Now showing items 1-3 of 3

    • Conjugation of Kahalalide F with gold nanoparticles to enhance in vitro antitumoral activity 

      Hosta, Leticia; Pla-Roca, Mateu; Arbiol, Jordi; López Iglesias, Carmen; Samitier, Josep; Cruz, Luis; Kogan Bocian, Marcelo; Albericio, Fernando (2009)
      Two Cys-containing analogues of the anticancer drug Kahalalide F are synthesized and conjugated to 20 and 40 nm gold nanoparticles (GNPs). The resulting complexes are characterized by different analytical techniques to ...
    • Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor 

      Prades, Roger; Guerrero, Simón; Araya, Eyleen; Molina, Claudia; Salas, Edison; Zurita, Esther; Selva, Javier; Egea, Gustavo; López-Iglesias, Carmen; Teixidó, Meritxell; Kogan Bocian, Marcelo; Giralt, Ernest (2012)
      The treatment of Alzheimer's disease and many other brain-related disorders is limited because of the presence of the blood-brain barrier, which highly regulate the crossing of drugs. Metal nanoparticles have unique features ...
    • Mechanistic aspects of CPP-mediated intracellular drug delivery: Relevance of CPP self-assembly 

      Pujals, Sílvia; Fernández Carneado, Jimena; López Iglesias, Carmen; Kogan Bocian, Marcelo; Giralt, Ernest (ELSEVIER, 2006-03)
      In recent years, cell-penetrating peptides have proven to be an efficient intracellular delivery system. The mechanism for CPP internalisation, which first involves interaction with the extracellular matrix, is followed ...