Browsing by Author "d0297589-62f5-4999-8b98-21cc31f28e3f"

Now showing items 1-6 of 6

    • Angiotensin-(1-7) prevents lipopolysaccharide-induced autophagy via the mas receptor in skeletal muscle 
      Rivera, Juan Carlos; Abrigo, Johanna; Tacchi, Franco; Simón, Felipe; Brandan, Enrique; Santos, Robson A.; Bader, Michael; Chiong Lay, Mario; Cabello Verrugio, Claudio (MDPI, 2020)
      Skeletal muscle atrophy, which occurs in lipopolysaccharide (LPS)-induced sepsis, causes a severe muscle function reduction. The increased autophagy contributes to sepsis-induced skeletal muscle atrophy in a model of LPS ...
    • Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor 
      Abrigo, Johanna; González, Francisco; Aguirre, Francisco; Tacchi, Franco; González, Andrea; Meza, María Paz; Simón, Felipe; Cabrera, Daniel; Arrese, Marco; Karpen, Saúl; Cabello Verrugio, Claudio (Wiley, 2020)
      Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle-specific E3 ligases, atrogin-1 and MuRF-1, and ...
    • Inhibition of trpm7 protects against inflammatory cytokine overproduction, multiple organ dysfunction, and ... 
      Gatica, Sebastián; Villegas, Vicente; Vallejos, Alejandro; Cabello Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (Lippincott Williams & Wilkins, 2020)
    • Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD) 
      González, Andrea; Huerta Salgado, Camila; Orozco Aguilar, Josué; Aguirre, Francisco; Tacchi, Franco; Simón, Felipe; Cabello Verrugio, Claudio (Hindawi, 2020)
      Nonalcoholic fatty liver disease (NAFLD) is a pathology that contains a broad liver dysfunctions spectrum. These alterations span from noninflammatory isolated steatosis until nonalcoholic steatohepatitis (NASH), a more ...
    • TRPM Channels in Human Diseases 
      Jiménez, Ivanka; Prado, Yolanda; Marchant, Felipe; Otero, Carolina; Eltit, Felipe; Cabello Verrugio, Claudio; Cerda Arancibia, Óscar; Simón, Felipe (MDPI, 2020)
      The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been made in identifying novel members of the TRPM ...
    • TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia 
      Gatica, Sebastián; Villegas, Vicente; Vallejos, Alejandro; Olivares, Pedro; Aballai, Víctor; Lagos Meza, Felipe; Echeverría, César; Cabello Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (Nature Publishing Group, 2020)
      Acute kidney injury and endothelial hyperpermeability are main features observed during severe sepsis with low survival rate. Transient receptor potential melastatin 7 (TRPM7) calcium channel inhibition protects against ...