• Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle 

      Arias Calderón, Manuel; Almarza, Gonzalo; Díaz Vegas, Alexis; Contreras Ferrat, Ariel Eduardo; Valladares Ide, Denisse; Casas Atala, Mariana; Toledo Araya, Héctor; Jaimovich Pérez, Enrique; Buvinic Radic, Sonja (Biomed Central, 2016)
      Background: Electrical activity regulates the expression of skeletal muscle genes by a process known as “ excitation-transcription” (E-T) coupling. We have demonstrated that release of adenosine 5′-triphosphate (ATP) ...
    • Insulin-Dependent H2O2 Production Is Higher in Muscle Fibers of Mice Fed with a High-Fat Diet 

      Espinosa, Alejandra; Campos, Cristian; Díaz Vegas, Alexis; Galgani Fuentes, José Eduardo; Juretic , Nevenka; Osorio Fuentealba, César; Bucarey, José L.; Tapia, Gladys; Valenzuela, Rodrigo; Contreras Ferrat, Ariel Eduardo; Llanos, Paola; Jaimovich Pérez, Enrique (2013)
      Insulin resistance is defined as a reduced ability of insulin to stimulate glucose utilization. C57BL/6 mice fed with a high-fat diet (HFD) are a model of insulin resistance. In skeletal muscle, hydrogen peroxide (H2O2) ...
    • Mitochondrial calcium increase induced by RyR1 and IP3R channel activation after membrane depolarization regulates skeletal muscle metabolism 

      Díaz Vegas, Alexis; Córdova, A.; Valladares, Denisse; Llanos, Paola; Hidalgo, C.; Gherardi, Gaia; Stefani, Diego De; Mammucari, Cristina; Rizzuto, Rosario; Contreras Ferrat, Ariel Eduardo; Jaimovich Pérez, Enrique (Frontiers Media, 2018-06)
      Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by ...
    • NOX2 Inhibition Impairs Early Muscle Gene Expression Induced by a Single Exercise Bout 

      Henríquez Olguín, Carlos; Díaz Vegas, Alexis; Utreras Mendoza, Yildy; Campos Acevedo, Cristian; Arias Calderón, Manuel; Llanos Vidal, Paola; Contreras Ferrat, Ariel Eduardo; Espinosa Escalona, Alejandra; Altamirano, Francisco; Jaimovich Pérez, Enrique; Valladares Ide, Denisse (Frontiers Media, 2016)
      Reactive oxygen species (ROS) participate as signaling molecules in response to exercise in skeletal muscle. However, the source of ROS and the molecular mechanisms involved in these phenomena are still not completely ...
    • NOX2-Dependent ROS Production is Essential for the Response to Endurance Exercise in Skeletal Muscle 

      Henríquez Olguín, Carlos; Valladares Ide, Denisse; Díaz Vegas, Alexis; Utreras Mendoza, Yildy; Campos, Cristian; Llanos, Paola; Contreras Ferrat, Ariel Eduardo; Espinosa Escalona, Alejandra; Altamirano, Francisco; Arias Calderón, Manuel (Federation of American Societies for Experimental Biology, 2015)
    • ROS Production via P2Y(1)-PKC-NOX2 Is Triggered by Extracellular ATP after Electrical Stimulation of Skeletal Muscle Cells 

      Díaz Vegas, Alexis; Campos, Cristian A.; Contreras Ferrat, Ariel Eduardo; Casas Atala, Mariana; Buvinic Radic, Sonja; Jaimovich Pérez, Enrique; Espinosa Escalona, Alejandra (Public Library Science, 2015)
      During exercise, skeletal muscle produces reactive oxygen species (ROS) via NADPH oxidase (NOX2) while inducing cellular adaptations associated with contractile activity. The signals involved in this mechanism are still a ...