Now showing items 1-14 of 14

    • A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway 

      Zamorano, Sebastián; Rojas Rivera, Diego; Lisbona, Fernanda; Parra, Valentina; Court, Felipe A.; Villegas, Rosario; Cheng, Emily H.; Korsmeyer, Stanley J.; Lavandero González, Sergio; Hetz Flores, Claudio (2012)
      Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
    • Abrogation of prostaglandin E-2/EP4 signaling impairs the development of rag1(+) lymphoid precursors in the thymus of zebrafish embryos 

      Villablanca, Eduardo J.; Pistocchi, Anna; Court, Felipe A.; Cotelli, Franco; Bordignon, Claudio; Allende Connelly, Miguel; Traversari, Catia; Russo, Vincenzo (2007)
      PGE(2) is involved in a wide variety of physiological and pathological processes; however, deciphering its role in early Mammalian development has been difficult due to the maternal contribution of PGE(2). To overcome this ...
    • Abrogation of prostaglandin E2/EP4 signaling impairs the development of rag1+ lymphoid precursors in the thymus of zebrafish embryos 

      Villablanca, Eduardo J.; Pistocchi, Anna; Court, Felipe A.; Cotelli, Franco; Bordignon, Claudio; Allende Connelly, Miguel; Traversari, Catia; Russo, Vincenzo (American Association of Immunologists, 2007)
      PGE2 is involved in a wide variety of physiological and pathological processes; however, deciphering its role in early mammalian development has been difficult due to the maternal contribution of PGE 2. To overcome this ...
    • Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore 

      Barrientos, Sebastián A.; Martínez, Nicolas W.; Yoo, Soonmoon; Jara, Juan S.; Zamorano, Sebastián; Hetz Flores, Claudio; Twiss, Jeffery L.; Alvarez, Jaime; Court, Felipe A. (SOC NEUROSCIENCE, 2011-01-19)
      Axonal degeneration is an active process that has been associated with neurodegenerative conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory stimuli. This degenerative process can ...
    • Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve 

      González Roca, Carolina; Cánovas, José; Fresno, Javiera; Couve, Eduardo; Court, Felipe A.; Couve Correa, Andrés (National Academy of Sciences, 2016)
      The regulation of the axonal proteome is key to generate and maintain neural function. Fast and slow axoplasmic waves have been known for decades, but alternative mechanisms to control the abundance of axonal proteins based ...
    • BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response 

      Castillo, Karen; Rojas Rivera, Diego; Lisbona, Fernanda; Caballero, Benjamín; Nassif, Melissa; Court, Felipe A.; Schuck, Sebastian; Ibar, Consuelo; Walter, Peter; Sierralta, Jimena; Glavic Maurer, Álvaro; Hetz Flores, Claudio (2011)
      Both autophagy and apoptosis are tightly regulated processes playing a central role in tissue homeostasis. Bax inhibitor 1 (BI-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (ER) ...
    • Bursting the unfolded protein response accelerates axonal regeneration 

      Oñate, Maritza; Court, Felipe A.; Hetz Flores, Claudio (Medknow Publications, 2016)
    • Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1 

      Valdés, Pamela; Mercado, Gabriela; Vidal, René L.; Molina, Claudia; Parsons, Geoffrey; Court, Felipe A.; Martínez, Alexis; Galleguillos, Danny; Armentano, Donna; Schneider, Bernard L.; Hetz Flores, Claudio (CrossMark, 2014)
      Parkinson disease (PD) is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta (SNpc). Although growing evidence indicates that endoplasmic reticulum (ER) stress is a hallmark ...
    • Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43(A315T) ALS/FTD mouse model 

      Bargsted, Leslie; Medinas Bilches, Danilo; Martínez Traub, Francisca; Rozas, Pablo; Muñoz, Natalia; Nassif, Melissa; Jerez, Carolina; Catenaccio, Alejandra; Court, Felipe A.; Hetz Flores, Claudio; Matus, Soledad (Nature Publishing Group, 2017)
      Tar DNA binding protein 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tissue of most cases of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ...
    • Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration 

      Castillo, Valentina; Oñate, Maritza G.; Woehlbier, Ute; Rozas, Pablo; Andreu, Catherine; Medinas Bilches, Danilo; Valdés, Pamela; Osorio, Fabiola; Mercado, Gabriela; Vidal, René L.; Kerr, Bredford; Court, Felipe A.; Hetz Flores, Claudio (Public Library Science, 2015)
      ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes disulfide bonds formation of glycoproteins as part of the calnexin and calreticulin cycle. ERp57 is markedly upregulated in most common ...
    • Injury to the nervous system: A look into the ER 

      Valenzuela, Vicente; Oñate, Maritza; Hetz Flores, Claudio; Court, Felipe A. (Elsevier B.V., 2016)
      © 2016 Elsevier B.V.Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves ...
    • IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A 

      Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, René L.; Rodríguez, Diego A.; Rivera, Claudia A.; Court, Felipe A.; Couve Correa, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic Maurer, Álvaro; González Billault, Christian; Hetz Flores, Claudio (Nature, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
    • Mitochondria and calcium regulation as basis of neurodegeneration associated with aging 

      Müller, Marioly; Ahumada-Castro, Ulises; Sanhueza, Mario; González Billault, Christian; Court, Felipe A.; Cárdenas, César (Frontiers Media S.A., 2018)
      © 2018 Müller, Ahumada-Castro, Sanhueza, Gonzalez-Billault, Court and Cárdenas.Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several ...
    • The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease 

      Oñate, Maritza; Catenaccio, Alejandra; Salvadores, Natalia; Saquel, Cristian; Martínez Rojas, Luis; Moreno González, Inés; Gamez, Nazaret; Soto, Paulina; Soto, Claudio; Hetz Flores, Claudio; Court, Felipe A. (Nature Publishing Group, 2020)