Browsing by Author "e1aed6cf-4d7c-493e-825b-6519a762dcaf"
Now showing items 1-11 of 11
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Aravena, Javier; Abrigo, Johanna; González, Francisco; Aguirre, Francisco; González, Andrea; Simon Pino, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)Myostatin is a myokine that regulates muscle function and mass, producing muscle atrophy. Myostatin induces the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. The main pathway that mediates ...
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Abrigo, Johanna; González, Francisco; Aguirre, Francisco; Tacchi, Franco; González, Andrea; Meza, María Paz; Simón, Felipe; Cabrera, Daniel; Arrese, Marco; Karpen, Saúl; Cabello Verrugio, Claudio (Wiley, 2020)Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle-specific E3 ligases, atrogin-1 and MuRF-1, and ...
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Maccioni Baraona, Ricardo; Navarrete, Leonardo P.; González, Andrea; González Canacer, Alejandra; Guzmán Martínez, Leonardo; Cortes, Nicole (IOS Press, 2020)Several hypotheses have been postulated to explain how Alzheimer's disease is triggered, but none of them provide a unified view of its pathogenesis. The dominant hypothesis based on build-ups of the amyloid-beta peptide ...
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Andrade, Víctor; Cortés, Nicole; Pastor, Gabriela; González, Andrea; Ramos Escobar, Nicolás; Pastene, Edgar; Rojo, Leonel E.; Maccioni Baraona, Ricardo (IOS Press, 2020)Background: Alzheimer's disease (AD) is a multifactorial disease, that involves neuroinflammatory processes in which microglial cells respond to "damage signals". The latter includes oligomeric tau, iron, oxidative free ...
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González, Andrea; Guzmán Martínez, Leonardo; Maccioni Baraona, Ricardo (IOP Publishing, 2020)Background: A major drawback in Alzheimer's disease (AD) is the lack of validated biomarkers for routine clinical diagnostic. We have reported earlier a novel blood biomarker, named Alz-tau (R), based on variants of platelet ...
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Aguirre, Francisco; Abrigo, Johanna; Altimiras González, Francisco; González, Andrea; Simon, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)Sarcopenia associated with chronic liver disease (CLD) is one of the more common extrahepatic features in patients with these pathologies. Among the cellular alterations observed in the muscle tissue under CLD is the decline ...
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González, Andrea; Huerta Salgado, Camila; Orozco Aguilar, Josué; Aguirre, Francisco; Tacchi, Franco; Simón, Felipe; Cabello Verrugio, Claudio (Hindawi, 2020)Nonalcoholic fatty liver disease (NAFLD) is a pathology that contains a broad liver dysfunctions spectrum. These alterations span from noninflammatory isolated steatosis until nonalcoholic steatohepatitis (NASH), a more ...
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Abrigo, Johanna; Campos, Fabián; González, Francisco; Aguirre, Francisco; González, Andrea; Huerta Salgado, Camila; Conejeros, Sabrina; Simon, Felipe; Arrese, Marco; Cabrera, Daniel; Elorza, Alvaro A.; Cabello Verrugio, Claudio (MDPI, 2020)Sarcopenia is a condition of muscle dysfunction, commonly associated with chronic liver disease (CLD), characterized by a decline in muscle strength, the activation of the ubiquitin-proteasome system (UPS), and oxidative ...
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González, Andrea; Orozco Aguilar, Josué; Achiardi, Óscar; Simon, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has produced significant health emergencies worldwide, resulting in the declaration by the World Health Organization of the coronavirus disease 2019 (COVID-19) ...
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Calfio, Camila; González, Andrea; Singh, Sandeep Kumar; Rojo, Leonel E.; Maccioni, Ricardo B. (IOS Press, 2020)One of the major challenges of medical sciences has been finding a reliable compound for the pharmacological treatment of Alzheimer's disease (AD). As most of the drugs directed to a variety of targets have failed in finding ...
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González, Andrea; Nova, Esteban; Campo, Miguel del; Manubens, Augusto; Ioannes, Alfredo de; Ferreira Parker, Jorge; Becker, María Inés (Elsevier, 2017)Hemocyanins have highly conserved copper-containing active sites that bind oxygen. However, structural differences among the hemocyanins of various mollusks may affect their physicochemical properties. Here, we studied ...