Now showing items 1-5 of 5

    • Angiotensin (1-7) decreases myostatin-induced NF-kappa B signaling and skeletal muscle atrophy 

      Aravena, Javier; Abrigo, Johanna; González, Francisco; Aguirre, Francisco; González, Andrea; Simon Pino, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)
      Myostatin is a myokine that regulates muscle function and mass, producing muscle atrophy. Myostatin induces the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. The main pathway that mediates ...
    • Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor 

      Abrigo, Johanna; González, Francisco; Aguirre, Francisco; Tacchi, Franco; González, Andrea; Meza, María Paz; Simón, Felipe; Cabrera, Daniel; Arrese, Marco; Karpen, Saúl; Cabello Verrugio, Claudio (Wiley, 2020)
      Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle-specific E3 ligases, atrogin-1 and MuRF-1, and ...
    • Protective effect of Angiotensin 1–7 on Sarcopenia induced by chronic liver disease in mice 

      Aguirre, Francisco; Abrigo, Johanna; Altimiras González, Francisco; González, Andrea; Simon, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)
      Sarcopenia associated with chronic liver disease (CLD) is one of the more common extrahepatic features in patients with these pathologies. Among the cellular alterations observed in the muscle tissue under CLD is the decline ...
    • Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD) 

      González, Andrea; Huerta Salgado, Camila; Orozco Aguilar, Josué; Aguirre, Francisco; Tacchi, Franco; Simón, Felipe; Cabello Verrugio, Claudio (Hindawi, 2020)
      Nonalcoholic fatty liver disease (NAFLD) is a pathology that contains a broad liver dysfunctions spectrum. These alterations span from noninflammatory isolated steatosis until nonalcoholic steatohepatitis (NASH), a more ...
    • Sarcopenia induced by chronic liver disease in mice requires the expression of the bile acids membrane receptor TGR5 

      Abrigo, Johanna; Campos, Fabián; González, Francisco; Aguirre, Francisco; González, Andrea; Huerta Salgado, Camila; Conejeros, Sabrina; Simon, Felipe; Arrese, Marco; Cabrera, Daniel; Elorza, Alvaro A.; Cabello Verrugio, Claudio (MDPI, 2020)
      Sarcopenia is a condition of muscle dysfunction, commonly associated with chronic liver disease (CLD), characterized by a decline in muscle strength, the activation of the ubiquitin-proteasome system (UPS), and oxidative ...