Now showing items 1-20 of 31

    • ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans 

      Boekstegers, Félix; Marcelain Cubillos, Katherine; Barahona Ponce, Carol; Báez Benavides, Pablo F.; Müller, Bettina; Toro, Gonzalo de; Retamales, Javier; Barajas Barajas, Olga; Ahumada Olea, Mónica; Morales, Erik; Rojas, Armando; Sanhueza, Verónica; Loader, Denisse; Rivera, María Teresa; Gutiérrez, Lorena; Bernal, Giuliano; Ortega, Alejandro; Montalvo, Domingo; Portiño, Sergio; Bertrán, María Enriqueta; Gabler, Fernando; Spencer, Loreto; Olloquequi, Jordi; González Silos, Rosa; Fischer, Christine; Scherer, Dominique; Jenab, Mazda; Aleksandrova, Krasimira; Katzke, Verena; Weiderpass, Elisabete; Moradi, Tahereh; Fischer, Krista; Bossers, Willem; Brenner, Hermann; Hveem, Kristian; Eklund, Niina; Völker, Uwe; Waldenberger, Melanie; Fuentes Guajardo, Macarena; González-José, Rolando; Bedoya, Gabriel; Bortolini, María C.; Canizales, Samuel; Gallo, Carla; Ruiz Linares, Andrés; Rothhammer, Francisco; Bermejo, Justo Lorenzo (Elsevier, 2020)
      Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. ...
    • ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response 

      Sagredo, Eduardo A.; Sagredo, Alfredo I.; Blanco, Alejandro; Rojas De Santiago, Pamela; Rivas, Solange; Assar Cuevas, Rodrigo; Pérez, Paola; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (Elsevier, 2020)
      RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
    • ADAR1-mediated RNA-editing of 3'UTRs in breast cancer 

      Sagredo, Eduardo A.; Blanco, Alejandro; Sagredo, Alfredo I.; Pérez, Paola; Sepúlveda-Hermosilla, Gonzalo; Morales, Fernanda; Müller, Bettina; Verdugo, Ricardo; Marcelain Cubillos, Katherine; Harismendy, Olivier; Armisén, Ricardo (NLM (Medline), 2018)
      RESULTS: We characterized A to G(I) mRNA editing in 81 breast cell lines, showing increased editing at 3'UTR and exonic regions in breast cancer cells compared to immortalized non-malignant cell lines. In addition, tumors ...
    • Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome 

      Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Arriagada, Christian; Paris Pizarro, Irmgard; Caviedes Fernández, Pablo; Caviedes, R.; Segura Aguilar, Juan (2000)
      Angiotensin receptor II mRNA was found to be expressed in dopaminergic neuronal cell line RCSN3 of rat substantia nigra using RT-PCR reaction. Aminochrome (150 μM), a metabolite of the dopamine oxidative pathway, was found ...
    • Caracterización clínica, citogenética y molecular de un nuevo caso de síndrome de Nijmegen en Chile 

      Marcelain Cubillos, Katherine; Aracena A., Mariana; Be R., Cecilia; Navarrete Suárez, Carmen; Moreno H., Rosa; Santos A., Manuel; Pincheira Vega, Juana (SOC MEDICA SANTIAGO, 2004-02)
      The Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive disorder associated with microcephaly, immunodeficiency, chromosome instability and cancer proneness. The mutated gene that results in NBS codes for ...
    • Chromosomal Instability in Mouse Embryonic Fibroblasts Null for the Transcriptional Co-Repressor Ski 

      Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Aguirre, Adam; Ueki, Nobuhide; Toro, Jessica; Colmenares, Clemencia; Hayman, Michael J. (WILEY-BLACKWELL, 2012-01)
      Ski is a transcriptional regulator that has been considered an oncoprotein given its ability to induce oncogenic transformation in avian model systems. However, studies in mouse and in some human tumor cells have also ...
    • CK2 functionally interacts with AKT/PKB to promote the β-catenin- dependent expression of survivin and enhance cell survival 

      Ponce, Daniela P.; Yefi, Roger; Cabello, Pablo; Maturana, Jose L.; Niechi, Ignacio; Silva, Eduardo; Galindo, Mario; Antonelli, Marcelo; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Tapia, Julio C. (2011)
      β-Catenin is crucial in the canonical Wnt signaling pathway. This pathway is up-regulated by CK2 which is associated with an enhanced expression of the antiapoptotic protein survivin, although the underlying molecular ...
    • Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability 

      Niechi, Ignacio; Silva, Eduardo; Cabello, Pablo; Huerta, Hernán; Carrasco, Valentina; Villar, Paulina; Cataldo, Luis; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Varas Godoy, Manuel; Fernández, Cristina; Tapia, Julio (Impact Journals LLC, 2015)
      Endothelin-converting enzyme-1c (ECE-1c) is a membrane metalloprotease involved in endothelin-1 synthesis, which has been shown in vitro to have a role in breast, ovary and prostate cancer cell invasion. N-terminal end of ...
    • Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line 

      Paris Pizarro, Irmgard; Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Bennett, L. B.; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Olea Azar, Claudio; Segura Aguilar, Juan (BLACKWELL SCIENCE LTD, 2001-04)
      The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
    • Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth 

      Colombo, Alicia; Palma, Karina; Armijo, Lorena; Mione, Marina; Signore, Iskra A.; Morales, Camila; Guerrero, Néstor; Meynard, Margarita M.; Pérez, Ramón; Suazo, José; Marcelain Cubillos, Katherine; Briones, Luis; Härtel, Steffen; Wilson, Stephen W.; Concha Nordemann, Miguel (The Company of Biologists, 2013)
      Although progress has been made in resolving the genetic pathways that specify neuronal asymmetries in the brain, little is known about genes that mediate the development of structural asymmetries between neurons on left ...
    • Differential miRNA expression profiling reveals miR-205-3p to be a potential radiosensitizer for low- dose ionizing radiation in DLD-1 cells 

      Andaur, Rodrigo; Tapia, Julio C.; Moreno, José; Soto, Leopoldo; Armisen, Ricardo; Marcelain Cubillos, Katherine (Impact Journals LLC, 2018)
      © Andaur et al. Enhanced radiosensitivity at low doses of ionizing radiation (IR) (0.2 to 0.6 Gy) has been reported in several cell lines. This phenomenon, known as low doses hyperradiosensitivity (LDHRS), appears as an ...
    • Effect of vitamin E (DL α-tocopherol) on chromosomal damage in lymphocytes from patients with ataxia telangiectasia Efecto de la vitamina E (DL α-tocoferol) sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia 

      Marcelain Cubillos, Katherine; Luz Navarrete S, Carmen; Bravo L, Mireya; Santos A, Manuel; Be R, Cecilia; Pincheira V, Juana (2002)
      Background: In ataxia telangiectasia (A-T), the lack of a functional ATM kinase is associated with disturbances in the processing of DNA damage and a chronic oxidative stress. These disturbances may be responsible for an ...
    • Epitelización inducida por células troncales derivadas del tejido adiposo 

      Meruane, M.; Benítez Seguel, Susana Alejandra; Rojas, M.; Sagredo, A.; Marcelain Cubillos, Katherine; Villalobos, B. (Sociedad Española de Cirugía Plástica, Reparadora y Estética (SECPRE), 2014)
      El tratamiento de lesiones con pérdida de tejido cutáneo ha mejorado notablemente con el advenimiento de la bioingeniería tisular. Una alternativa en desarrollo es la utilización de sustitutos dérmicos combinados con células ...
    • G2 checkpoint-dependent DNA repair and its response to catalase in Down syndrome and control lymphocyte cultures 

      Pincheira, Juana; Romero, Pablo; Marcelain Cubillos, Katherine; Salazar, Lorena; de la Torre, Consuelo (2007)
      The amount of DNA lesions repaired in G2 and also G2 timing are controlled by the DNA damage-dependent checkpoint. Down syndrome (DS) lymphocytes showed twice as much constitutive DNA damage in G2 than control ones, when ...
    • Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation 

      Jain, J.; Moreno, J.; Andaur, R.; Armisen Yáñez, Ricardo; Morales D., Ignacio; Marcelain Cubillos, Katherine; Avaria, G.; Bora, B.; Davis, S.; Pavez, C.; Soto, L. (American Institute of Physics, 2017)
      Plasma focus devices may arise as useful source to perform experiments aimed to study the effects of pulsed radiation on human cells in vitro. In the present work, a table top hundred joules plasma focus device, namely ...
    • Identification of Ski as a target for Aurora A kinase 

      Mosquera, Jocelyn; Armisen Yáñez, Ricardo; Zhao, Hongling; Rojas, Diego A.; Maldonado, Edio; Tapia, Julio C.; Colombo, Alicia; Hayman, Michael J.; Marcelain Cubillos, Katherine (2011)
      Ski is a negative regulator of the transforming growth factor-β and other signalling pathways. The absence of SKI in mouse fibroblasts leads to chromosome segregation defects and genomic instability, suggesting a role for ...
    • In vitro irradiation of colorectal cancer cells by pulsed radiation emitted from a hundred joules plasma focus device and its comparison with continuous irradiation 

      Jain, J.; Moreno, J.; Andaur, R.; Armisen, R.; Avaria, G.; Bora, B.; Davis, S.; Pavez, C.; Marcelain Cubillos, Katherine; Soto, L. (Institute of Physics Publishing, 2018)
      In the last years, pulsed reduced low dose radiation has been proposed as an alternative for treatment of recurrent cancer. Nonetheless, distinction between the effects of low dose pulsed and continuous radiation is barely ...
    • Inhibition of the 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Induces Orofacial Defects in Zebrafish 

      Signore Ahumada, Iskra; Jerez, Carolina; Figueroa, Diego; Suazo Sanhueza, José Lorenzo; Marcelain Cubillos, Katherine; Cerda Arancibia, Óscar; Colombo Flores, Alicia (Wiley, 2016)
      Background: Orofacial clefts (OFCs) are common birth defects, which include a range of disorders with a complex etiology affecting formation of craniofacial structures. Some forms of syndromic OFCs are produced by defects ...
    • Nijmegen breakage syndrome: follow up of seven cases in Chile 

      Aracena, M.; Cares, C.; Arredondo, S.; Marcelain Cubillos, Katherine; González Hormazábal, Patricio (Wiley, 2018)
    • Parity history determines a systemic inflammatory response to spread of ovarian cancer in naturally aged mice 

      Urzúa Tobar, Ulises; Chacón, Carlos; Lizama, Luis; Sarmiento, Sebastián; Villalobos, Pía; Kroxato, Belén; Marcelain Cubillos, Katherine; González Burgos, María Julieta (International Society on Aging and Disease, 2017)
      Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly ...