Now showing items 1-17 of 17

    • A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-β+ tolerogenic dendritic cells 

      López, Mercedes N.; Pesce Reyes, Bárbara; Kurte, Mónica; Pérez, Claudio; Segal, Gabriela; Roa, Johanna; Aguillón Gutiérrez, Juan Carlos; Mendoza Naranjo, Ariadna; Gesser, Borbala; Larsen, Christian; Villablanca, Andrea; Choudhury, Aniruddha; Kiessling, Rolf; Salazar Onfray, Flavio (2011)
      We have previously demonstrated that IT9302, a nonameric peptide homologous to the C-terminal domain of human IL-10, mimics several effects of the cytokine including down-regulation of the antigen presentation machinery ...
    • Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells 

      Torres, Angelo; Vargas, Yosselyn; Uribe, Daniel; Jaramillo, Catherine; Gleisner Muñoz, María Alejandra; Salazar Onfray, Flavio; López, Mercedes N.; Melo, Rómulo; Oyarzún, Carlos; Martín, Rody San; Quezada, Claudia (Impact Journals LLC, 2016)
      MRP1 transporter correlates positively with glioma malignancy and the Multiple Drug Resistance (MDR) phenotype in Glioblastoma Multiforme (GBM). Evidence shows that the MRP1 transporter is controlled by the adenosine ...
    • Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside 

      Palacios, Miriam; Tampe, Ricardo; Campo, Miguel del; Zhong, Ta-Ying; López, Mercedes N.; Salazar Onfray, Flavio; Becker, María Inés (Elsevier, 2018-04-25)
      Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is the case for peptides mimicking carbohydrate tumor-associated antigens in cancer vaccine development. The most used protein for ...
    • Dendritic cell chimerism in oral mucosa of transplanted patients affected by graft-versus-host disease 

      Pérez, Claudio A.; Rabanales, Ramón; Rojas Alcayaga, Gonzalo; Larrondo Lillo, Milton; Escobar Álvarez, Alejandro; López, Mercedes N.; Salazar Onfray, Flavio; Alfaro Lucero, Jorge; González, Fermin E. (John Wiley & Sons, 2016)
      ObjectiveGraft-versus-host disease (GVHD) is one of the main complications after haematopoietic stem cell transplantation. Clinical features of GVHD include either an acute (aGVHD) or a chronic (cGVHD) condition that affects ...
    • Interleukin 10 decreases MICA expression on melanoma cell surface 

      Serrano, Antonio E.; Menares Castillo, Evelyn; Garrido Tapia, Macarena; Hager Ribeiro, Carolina; Hernández, Carolina J.; Mendoza Naranjo, Ariadna; Gatica Andrades, Marcela; Valenzuela Díaz, Rodrigo; Zúñiga, Roberto; López, Mercedes N.; Salazar Onfray, Flavio; Aguillón, Juan Carlos (2011)
      Natural-killer group 2, member D (NKG2D) binds to a variety of ligands, including the major histocompatibility complex (MHC) class I chain-related proteins (MIC) and UL16-binding proteins (ULBP). It is regarded as a ...
    • Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy 

      López, Mercedes N.; Pereda, Cristian; Ramírez, Marcos; Mendoza Naranjo, Ariadna; Serrano, Antonio; Ferreira, Arturo; Poblete, Rodrigo; Kalergis, Alexis M.; Kiessling, Rolf; Salazar Onfray, Flavio (2007)
      PURPOSE. Uveal melanoma is the most common primary malignant ocular cancer in adults. This tumor has a distinct expression pattern of markers compared with cutaneous melanoma. MC1R is under study as a potential target ...
    • Molecular signatures associated with tumor-specific immune response in melanoma patients treated with dendritic cell-based immunotherapy 

      García-Salum, Tamara; Villablanca, Andrea; Matthäus, Franziska; Tittarelli, Andrés; Baeza, Mauricio; Pereda, Cristián; Gleisner Muñoz, María Alejandra; González, Fermín E.; López, Mercedes N.; Hoheisel, Jörg D.; Norgauer, Johannes; Gebicke Haerter, Peter J.; Salazar Onfray, Flavio (Impact Journals LLC, 2018)
      © García-Salum et al. Purpose: We previously showed that autologous dendritic cells (DCs) loaded with an allogeneic heat shock (HS)-conditioned melanoma cell-derived lysate, called TRIMEL, induce T-cell-mediated immune ...
    • Molluskan hemocyanins activate the classical pathway of the human complement system through natural antibodies 

      Pizarro Bauerle, Javier; Maldonado, Ismael; Sosoniuk Roche, Eduardo Rodrigo; Vallejos, Gerardo; López, Mercedes N.; Salazar Onfray, Flavio; Aguilar Guzmán, Lorena Andrea; Valck Calderón, Carolina Eliana; Ferreira, Arturo; Becker, María Inés (Frontiers Research Foundation, 2017)
      © 2017 Pizarro-Bauerle, Maldonado, Sosoniuk-Roche, Vallejos, López, Salazar-Onfray, Aguilar-Guzmán, Valck, Ferreira and Becker. Molluskan hemocyanins are enormous oxygen-carrier glycoproteins that show remarkable ...
    • Prolonged survival of dendritic cell-vaccinated melanoma patients correlates with tumor-specific delayed type IV hypersensitivity response and reduction of tumor growth factor β-expressing T cells 

      López, Mercedes N.; Pereda, Cristian; Segal, Gabriela; Muñoz, Leonel; Aguilera, Raquel; González, Fermín E.; Escobar, Alejandro; Ginesta, Alexandra; Reyes, Diego; González, Rodrigo; Mendoza Naranjo, Ariadna; Larrondo, Milton; Compán, Alvaro; Ferrada, Carlos; Salazar-On (2009)
      Purpose The aim of this work was to assess immunologic response, disease progression, and posttreatment survival of melanoma patients vaccinated with autologous dendritic cells (DCs) pulsed with a novel allogeneic cell ...
    • Proteomic identification of heat shock induced danger signals in a melanoma cell lysate used in dendritic cell based cancer immunotherapy 

      González, Fermin E.; Chernobrovkin, Alexey; Pereda, Cristián; García Salum, Tamara; López, Mercedes N.; Salazar Onfray, Flavio; Zubarev, Roman A.; Tittarelli, Andrés (Hindawi Ltda., 2018)
      Autologous dendritic cells (DCs) loaded with cancer cell-derived lysates have become a promising tool in cancer immunotherapy. During the last decade, we demonstrated that vaccination of advanced melanoma patients with ...
    • Proteomic identification of heat shock-induced danger signals in a melanoma cell lysate used in dendritic cell-based cancer immunotherapy 

      González, Fermín E.; Chernobrovkin, Alexey; Pereda, Cristián; García-Salum, Tamara; Tittarelli, Andrés; López, Mercedes N.; Salazar Onfray, Flavio; Roman, A. (Hindawi Limited, 2018)
      Copyright © 2018 Fermín E. González et al. Autologous dendritic cells (DCs) loaded with cancer cell-derived lysates have become a promising tool in cancer immunotherapy. During the last decade, we demonstrated that vaccination ...
    • Pure platelet-rich plasma and supernatant of calcium-activated P-PRP induce different phenotypes of human macrophages 

      Escobar, Gisselle; Escobar Álvarez, Alejandro; Ascui, Gabriel; Tempio, Fabián I.; Ortiz, María C.; Pérez Núñez, Claudio; López, Mercedes N. (Future Medicine, 2018)
      Aim: This study aimed to evaluate the effect of two platelet preparations used in the clinic, pure platelet-rich plasma (P-PRP) and the supernatant of calcium-activated P-PRP (S-PRP), on the phenotype of human macrophages. ...
    • Role of dendritic cells in the induction of lymphocyte tolerance 

      Osorio, Fabiola; Fuentes, Camila; López, Mercedes N.; Salazar Onfray, Flavio; González, Fermín E. (Frontiers Media, 2015)
      The ability of dendritic cells (DCs) to trigger tolerance or immunity is dictated by the context in which an antigen is encountered. A large body of evidence indicates that antigen presentation by steady-state DCs induces ...
    • TAPcells, the Chilean dendritic cell vaccine against melanoma and prostate cancer 

      Salazar Onfray, Flavio; Pereda, Cristián; Reyes, Diego; López, Mercedes N. (2013)
      Here we summarize 10 years of effort in the development of a biomedical innovation with global projections. This innovation consists of a novel method for the production of therapeutic dendritic-like cells called Tumor ...
    • Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients 

      Tittarelli, Andrés; González, Fermín E.; Pereda, Cristián; Mora, Gabriela; Muñoz, Leonel; Saffie, Carlos; García, Tamara; Díaz, David; Falcón, Cristián; Hermoso, Marcela; López, Mercedes N.; Salazar Onfray, Flavio (2012)
      Toll-like receptor 4 (TLR4) is expressed on dendritic cells (DCs), sensing environmental danger molecules that induce their activation and maturation. Recently, we reported a method for the production of therapeutic DCs ...
    • Tumor cell lysates as immunogenic sources for cancer vaccine design 

      González, Fermín E.; Gleisner, Alejandra; Falcón-Beas, Felipe; Osorio, Fabiola; López, Mercedes N.; Salazar Onfray, Flavio (Landes Bioscience, 2014)
      © 2014 Taylor & Francis Group, LLC Autologous dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) are a promising immunological tool for cancer therapy. These stimulate the antitumor response and immunological ...
    • Tumor cell lysates as immunogenic sources for cancer vaccine design 

      González, Fermín E.; Gleisner Muñoz, María Alejandra; Falcón-Beas, Felipe; Osorio, Fabiola; López, Mercedes N.; Salazar Onfray, Flavio (Landes Bioscience, 2014)
      © 2014 Taylor & Francis Group, LLC Autologous dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) are a promising immunological tool for cancer therapy. These stimulate the antitumor response and immunological ...