Browsing by Author "d67b1b47-7410-4188-ad3c-2d8d6a25e4cc"
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Lagos, Carlos F.; Araya Secchi, Raúl; Thomas, Pablo; Pérez-Acle, Tomás; Tapia, Ricardo A.; Salas, Cristian O. (2012)Trypanosoma cruzi glutamate cysteine ligase (TcGCL) is considered a potential drug target to develop novel antichagasic drugs. We have used a variety of computational methods to investigate the interactions between TcGCL ...
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Areche, Carlos; Cejas, Patricia; Thomas, Pablo; San Martín Barrientos, Aurelio; Astudillo, Luis; Gutiérrez, Margarita; Loyola, Luis A. (Sociedade Brasileira de Quimica, 2009)The inhibition of the enzyme acetylcholinesterase is considered as a strategy for the treatment of Alzheimer's disease, senile dementia, ataxia, and myasthenia gravis. Three lanostane- and two cycloartane-type triterpenes, ...