Now showing items 1-13 of 13

    • Antinociception induced by atorvastatin in different pain models 

      Garcia, G. G.; Miranda, H. F.; Noriega, V.; Sierralta, F.; Olavarría, L.; Zepeda, R. J.; Prieto, J. C. (2011)
      Atorvastatin is a statin that inhibits the 3-hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase. Several landmark clinical trials have demonstrated the beneficial effects of statin therapy for primary and secondary ...
    • Antinociception, tolerance, and physical dependence comparison between morphine and tramadol 

      Miranda, H. F.; Pinardi, G. (Elsevier Inc., 1998)
      The mechanism of action of tramadol includes the activation of opioid receptors, and the potential ability of the drug to induce tolerance and physical dependence has been evaluated in different animal species and humans. ...
    • Antinociceptive interaction of gabapentin with minocycline in murine diabetic neuropathy 

      Miranda, H. F.; Sierralta, F.; Jorquera, V.; Poblete, P.; Prieto, J. C.; Noriega, V. (Birkhauser Verlag AG, 2017)
      © 2017, Springer International Publishing. Objective: Diabetic neuropathy (DN) is the most common complication of diabetes and pain is one of the main symptoms of diabetic neuropathy, however, currently available drugs are ...
    • Cholinergic transmission in vas deferens 

      Bustos, E.; Miranda, H.; Paeile, C. (1983)
      1. 1. Prazosin, haloperidol, propranolol or timolol had no effect on the electrically evoked muscular twitch. 2. 2. Atropine was able to antagonize competitively acetylcholine (pA2 = 9.29 ± 0.30). 3. 3. The muscular twitch ...
    • Effects of CDP-Choline on acetylcholine-induced relaxation of the perfused carotid vascular beds of the rat 

      Pinardi, G.; Pelissier, T.; Kramer, V.; Paeile, C.; Miranda, H. F. (1994)
      1. The effects of an infusion of cytidine-5′-diphosphocholine (CDP-choline) on the relaxation induced by exogenous acetylcholine (ACh) was studied in the isolated and perfuded external (ECB) and internal (ICB) carotid ...
    • Effects of tramadol and dexketoprofen on analgesia and gastrointestinal transit in mice 

      Miranda, H. F.; Puig, M. M.; Romero, M. A.; Prieto, J. C. (2009)
      The purpose of the present study was to evaluate the nature of the antinociceptive interaction among dexketoprofen (DEX), a mixed inhibitor of the cyclo-oxygenases, and tramadol (TRAM), a weak opioid with monoaminergic ...
    • Interaction between dexibuprofen and dexketoprofen in the orofacial formalin test in mice 

      Miranda, H. F.; Noriega, V.; Sierralta García, Fernando; Prieto Domínguez, Juan (Elsevier, 2011)
      Animal models are used to research the mechanisms of pain and tomimic human pain. The purpose of this study was to determine the degree of interaction between dexketoprofen and dexibuprofen, by isobolographic analysis using ...
    • Interaction of opioids with antidepressant-induced antinociception 

      Sierralta, F.; Miranda, H. F.; Pinardi, G.; Mendez, M. (Springer-Verlag, 1995)
      The antinociceptive activity of antidepressant drugs is poorly understood. In this study, using the acetic acid writhing test in mice, the antinociception produced by clomipramine (CLO), maprotiline (MAP), imipramine (IMI), ...
    • Pharmacological actions of substance P in the rat vas deferens 

      Miranda, H. F.; Silva, W. I.; Wolstenholme, W. W.; Cuevas, N.; Ucros, A.; Bustamante, D.; Fernández, E. H. (1991)
      SP produces two different muscular responses in the isolated vas deferens of the rat. 1) A myotropic, post-synaptic effect that results from stimulation of one subtype of SP receptor, located on the membrane of the smooth ...
    • Synergism between COX-3 inhibitors in two animal models of pain 

      Muñoz, J.; Navarro, C.; Noriega, V.; Pinardi,; Sierralta, F.; Prieto, J. C.; Miranda, H. F. (2010)
      Objective and design: The antinociception induced by the intraperitoneal coadministration in mice of combinations of metamizol and paracetamol was evaluated in the tail flick test and orofacial formalin test. Methods: The ...
    • Synergism between NSAIDs in the orofacial formalin test in mice 

      Miranda, H. F.; Sierralta, F.; Prieto, J. C. (2009)
      Opioids and non-steroidal anti-inflammatory drugs (NSAIDs) are used to relieve acute and chronic pain. The purpose of this study was to determine the degree of interaction between dexketoprofen and NSAID examples of COXs ...
    • Synergy between the antinociceptive effects of morphine and NSAIDs 

      Miranda, H. F.; Silva, E.; Pinardi, (2004)
      The intraperitoneal administration of morphine, diclofenac, ketoprofen, meloxicam, metamizol, paracetamol and piroxicam induced dose-dependent antinociception in mice tested with the acetic acid writhing test. The ...