Browsing by Author "e1f48925-9ea4-4865-a023-bf7807874732"

Now showing items 1-11 of 11

    • ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans 
      Boekstegers, Félix; Marcelain Cubillos, Katherine; Barahona Ponce, Carol; Báez Benavides, Pablo F.; Müller, Bettina; Toro, Gonzalo de; Retamales, Javier; Barajas Barajas, Olga; Ahumada Olea, Mónica; Morales, Erik; Rojas, Armando; Sanhueza, Verónica; Loader, Denisse; Rivera, María Teresa; Gutiérrez, Lorena; Bernal, Giuliano; Ortega, Alejandro; Montalvo, Domingo; Portiño, Sergio; Bertrán, María Enriqueta; Gabler, Fernando; Spencer, Loreto; Olloquequi, Jordi; González Silos, Rosa; Fischer, Christine; Scherer, Dominique; Jenab, Mazda; Aleksandrova, Krasimira; Katzke, Verena; Weiderpass, Elisabete; Moradi, Tahereh; Fischer, Krista; Bossers, Willem; Brenner, Hermann; Hveem, Kristian; Eklund, Niina; Völker, Uwe; Waldenberger, Melanie; Fuentes Guajardo, Macarena; González-José, Rolando; Bedoya, Gabriel; Bortolini, María C.; Canizales, Samuel; Gallo, Carla; Ruiz Linares, Andrés; Rothhammer, Francisco; Bermejo, Justo Lorenzo (Elsevier, 2020)
      Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. ...
    • ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA ... 
      Sagredo, Eduardo A.; Sagredo, Alfredo I.; Blanco, Alejandro; Rojas De Santiago, Pamela; Rivas, Solange; Assar Cuevas, Rodrigo; Pérez, Paola; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (Elsevier, 2020)
      RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
    • Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated ... 
      Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Arriagada, Christian; Paris Pizarro, Irmgard; Caviedes Fernández, Pablo; Caviedes, R.; Segura Aguilar, Juan (2000)
      Angiotensin receptor II mRNA was found to be expressed in dopaminergic neuronal cell line RCSN3 of rat substantia nigra using RT-PCR reaction. Aminochrome (150 μM), a metabolite of the dopamine oxidative pathway, was found ...
    • Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation 
      Jain, J.; Moreno, J.; Andaur, R.; Armisen Yáñez, Ricardo; Morales D., Ignacio; Marcelain Cubillos, Katherine; Avaria, G.; Bora, B.; Davis, S.; Pavez, C.; Soto, L. (American Institute of Physics, 2017)
      Plasma focus devices may arise as useful source to perform experiments aimed to study the effects of pulsed radiation on human cells in vitro. In the present work, a table top hundred joules plasma focus device, namely ...
    • Inhibition of the 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Induces Orofacial Defects in Zebrafish 
      Signore Ahumada, Iskra; Jerez, Carolina; Figueroa, Diego; Suazo Sanhueza, José Lorenzo; Marcelain Cubillos, Katherine; Cerda Arancibia, Óscar; Colombo Flores, Alicia (Wiley, 2016)
      Background: Orofacial clefts (OFCs) are common birth defects, which include a range of disorders with a complex etiology affecting formation of craniofacial structures. Some forms of syndromic OFCs are produced by defects ...
    • Nijmegen breakage syndrome: follow up of seven cases in Chile 
      Aracena, M.; Cares, C.; Arredondo, S.; Marcelain Cubillos, Katherine; González Hormazábal, Patricio (Wiley, 2018)
    • Parity history determines a systemic inflammatory response to spread of ovarian cancer in naturally aged mice 
      Urzúa Tobar, Ulises; Chacón, Carlos; Lizama, Luis; Sarmiento, Sebastián; Villalobos, Pía; Kroxato, Belén; Marcelain Cubillos, Katherine; González Burgos, María Julieta (International Society on Aging and Disease, 2017)
      Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly ...
    • Patient-derived organoids as a potential tool for clinical decision in advanced gallbladder cancer 
      Obreque, Javiera; Vergara, Luis; Suárez, Felipe; García, Patricia; Marcelain Cubillos, Katherine; Toro, Jessica; Solange, Rivas; Rosa, Lorena; Roa, Juan Carlos; Nervi, Bruno; Viñuela, Eduardo; Aguayo, Gloria; Muniz Muñoz, Sabrina; Caire, Nicole; Escalante, Anrried; Mondaca, Sebastián; Nervi, Bruno (Lippincott Williams & Wilkins, 2020)
    • RNA Sequencing of hepatobiliary cancer cell lines: Data and applications to mutational and transcriptomic profiling 
      Scherer, Dominique; Dávila López, Marcela; Goeppert, Benjamín; Abrahamsson, Sanna; González Silos, Rosa; Nova, Igor; Marcelain Cubillos, Katherine; Roa, Juan C.; Ibberson, David; Umu, Sinan U.; Ballestad Rounge, Trine; Roessler, Stephanie; Bermejo, Justo Lorenzo (MDPI, 2020)
      Simple Summary Research on gallbladder cancer (GBC) has been largely neglected and molecular GBC data is underrepresented in public databases. Cancer cell lines constitute a valuable tool to examine the mechanisms of ...
    • Ski Is required for tri-methylation of H3K9 in major satellite and for repression of pericentromeric genes: ... 
      Cappelli, Claudio; Sepúlveda, Hugo; Rivas Vera, Solange; Pola Véliz, Víctor; Urzúa Tobar, Ulises; Donoso Luna, Gerardo; Sagredo Campos, Eduardo; Carrero Zapata, David; Casanova Ortiz, Emmanuel; Sagredo Campos, Alfredo; González Vergara, Marisel; Manterola Zúñiga, Marcia; Nardocci, Gino; Armisén Yañez, Ricardo; Montecino, Martín; Marcelain Cubillos, Katherine (Elsevier, 2020)
      Several mechanisms directing a rapid transcriptional reactivation of genes immediately after mitosis have been described. However, little is known about the maintenance of repressive signals during mitosis. In this work, ...
    • Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations ... 
      Bermejo, Justo Lorenzo; Boekstegers, Félix; González Silos, Rosa; Marcelain Cubillos, Katherine; Báez Benavides, Pablo; Barahona Ponce, Carol; Mueller, Bettina; Ferreccio, Catterina; Koshiol, Jill; Fischer, Christine; Peil, Barbara; Sinsheimer, Janet; Fuentes Guajardo, Macarena; Barajas Barajas, Olga; González José, Rolando; Bedoya, Gabriel; Bortolini, María Catira; Canizales Quinteros, Samuel; Gallo, Carla; Ruiz Linares, Andrés; Rothhammer Engel, Francisco (Public Library Science, 2017)
      Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and ...