activity of some 1-azabenzanthrone derivatives 

      Castro Castillo, Vicente; Suárez Rozas, Cristian; Pabón, Adriana; Pérez, Edwin G.; Cassels Niven, Bruce; Blair, Silvia (Elsevier, 2013)
      Some synthetic 1-azabenzanthrones (7H-dibenzo[de,h]quinolin-7-ones) are weakly to moderately cytotoxic, suggesting that they might also show antiparasitic activity. We have now tested a small collection of these compounds ...
    • Telomerase inhibition by a new synthetic derivative of the aporphine alkaloid boldine 

      Noureini, Sakineh Kazemi; Kheirabadi, Mitra; Masoumi, Fatima; Khosrogerdi, Farve; Zarei, Younes; Suárez Rozas, Cristian; Salas Norambuena, Julio; Cassels Niven, Bruce (MDPI, 2018-04)
      Telomerase, the enzyme responsible for cell immortality, is an important target in anti-cancer drug discovery. Boldine, an abundant aporphine alkaloid of Peumus boldus, is known to inhibit telomerase at non-toxic concentrations. ...