Browsing by Author "dca0bbca-0161-41dc-9cfb-fd5cb73e96a3"

Now showing items 1-5 of 5

    • Anti-Diabetic Agent Sodium Tungstate Induces the Secretion of Pro- and Anti-Inflammatory Cytokines by Human ... 
      Bertinat, Romina; Westermeier, Francisco; Silva, Pamela; Shi, Jie; Nualart, Francisco; Li, Xuhang; Yáñez, Alejandro J. (Wiley-Liss Inc., 2017)
      © 2016 Wiley Periodicals, Inc. Diabetic kidney disease (DKD) is the major cause of end stage renal disease. Sodium tungstate (NaW) exerts anti-diabetic and immunomodulatory activities in diabetic animal models. Here, we ...
    • Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus 
      Westermeier, Francisco; Sáez, T.; Arroyo, P.; Toledo, F.; Gutiérrez, J.; Sanhueza, C.; Pardo, F.; Leiva, A.; Sobrevia, L. (Wiley-Blackwell, 2016)
      The human insulin receptor (IR) exists in two isoforms that differ by the absence (IR-A) or the presence (IR-B) of a 12-amino acid segment encoded by exon 11. Both isoforms are functionally distinct regarding their binding ...
    • Modulation of endothelial cell migration by ER stress and insulin resistance: A role during maternal obesity? 
      Sáez, Pablo J.; Villalobos-Labra, Roberto; Westermeier, Francisco; Sobrevia, Luis; Farías-Jofré, Marcelo (Frontiers Research Foundation, 2014)
      Adverse microenvironmental stimuli can trigger the endoplasmic reticulum (ER) stress pathway, which initiates the unfolded protein response (UPR), to restore protein-folding homeostasis. Several studies show induction of ...
    • New Molecular Insights of Insulin in Diabetic Cardiomyopathy 
      Westermeier, Francisco; Riquelme, Jaime A.; Pavez, Mario; Garrido, Valeria; Díaz, Ariel; Verdejo, Hugo E.; Castro, Pablo F.; García Nannig, Lorena; Lavandero González, Sergio (Frontiers Media S.A., 2016-04)
      Type 2 diabetes mellitus (T2DM) is a highly prevalent disease worldwide. Cardiovascular disorders generated as a consequence of T2DM are a major cause of death related to this disease. Diabetic cardiomyopathy (DCM) is ...
    • Programming of fetal insulin resistance in pregnancies with maternal obesity by ER stress and inflammation 
      Westermeier, Francisco; Sáez, Pablo J.; Villalobos-Labra, Roberto; Sobrevia, Luis; Farías-Jofré, Marcelo (Hindawi Publishing Corporation, 2014)
      The global epidemics of obesity during pregnancy and excessive gestational weight gain (GWG) are major public health problems worldwide. Obesity and excessive GWG are related to several maternal and fetal complications, ...