Browsing by Author "f08e7167-51d9-4c1c-bf48-b71b13884421"

Now showing items 1-12 of 12

    • Alveolar bone resorption and TH1/TH17-associated immune response triggered during Aggregatibacter ... 
      Monasterio, Gustavo; Castillo, Francisca; Ibarra, Juan; Guevara, José; Rojas, Leticia; Alvarez, Carla; Fernández, Baltasar; Agüero, Amaru; Betancur, Daniel; Vernal Astudillo, Rolando (Wiley-Blackwell, 2018)
      BACKGROUND: Aggregatibacter actinomycetemcomitans expresses several virulence factors that may contribute to the pathogenesis of periodontitis. Based on the antigenicity of the O-polysaccharide component of the ...
    • Alzheimer's Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent 
      Díaz Zúñiga, Jaime; More, Jamileth Y.; Melgar Rodríguez, Samanta; Jiménez Unión, Matías; Villalobos Orchard, Francisca; Muñoz Manríquez, Constanza; Monasterio, Gustavo; Valdés Guerrero, José; Vernal, Rolando; Paula-Lima, Andrea (Frontiers Media, 2020)
      Periodontal disease is a disease of tooth-supporting tissues. It is a chronic disease with inflammatory nature and infectious etiology produced by a dysbiotic subgingival microbiota that colonizes the gingivodental sulcus. ...
    • Capsular-defective Porphyromonas gingivalis mutant strains induce less alveolar bone resorption than W50 ... 
      Monasterio, Gustavo; Fernández, Baltasar; Castillo, Francisca; Rojas, Carolina; Cafferata, Emilio A.; Rojas, Leticia; Alvarez, Carla; Fernández, Alejandra; Hernández, Marcela; Bravo, Denisse; Vernal Astudillo, Rolando (Wiley-Blackwell, 2019)
      Background: Encapsulation of Porphyromonas gingivalis has been demonstrated as responsible of several host immunological changes, which have been associated with the pathogenesis of periodontitis. Using a murine model of ...
    • Differential human Th22-lymphocyte response triggered by Aggregatibacter actinomycetemcomitans serotypes 
      Díaz Zúñiga, Jaime; Melgar Rodríguez, Samanta; Monasterio, Gustavo; Pujol, Myriam; Rojas, Leticia; Alvarez, Carla; Carvajal, Paola; Vernal Astudillo, Rolando (Elsevier Ltd, 2017)
      Objective: In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on lipopolysaccharide (LPS) antigenicity. When T lymphocytes were stimulated with these serotypes, different patterns of ...
    • IL-22–expressing CD4 + AhR + T lymphocytes are associated with RANKL-mediated alveolar bone resorption ... 
      Monasterio, Gustavo; Budini, Victoria; Fernández, Baltasar; Castillo, Francisca; Rojas, Carolina; Alvarez, Carla; Cafferata, Emilio A.; Vicencio, Emiliano; Cortés, Bastián I.; Cortez, Cristian; Vernal Astudillo, Rolando (Blackwell Munksgaard, 2019)
      Background and Objective: Over the past few years, the importance of interleukin-22 (IL-22) and T-helper (Th)22 lymphocytes in the pathogenesis of periodontitis has become apparent; however, there are still aspects that ...
    • Immunostimulatory activity of low-molecular-weight hyaluronan on dendritic cells stimulated with Aggregatibacter ... 
      Monasterio, Gustavo; Guevara, José; Ibarra, Juan; Castillo, Francisca; Díaz Zúñiga, Jaime; Alvarez, Carla; Cafferata, Emilio; Vernal Astudillo, Rolando (Springer Verlag, 2018)
      Objectives Periodontitis is a chronic inflammatory disease characterized by tooth-supporting tissue destruction, which is elicited by the host’s immune response triggered against periodonto-pathogen bacteria. During ...
    • Multifunctional nanocarriers for the treatment of periodontitis: Immunomodulatory, antimicrobial, and ... 
      Cafferata, Emilio A.; Alvarez, Carla; Diaz, Karla T.; Maureira, Miguel; Monasterio, Gustavo; González, Fermín E.; Covarrubias, Cristian; Vernal Astudillo, Rolando (Blackwell Publishing Ltd, 2019)
      © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved Periodontitis is an inflammatory disease, in which the host immuno-inflammatory response against the dysbiotic subgingival biofilm leads ...
    • O-polysaccharide plays a major role on the virulence and immunostimulatory potential of aggregatibacter ... 
      Monasterio, Gustavo; Ormeño Castillo, Francisca; Astorga, Jéssica; Hoare Teuche, Anilei; Terraza, Claudia; Cafferata, Emilio A.; Villablanca, Eduardo J.; Vernal Astudillo, Rolando Marcelo (Frontiers Media, 2020)
      Aggregatibacter actinomycetemcomitans is a Gram-negative oral bacterium with high immunostimulatory and pathogenic potential involved in the onset and progression of periodontitis, a chronic disease characterized by aberrant ...
    • Regulatory T cell phenotype and anti osteoclastogenic function in experimental periodontitis 
      Álvarez, Carla; Suliman, Salwa; Almarhoumi, Rawan; Vega, María Elena; Rojas, Carolina; Monasterio, Gustavo; Galindo, Mario; Vernal Astudillo, Rolando; Kantarci, Alpdogan (Nature, 2020)
      The alveolar bone resorption is a distinctive feature of periodontitis progression and determinant for tooth loss. Regulatory T lymphocytes (Tregs) display immuno-suppressive mechanisms and tissue repairing functions, which ...
    • Regulatory T lymphocytes in periodontitis: A translational view 
      Alvarez, Carla; Rojas Rojas, Carolina Andrea; Rojas, Leticia; Cafferata, Emilio A.; Monasterio, Gustavo; Vernal Astudillo, Rolando (Hindawi Ltd, 2018)
      Periodontitis is a chronic immuno-inflammatory disease in which the disruption of the balance between host and microbiota interactions is key to the onset and progression of the disease. The immune homeostasis associated ...
    • Serotype a of Aggregatibacter actinomycetemcomitans down-regulates the increased serotype b-induced cytokine ... 
      Rojas, Leticia; Melgar Rodríguez, Samanta; Díaz Zúñiga, Jaime; Alvarez, Carla; Monasterio, Gustavo; Rojas, Carolina; Carvajal, Paola; Vernal Astudillo, Rolando (Elsevier Ltd, 2018)
      Objective: In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on LPS antigenicity. Mixed infection with the different A. actinomycetemcomitans serotypes is frequent in periodontitis ...
    • The therapeutic potential of regulatory T lymphocytes in periodontitis: A systematic review 
      Cafferata, Emilio Alfredo; Jerez, Alfredo; Vernal Astudillo, Rolando; Monasterio, Gustavo; Pandis, Nikolaos; Faggion, Clovis M. (Blackwell, 2019)
      This systematic review aimed to: (a) generate a descriptive synthesis of preclinical studies assessing the therapeutic potential of regulatory T lymphocytes (Tregs) to arrest periodontitis, (b) evaluate the methodological ...