Now showing items 1-10 of 10

    • Altered ATP Extrusion and Mitochondrial Calcium Transients in Aged Mice 

      Campo, Andrea del; Contreras, Ignacio; Utreras Mendoza, Yildy; Jaimovich Pérez, Enrique (Federation Amer Soc Exp Biol, 2015)
    • Atrial Function Assessed by Speckle Tracking Echocardiography Is a Good Predictor of Postoperative Atrial Fibrillation in Elderly Patients 

      Verdejo, Hugo E.; Becerra, Elia; Zalaquett Sepúlveda, Ricardo; Campo, Andrea del; García Nannig, Lorena; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Marín, Arnaldo; Castro, Pablo F.; Lavandero González, Sergio; Gabrielli, Luigi A.; Corbalán, Ramón (Wiley & Sons, 2016)
      ObjectiveAdvanced age is an independent predictor of postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass surgery. We evaluated whether left atrial (LA) dysfunction assessed by strain ...
    • Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy 

      Troncoso, Rodrigo; Vicencio, José Miguel; Parra, Valentina; Nemchenko, Andriy; Kawashima, Yuki; Campo, Andrea del; Toro, Barbra; Battiprolu, Pavan K.; Aranguiz, Pablo; Chiong Lay, Mario; Yakar, Shoshana; Gillette, Thomas G.; Hill, Joseph A.; Abel, Evan Dale; LeRoith, Derek; Lavandero González, Sergio (European Society of Cardiology, 2012)
      Aims Insulin-like growth factor 1 (IGF-1) is known to exert cardioprotective actions. However, it remains unknown if autophagy, a major adaptive response to nutritional stress, contributes to IGF-1-mediated cardioprotec ...
    • Increased C-reactive protein plasma levels are not involved in the onset of post-operative atrial fibrillation 

      Campo, Andrea del; Roldán, Juan; Verdejo, Hugo E.; Zalaquett Sepúlveda, Ricardo; Becerra, Elia; Navarro Márquez, Mario; Mellado, Rosemarie; Lavandero González, Sergio; Corbalán, Ramón; García Nannig, Lorena; Chiong Lay, Mario (Elsevier, 2017)
      Background: Increased inflammation biomarkers plasma levels, including C-reactive protein (CRP), have been associated with the initiation and perpetuation of atrial fibrillation (AF). However, it is not known whether an ...
    • Metabolic syndrome and antipsychotics: The role of mitochondrial fission/fusion imbalance 

      Campo, Andrea del; Bustos, Catalina; Mascayano, Carolina; Acuña Castillo, Claudio; Troncoso, Rodrigo; Rojo, Leonel E. (Frontiers Media SA, 2018)
      Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There ...
    • Mifepristone enhances insulin stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells 

      Bernal Sore, Izela; Navarro Márquez, Mario F.; Osorio Fuentealba, César; Díaz Castro, Francisco; Campo, Andrea del; Donoso Barraza, Camila; Porras Espinoza, Omar; Lavandero González, Sergio; Troncoso Cotal, Rodrigo (Elsevier, 2018)
      Mifepristone is the only FDA-approved drug for glycaemia control in patients with Cushing's syndrome and type 2 diabetes. Mifepristone also has beneficial effects in animal models of diabetes and patients with antipsychotic ...
    • Mifepristone for treatment of metabolic syndrome: beyond cushing’s syndrome 

      Díaz Castro, Francisco; Monsalves Álvarez, Matías; Rojo, Leonel E.; Campo, Andrea del; Troncoso, Rodrigo (Frontiers Media, 2020)
      A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic ...
    • Mitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old Characters 

      Campo, Andrea del; Jaimovich Pérez, Enrique; Tevy, María Florencia (Hindawi, 2016)
      Sarcopenia is the loss of muscle mass accompanied by a decrease in muscle strength and resistance and is the main cause of disability among the elderly. Muscle loss begins long before there is any clear physical impact in ...
    • Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice 

      Campo, Andrea del; Contreras Hernández, Ignacio Alejandro; Castro Sepúlveda, Mauricio; Campos, Cristian; Figueroa, Reinaldo; Florencia Tevy, María; Eisner, Verónica; Casas Atala, Mariana; Jaimovich Pérez, Enrique (Impact Journals LLC, 2018)
      Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial ...
    • Regulation of autophagy by Insulin/IGF-1 signaling pathways 

      Troncoso, Rodrigo; Vásquez Trincado, César; Campo, Andrea del; Gatica, Damián; Morales, Pablo; Paredes, Felipe; Gutiérrez, Tomás; López Crisosto, Camila; Lavandero González, Sergio; Torrealba, Natalia; García Nannig, Lorena; Díaz Araya, Guillermo; Battiprolu, Pavan K.; Nemchenko, Andriy; Ferdous, Anwarul; Gillette, Thomas G.; Hill, Joseph A. (Nova Science Publishers, 2012)