Now showing items 1-13 of 13

    • Anthraquinone Derivative Reduces Tau Oligomer Progression by Inhibiting Cysteine-Cysteine Interaction 

      Areche, Carlos; Zapata, Francisca; González, Mathias; Díaz, Esteban; Montecinos, Rubén; Hernández, Marcos; Melo, Francisco; Cornejo, Alberto (Wiley-VCH Verlag, 2019)
      Tau protein is a natively unfolded protein whose primary role is to participate in axonal transport closely associated with microtubules. Neurodegenerative disorders including Alzheimer's disease and Tauopathies involved ...
    • Assessment of the Nature Interactions of beta-Amyloid Protein by a Nanoprobe Method 

      Caballero, Leonardo; Mena, Juan; Morales Alvarez, Aurora; Kogan Bocian, Marcelo; Melo, Francisco (Amer Chemical Soc, 2015)
      We present a method based on atomic force microscopy (AFM) to assess the work of adhesion between the interfaces of gold AFM tips functionalized with three peptides derived from beta-sheet breaker LPFFD [CLPFFD-NH2 (i(0)) ...
    • Detecting protein folding by thermal fluctuations of microcantilevers 

      Muñoz, Romina; Aguilar-Sandoval, Felipe; Bellon, Ludovic; Melo, Francisco (Public Library of Science, 2017)
      © 2017 Muñoz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
    • Does bacterial elasticity affect adhesion to polymer fibers? 

      Tamayo Villarroel, Laura; Melo, Francisco; Caballero, Leonardo; Hamm, Eugenio; Díaz, M.; Leal, M. S.; Guiliani, Nicolás; Urzúa, M. D. (American Chemical Society, 2020)
      The factors governing bacterial adhesion to substrates with different topographies are still not fully identified. The present work seeks to elucidate for the first time and with quantitative data the roles of bacterial ...
    • Expression of transposable elements in neural tissues during Xenopus development 

      Faunes, Fernando; Sanchez, Natalia; Moreno, Mauricio; Olivares, Gonzalo H.; Lee-Liu, Dasfne; Almonacid, Leonardo; Slater, Alex W.; Norambuena, Tomas; Taft, Ryan J.; Mattick, John S.; Melo, Francisco; Larrain, Juan (2011)
      Transposable elements comprise a large proportion of animal genomes. Transposons can have detrimental effects on genome stability but also offer positive roles for genome evolution and gene expression regulation. Proper ...
    • General solution for shear strength estimate of RC elements based on panel response 

      Massone, Leonardo; Melo, Francisco (Elsevier Ltd, 2018)
      The capacity of structural systems subjected to shear loads commonly distinguished by discontinuities such as point loads or supports, or abrupt changes of cross section, where complex fields of stresses and strains are ...
    • Glycated collagen stimulates differentiation of gingival myofibroblasts 

      Retamal, Ignacio N.; Hernández, Romina; Melo, Francisco; Zapata, Paulina; Martínez Winkler, Jorge; Martínez, Constanza; Smith, Patricio C. (American Academy of Periodontology, 2017)
      Background: Glucose-derived metabolites may alter the structure and biologic properties of important proteins in periodontium, such as collagens. As a consequence, it is possible that collagen-binding cells may change their ...
    • Gold nanoparticle-membrane interactions: Implications in biomedicine 

      Riveros, Ana; Dadlani, Komal; Salas, Edison; Caballero, Leonardo; Melo, Francisco; Kogan Bocian, Marcelo (American Scientific Publishers, 2013)
      There has been an increase in the research towards the use of nanoparticles as a promising tool for nanomedicine, from imagenology, drug and gene delivery, to phototherapy. Little is known regarding the interaction between ...
    • Mechanical properties and electrical surface charges of microfibrillated cellulose/imidazole-modified polyketone composite membranes 

      González Cortes, Pablo; Araya Hermosilla, Rodrigo; Araya Hermosilla, Esteban; Acuña, Daniela; Mautner, Andreas; Caballero, Leonardo; Melo, Francisco; Moreno Villoslada, Ignacio; Picchioni, Francesco; Rolleri, Aldo; Quero, Franck (Elsevier, 2020)
      In the present work, microfibrillated cellulose (MFC) suspensions were produced by high-pressure homogenization and subsequently used to fabricate MFC membranes (C-1) by vacuum filtration followed by hot-pressing. A ...
    • Pulling on super paramagnetic beads with micro cantilevers: single molecule mechanical assay application 

      Muñoz, Romina; Aguilar Sandoval, Felipe; Wilson Moya, Christian; Melo, Francisco (IOP Publishing, 2015)
      This paper demonstrates that it is possible to trap and release a super paramagnetic micro bead by fixing three super paramagnetic micro beads in a triangular array at the sensitive end of a micro cantilever, and by simply ...
    • Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to beta sheet in tau protein linked to Alzheimer’s disease 

      Cornejo, Alberto; Aguilar Sandoval, Felipe; Caballero, Leonardo; Machuca, Luis; Muñoz, Patricio; Caballero, Julio; Perry, George; Ardiles, Alejandro; Areche Medina, Carlos; Melo, Francisco (Taylor & Francis, 2017)
      Alzheimer’s disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts targeting amyloid-b plaques have succeeded to remove plaques but failed in clinical trials to improve ...
    • Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to Alzheimer’s disease 

      Cornejo, Alberto; Aguilar Sandoval, Felipe; Caballero, Leonardo; Machuca, Luis; Jorquera Muñoz, Patricio; Caballero, Julio; Perry, George; Ardiles, Alejandro; Areche, Carlos; Melo, Francisco (Taylor and Francis Ltd, 2017)
      © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Alzheimer’s disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts targeting ...
    • Stress transfer and matrix-cohesive fracture mechanism in microfibrillated cellulose-gelatin nanocomposite films 

      Quero, Franck; Padilla, Cristina; Campos, Vanessa; Luengo, Jorge; Caballero, Leonardo; Melo, Francisco; Li, Qiang; Eichhorn, Stephen J.; Enrione, Javier (Elsevier, 2018-09)
      Microfibrillated cellulose (MFC) obtained from eucalyptus was embedded in gelatin from two sources; namely bovine and salmon gelatin. Raman spectroscopy revealed that stress is transferred more efficiently from bovine ...